Genetic Regulation of Sinoatrial Node Development and Pacemaker Program in the Venous Pole

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Genetic Regulation of Sinoatrial Node Development and Pacemaker Program in the Venous Pole is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/JCDD2040282
P932PMC publication ID4679406
P698PubMed publication ID26682210
P5875ResearchGate publication ID285363797

P2093author name stringYanding Zhang
Zhen Huang
Yiping Chen
Wenduo Ye
Yingnan Song
P2860cites workThe Form and Nature of the Muscular Connections between the Primary Divisions of the Vertebrate HeartQ24534713
Discovery of the sinus node by Keith and Flack: on the centennial of their 1907 publicationQ24564768
VISTA Enhancer Browser--a database of tissue-specific human enhancersQ24676452
Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atriaQ24681355
Identification and functional characterization of cardiac pacemaker cells in zebrafishQ27313717
An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferationQ27863351
The role of Pitx2 during cardiac development. Linking left-right signaling and congenital heart diseasesQ28202677
Localization of Islet-1-positive cells in the healthy and infarcted adult murine heartQ28262163
Molecular pathway for the localized formation of the sinoatrial nodeQ28284039
Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking developmentQ28506813
Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septationQ28509085
Transcription factor Tbx3 is required for the specification of the atrioventricular conduction systemQ28512690
Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasisQ28586231
Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardiumQ28586689
Cloning and expression pattern of chicken Pitx2: a new component in the SHH signaling pathway controlling embryonic heart loopingQ47939390
Tbx18 and the fate of epicardial progenitorsQ48000607
Insights into sick sinus syndrome from an inducible mouse model.Q50529786
Developmental origin, growth, and three-dimensional architecture of the atrioventricular conduction axis of the mouse heart.Q51903075
Nkx2.5-negative myocardium of the posterior heart field and its correlation with podoplanin expression in cells from the developing cardiac pacemaking and conduction system.Q51988770
Pitx2 expression defines a left cardiac lineage of cells: evidence for atrial and ventricular molecular isomerism in the iv/iv mice.Q52140742
Formation of the Venous Pole of the Heart From an Nkx2-5-Negative Precursor Population Requires Tbx18Q56000972
Development of the pulmonary veinQ83153151
The development of the pulmonary vein revisitedQ83321091
Not so fast! Sick sinus syndrome is a complex and incompletely understood disease that might prove hard to model in animalsQ84596244
Genetics of Sick Sinus SyndromeQ95807399
Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardiumQ28589895
Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3Q28594589
Genetics of sick sinus syndromeQ28741053
Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18.Q30544927
Fine tuning of craniofacial morphology by distant-acting enhancersQ30576356
HCN4 dynamically marks the first heart field and conduction system precursorsQ33598169
Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillationQ33835308
Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome.Q33982881
Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specificationQ34006337
Baf250a orchestrates an epigenetic pathway to repress the Nkx2.5-directed contractile cardiomyocyte program in the sinoatrial nodeQ34289875
New insights into pacemaker activity: promoting understanding of sick sinus syndromeQ34617500
A comparative encyclopedia of DNA elements in the mouse genomeQ34700119
Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart.Q34805195
The short stature homeobox 2 (Shox2)-bone morphogenetic protein (BMP) pathway regulates dorsal mesenchymal protrusion development and its temporary function as a pacemaker during cardiogenesisQ35002797
RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cellsQ35132359
Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates.Q35772142
A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial nodeQ35878118
Transcription factor ISL1 is essential for pacemaker development and function.Q36040426
TBX5 drives Scn5a expression to regulate cardiac conduction system functionQ36068330
SCN5A and sinoatrial node pacemaker function.Q36763211
Visualization and functional characterization of the developing murine cardiac conduction systemQ36778773
Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5.Q37222054
Atrial fibrillation: a developmental point of view.Q37590976
Development of the pacemaker tissues of the heart.Q37687712
A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac developmentQ37730021
The cardiac pacemaker and conduction system develops from embryonic myocardium that retains its primitive phenotype.Q37761020
Normal and abnormal development of pulmonary veins: State of the art and correlation with clinical entitiesQ37776810
Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancerQ38324392
Pitx2 confers left morphological, molecular, and functional identity to the sinus venosus myocardiumQ40412634
The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart.Q40553027
Single-cell ATAC-seq: strength in numbersQ40621656
Development of the cardiac conduction tissue in human embryos using HNK-1 antigen expression: possible relevance for understanding of abnormal atrial automaticityQ40824226
Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heartQ42382110
Multiple transcriptional domains, with distinct left and right components, in the atrial chambers of the developing heartQ42637996
Translational medicine. Improving cardiac rhythm with a biological pacemakerQ43131470
The sinus venosus progenitors separate and diversify from the first and second heart fields early in developmentQ44464144
Nkx2-5 suppresses the proliferation of atrial myocytes and conduction systemQ46051748
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P304page(s)282-298
P577publication date2015-11-30
P1433published inJournal of cardiovascular development and diseaseQ27726300
P1476titleGenetic Regulation of Sinoatrial Node Development and Pacemaker Program in the Venous Pole
P478volume2

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cites work (P2860)
Q59133289A loss-of-function mutation underlying familial atrial fibrillation
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Q36859198Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation
Q89661624Comparative study of hyperpolarization-activated currents in pulmonary vein cardiomyocytes isolated from rat, guinea pig, and rabbit
Q38987999Development of the cardiac pacemaker
Q90461383Differences in Expression of Genes Involved in Bone Development and Morphogenesis in the Walls of Internal Thoracic Artery and Saphenous Vein Conduits May Provide Markers Useful for Evaluation Graft Patency
Q92240317Functional Characterization of Rare Variants in the SHOX2 Gene Identified in Sinus Node Dysfunction and Atrial Fibrillation
Q88651515Interplay between cardiac transcription factors and non-coding RNAs in predisposing to atrial fibrillation

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