Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models

scientific article published on 02 July 2012

Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FPHYS.2012.00240
P932PMC publication ID3387723
P698PubMed publication ID22783204
P5875ResearchGate publication ID229065783

P2093author name stringAndrea Barbuti
Dario Difrancesco
Annalisa Bucchi
Mirko Baruscotti
P2860cites workPacemaker channel dysfunction in a patient with sinus node diseaseQ24301951
Age-related down-regulation of HCN channels in rat sinoatrial nodeQ28579448
The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heartQ28585488
The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotidesQ28586569
Expression of the hyperpolarization-activated cyclic nucleotide-gated cation channel HCN4 during mouse heart developmentQ28591825
Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3Q28594589
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouseQ29620355
Behavioral profiles of three C57BL/6 substrainsQ30480322
Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4Q30498016
Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial nodeQ30672430
Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissuesQ33867597
The sinoatrial node, a heterogeneous pacemaker structureQ34023812
The role of the funny current in pacemaker activity.Q34099619
Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain.Q34178989
Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heartQ34361080
Functional expression of the human HCN3 channelQ34436879
All (C57BL/6) Mice are not Created EqualQ34613138
Pacemaker current (I(f)) in the human sinoatrial node.Q34682132
Hyperpolarization-activated cation channels: from genes to functionQ34991085
Functional roles of Ca(v)1.3, Ca(v)3.1 and HCN channels in automaticity of mouse atrioventricular cells: insights into the atrioventricular pacemaker mechanismQ35577771
Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.Q35859013
What keeps us ticking: a funny current, a calcium clock, or both?Q36010630
Use-dependent inhibition of hHCN4 by ivabradine and relationship with reduction in pacemaker activityQ36052500
HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in miceQ36116647
Physiology and pharmacology of the cardiac pacemaker ("funny") currentQ36166537
Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP.Q36487302
The pacemaker current: from basics to the clinics.Q36729727
Behavioral differences among C57BL/6 substrains: implications for transgenic and knockout studies.Q36971705
Genesis and regulation of the heart automaticity.Q37216067
Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5.Q37222054
Control of heart rate by cAMP sensitivity of HCN channelsQ37274509
The cardiac pacemaker currentQ37547401
Development of the pacemaker tissues of the heart.Q37687712
HCN-related channelopathies.Q37705120
Rebuttal: "The funny current in the context of the coupled clock pacemaker cell system".Q38549664
The funny current has a major pacemaking role in the sinus nodeQ38549668
Funny current channel HCN4 delineates the developing cardiac conduction system in chicken heartQ38550067
Molecular basis of funny current (If) in normal and failing human heart.Q38551800
Single cells isolated from human sinoatrial node: action potentials and numerical reconstruction of pacemaker current.Q38552243
Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2Q39696685
Tamoxifen-inducible gene deletion in the cardiac conduction systemQ42437141
HCN3 contributes to the ventricular action potential waveform in the murine heartQ42494063
Beta1-adrenergic receptors maintain fetal heart rate and survivalQ43505292
Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissuesQ43542437
I(f) current and spontaneous activity in mouse embryonic ventricular myocytesQ43542922
Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre proteinQ43664631
Catecholamines act via a beta-adrenergic receptor to maintain fetal heart rate and survivalQ44306623
Site of origin and molecular substrate of atrioventricular junctional rhythm in the rabbit heartQ44620905
Development of pacemaker tissue in the embryonic heartQ44760857
Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy.Q46015905
Distribution of the pacemaker HCN4 channel mRNA and protein in the rabbit sinoatrial node.Q46036929
Molecular architecture of the human sinus node: insights into the function of the cardiac pacemakerQ46535702
The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar Purkinje cellsQ48128133
Whole brain methionine-enkephalin of ethanol-avoiding and ethanol-preferring c57BL miceQ48859602
Insights into sick sinus syndrome from an inducible mouse model.Q50529786
Properties of the hyperpolarizing-activated current (if) in cells isolated from the rabbit sino-atrial nodeQ57980198
Organisation of the mouse sinoatrial node: structure and expression of HCN channelsQ59594730
Differential Expression of Ion Channel Transcripts in Atrial Muscle and Sinoatrial Node in RabbitQ59594734
Extended atrial conduction system characterised by the expression of the HCN4 channel and connexin45Q59594754
Location of pacemaker in chick embryo heart at the time of initiation of heartbeatQ72203787
Comparison of ion-channel subunit expression in canine cardiac Purkinje fibers and ventricular muscleQ78460665
Modulation of rate by autonomic agonists in SAN cells involves changes in diastolic depolarization and the pacemaker currentQ80417832
Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure modelQ81781351
Not so fast! Sick sinus syndrome is a complex and incompletely understood disease that might prove hard to model in animalsQ84596244
Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heartQ84980492
P304page(s)240
P577publication date2012-07-02
P1433published inFrontiers in PhysiologyQ2434141
P1476titleFunny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models
P478volume3