Baf250a orchestrates an epigenetic pathway to repress the Nkx2.5-directed contractile cardiomyocyte program in the sinoatrial node

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Baf250a orchestrates an epigenetic pathway to repress the Nkx2.5-directed contractile cardiomyocyte program in the sinoatrial node is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/CR.2014.113
P932PMC publication ID4185344
P698PubMed publication ID25145359
P5875ResearchGate publication ID263928925

P50authorJialiang YangQ56454623
P2093author name stringMeng Wu
Yong Zhao
Zhong Wang
Chen-Leng Cai
Zhidong Tu
Xiaoqiang Cai
Siwu Peng
P2860cites workBiphasic development of the mammalian ventricular conduction system.Q50553455
T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.Q51803470
Chromatin remodeling in heart development.Q51902171
Ageing-related changes of connexins and conduction within the sinoatrial node.Q52858881
Formation of the ventricles.Q55416364
Several common variants modulate heart rate, PR interval and QRS durationQ57309310
Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channelQ24300840
Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node diseaseQ24318595
The DNA-binding properties of the ARID-containing subunits of yeast and mammalian SWI/SNF complexesQ24613851
Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atriaQ24681355
An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferationQ27863351
The cardiac conduction systemQ28116242
Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A)Q28206505
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genesQ28255974
Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking developmentQ28506813
ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250aQ28508327
Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septationQ28509085
Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasisQ28586231
A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and diseaseQ28594121
Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3Q28594589
Genomic maps and comparative analysis of histone modifications in human and mouseQ29614418
Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoterQ29616537
The biology of chromatin remodeling complexesQ29620581
Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18.Q30544927
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A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.Q33722486
Genome-wide association study of PR intervalQ33772170
The sinoatrial node, a heterogeneous pacemaker structureQ34023812
The role of the funny current in pacemaker activity.Q34099619
Biological pacemaker created by gene transferQ34149202
The inward rectifier current (IK1) controls cardiac excitability and is involved in arrhythmogenesisQ34413683
Control of cardiac growth by histone acetylation/deacetylationQ34482206
Making or breaking the heart: from lineage determination to morphogenesisQ34567781
New insights into pacemaker activity: promoting understanding of sick sinus syndromeQ34617500
Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart.Q34805195
Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tractQ35576426
SWI/SNF protein component BAF250a regulates cardiac progenitor cell differentiation by modulating chromatin accessibility during second heart field developmentQ36097940
Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium.Q36389611
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disordersQ36968428
Genesis and regulation of the heart automaticity.Q37216067
Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5.Q37222054
The cardiac pacemaker and conduction system develops from embryonic myocardium that retains its primitive phenotype.Q37761020
Epigenetics and cardiovascular development.Q37950482
Transcription factor pathways and congenital heart disease.Q37997218
Bradyarrhythmias in the elderlyQ38055784
Regulation of CSF1 promoter by the SWI/SNF-like BAF complexQ38297752
A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac developmentQ38458441
System for tamoxifen-inducible expression of cre-recombinase from the Foxa2 locus in miceQ38502825
A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cellsQ39483876
Inducible gene deletion in the entire cardiac conduction system using Hcn4-CreERT2 BAC transgenic miceQ41928156
Local control of Ca2+-induced Ca2+ release in mouse sinoatrial node cells.Q42583209
The myogenic basic helix-loop-helix family of transcription factors shows similar requirements for SWI/SNF chromatin remodeling enzymes during muscle differentiation in cultureQ42812943
Maintenance of cardiac energy metabolism by histone deacetylase 3 in miceQ43012174
P275copyright licenseCreative Commons Attribution-NonCommercial-ShareAlike 3.0 UnportedQ15643954
P6216copyright statuscopyrightedQ50423863
P433issue10
P304page(s)1201-1213
P577publication date2014-08-22
P1433published inCell ResearchQ1524018
P1476titleBaf250a orchestrates an epigenetic pathway to repress the Nkx2.5-directed contractile cardiomyocyte program in the sinoatrial node
P478volume24

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cites work (P2860)
Q35878118A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node
Q38929418ATP-dependent chromatin remodeling during mammalian development.
Q48823094BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility
Q45262771Development and Function of the Cardiac Conduction System in Health and Disease
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Q36036349Gene-Specific Assessment of Guanine Oxidation as an Epigenetic Modulator for Cardiac Specification of Mouse Embryonic Stem Cells
Q36372470Genetic Regulation of Sinoatrial Node Development and Pacemaker Program in the Venous Pole
Q47932384MicroRNA expression, target genes, and signaling pathways in infants with a ventricular septal defect
Q91374435Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome
Q89623325SWI/SNF Component BAF250a Coordinates OCT4 and WNT Signaling Pathway to Control Cardiac Lineage Differentiation
Q42379230Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells.
Q39998931Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration
Q42705132Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia.
Q26770904The formation and function of the cardiac conduction system
Q89014504Transcriptional regulation of the cardiac conduction system
Q38695345Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice
Q58603355smarce1 mutants have a defective endocardium and an increased expression of cardiac transcription factors in zebrafish

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