TBX18 overexpression enhances pacemaker function in a rat subsidiary atrial pacemaker model of sick sinus syndrome

scientific article published on 13 October 2018

TBX18 overexpression enhances pacemaker function in a rat subsidiary atrial pacemaker model of sick sinus syndrome is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1113/JP276508
P932PMC publication ID6292813
P698PubMed publication ID30259525

P50authorGwilym M. MorrisQ40410997
Halina DobrzynskiQ44620952
Alicia D'SouzaQ63977591
Moinuddin ChoudhuryQ91797410
P2093author name stringH Zhang
R Wang
N Black
A Alghamdi
M R Boyett
P A Kingston
J Yanni
P2860cites workFamilial sinus bradycardia associated with a mutation in the cardiac pacemaker channelQ24300840
Pacemaker channel dysfunction in a patient with sinus node diseaseQ24301951
Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cellsQ28218949
Transcription factor Tbx3 is required for the specification of the atrioventricular conduction systemQ28512690
Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3Q28594589
Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4Q30498016
Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18.Q30544927
High incidence of pacemaker syndrome in patients with sinus node dysfunction treated with ventricular-based pacing in the Mode Selection Trial (MOST).Q33151443
2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: the Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm AssociQ33162947
Structural remodelling of the sinoatrial node in obese old ratsQ33754290
The sinoatrial node, a heterogeneous pacemaker structureQ34023812
Incidence of and risk factors for sick sinus syndrome in the general populationQ34069739
Mechanisms of sinoatrial node dysfunction in a canine model of pacing-induced atrial fibrillationQ34079072
A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews.Q34128155
cAMP Sensitivity of HCN Pacemaker Channels Determines Basal Heart Rate But Is Not Critical for Autonomic Rate ControlQ34130292
The anatomy and physiology of the sinoatrial node--a contemporary reviewQ34143598
The 11th world survey of cardiac pacing and implantable cardioverter-defibrillators: calendar year 2009--a World Society of Arrhythmia's projectQ34195611
Biological pacemaker implanted in canine left bundle branch provides ventricular escape rhythms that have physiologically acceptable ratesQ34291219
Cardiac HCN channels: structure, function, and modulationQ34772597
Abnormal response of superior sinoatrial node to sympathetic stimulation is a characteristic finding in patients with atrial fibrillation and symptomatic bradycardia.Q35638679
HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in miceQ36116647
Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMPQ36137322
HCN-encoded pacemaker channels: from physiology and biophysics to bioengineeringQ36844782
Biological pacemaker created by minimally invasive somatic reprogramming in pigs with complete heart block.Q37105417
The road to biological pacingQ37918327
Fibrosis, electrics and genetics. Perspectives in sinoatrial node diseaseQ38212507
A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases.Q38681682
Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2Q39696685
Wild-type and mutant HCN channels in a tandem biological-electronic cardiac pacemaker.Q40241198
The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart.Q40553027
HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with I(f) blockadeQ41875995
Mechanisms of automaticity in subsidiary pacemakers from cat right atriumQ43444149
Expression and function of a biological pacemaker in canine heartQ44342373
Characterization of a right atrial subsidiary pacemaker and acceleration of the pacing rate by HCN over-expressionQ45888497
Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome modelQ46213607
Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signatureQ46255546
Molecular architecture of the human sinus node: insights into the function of the cardiac pacemakerQ46535702
Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunctionQ47866464
Upregulation of the hyperpolarization-activated current increases pacemaker activity of the sinoatrial node and heart rate during pregnancy in mice.Q51050824
Inactivation of the calcium current is involved in overdrive suppression of rabbit sinoatrial node cells.Q51558348
Effect of ryanodine on sinus node recovery time determined in vitro.Q52536092
Sick sinus syndrome in HCN1-deficient mice.Q54620192
Formation of the Venous Pole of the Heart From an Nkx2-5-Negative Precursor Population Requires Tbx18Q56000972
High-Density Mapping of the Sinus Node in Humans: Role of Preferential Pathways and the Effect of RemodelingQ58865303
Demonstration of a widely distributed atrial pacemaker complex in the human heartQ68362222
Electrophysiology and ultrastructure of eustachian ridge from cat right atrium: a comparison with SA nodeQ68674131
The role of calcium in overdrive suppression of canine cardiac Purkinje fibersQ70396647
Alterations in subsidiary pacemaker function after prolonged subsidiary pacemaker dominance in the canine right atriumQ70591462
Changes in the electrical activity of dog cardiac Purkinje fibres at high heart ratesQ72386512
Electrophysiological and electroanatomic characterization of the atria in sinus node disease: evidence of diffuse atrial remodelingQ79749000
Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillationQ85521607
P433issue24
P921main subjectsick sinus syndromeQ1757915
P304page(s)6141-6155
P577publication date2018-10-13
P1433published inJournal of PhysiologyQ7743612
P1476titleTBX18 overexpression enhances pacemaker function in a rat subsidiary atrial pacemaker model of sick sinus syndrome
P478volume596