A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node

scientific article published on 2 July 2015

A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/DEV.120220
P932PMC publication ID4510860
P698PubMed publication ID26138475
P5875ResearchGate publication ID279728248

P50authorRichard P. HarveyQ24067156
P2093author name stringJun Wang
Chao Liu
Cheng Sun
Yanding Zhang
YiPing Chen
Fen Wang
James F Martin
Diankun Yu
Fading Chen
Laura Schrader
Wenduo Ye
Yingnan Song
P2860cites workCistrome: an integrative platform for transcriptional regulation studiesQ21184018
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiationQ24291385
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Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeletonQ28505826
Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking developmentQ28506813
Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palateQ28506891
The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction systemQ28507264
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Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasisQ28586231
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Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardiumQ28589895
Shox2-deficiency leads to dysplasia and ankylosis of the temporomandibular joint in miceQ28592303
Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3Q28594589
Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veinsQ29620720
HCN4 dynamically marks the first heart field and conduction system precursorsQ33598169
Extended atrial conduction system characterised by the expression of the HCN4 channel and connexin45Q59594754
Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touchQ60694979
Cardiac and smooth muscle cell contribution to the formation of the murine pulmonary veinsQ73949418
Automaticity in the coronary sinusQ77906553
Left right asymmetry, the pulmonary vein, and a-fibQ81514924
Topographic analysis of the coronary sinus and major cardiac veins by computed tomographyQ81916887
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The development of the pulmonary vein revisitedQ83321091
Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillationQ33835308
Development of the pulmonary vein and the systemic venous sinus: an interactive 3D overviewQ33968240
Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specificationQ34006337
Baf250a orchestrates an epigenetic pathway to repress the Nkx2.5-directed contractile cardiomyocyte program in the sinoatrial nodeQ34289875
Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3Q34341676
An atypical canonical bone morphogenetic protein (BMP) signaling pathway regulates Msh homeobox 1 (Msx1) expression during odontogenesisQ34467651
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Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium.Q36389611
Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterningQ36433714
The heart-forming fields: one or multiple?Q36854392
Prevalence and spectrum of Nkx2.5 mutations associated with idiopathic atrial fibrillationQ36906864
Nkx2-5 mediates differential cardiac differentiation through interaction with Hoxa10.Q37025687
Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitorQ37135357
Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5.Q37222054
Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggersQ37403084
The anatomy of the coronary sinus venous system for the cardiac electrophysiologistQ37622589
Development of the pacemaker tissues of the heart.Q37687712
A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac developmentQ37730021
Normal and abnormal development of pulmonary veins: State of the art and correlation with clinical entitiesQ37776810
Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancerQ38324392
Pitx2 confers left morphological, molecular, and functional identity to the sinus venosus myocardiumQ40412634
Islet1 is a direct transcriptional target of the homeodomain transcription factor Shox2 and rescues the Shox2-mediated bradycardiaQ41136701
Generation of Shox2-Cre allele for tissue specific manipulation of genes in the developing heart, palate, and limbQ41773233
Locomotor rhythm generation linked to the output of spinal shox2 excitatory interneuronsQ42253746
Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heartQ42382110
A novel PITX2c loss-of-function mutation associated with familial atrial fibrillationQ44880531
A novel NKX2.5 loss-of-function mutation responsible for familial atrial fibrillationQ45022910
The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart fieldQ46196456
Comparative transgenic analysis of enhancers from the human SHOX and mouse Shox2 genomic regionsQ47768125
Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndromeQ47955346
Lineage tree for the venous pole of the heart: clonal analysis clarifies controversial genealogy based on genetic tracing.Q50792328
Nkx2.5-negative myocardium of the posterior heart field and its correlation with podoplanin expression in cells from the developing cardiac pacemaking and conduction system.Q51988770
Embryonic conduction tissue: a spatial correlation with adult arrhythmogenic areas.Q52001186
Embryonic expression of an Nkx2-5/Cre gene using ROSA26 reporter mice.Q52125445
HNK-1 expression patterns in the embryonic rat heart distinguish between sinuatrial tissues and atrial myocardium.Q52172317
Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5.Q53963814
Formation of the Venous Pole of the Heart From an Nkx2-5-Negative Precursor Population Requires Tbx18Q56000972
Organisation of the mouse sinoatrial node: structure and expression of HCN channelsQ59594730
P433issue14
P407language of work or nameEnglishQ1860
P1104number of pages12
P304page(s)2521-2532
P577publication date2015-07-02
P1433published inDevelopmentQ3025404
P1476titleA common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node
P478volume142

Reverse relations

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