Transcription factor TBX18 promotes adult rat bone mesenchymal stem cell differentiation to biological pacemaker cells

scientific article published on 16 November 2017

Transcription factor TBX18 promotes adult rat bone mesenchymal stem cell differentiation to biological pacemaker cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3892/IJMM.2017.3259
P932PMC publication ID5752232
P698PubMed publication ID29207072

P2093author name stringMei Yang
Yanjun Li
Le Li
Congxin Huang
Yanhong Tang
Gege Zhang
Bingjie Ye
P2860cites workmHCN4 genetically modified canine mesenchymal stem cells provide biological pacemaking function in complete dogs with atrioventricular blockQ42438283
Differentiation of allogeneic mesenchymal stem cells induces immunogenicity and limits their long-term benefits for myocardial repairQ42794686
Setting the pace: Tbx3 and Tbx18 in cardiac conduction system developmentQ43071287
Human mesenchymal stem cells as a gene delivery system to create cardiac pacemakersQ44779208
Direct in vivo gene transfer into porcine myocardium using replication-deficient adenoviral vectorsQ45866323
Gene therapy and biological pacingQ45868655
Timing of induction of cardiomyocyte differentiation for in vitro cultured mesenchymal stem cells: a perspective for emergenciesQ46113686
Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signatureQ46255546
Mesenchymal stem cells as a gene delivery system to create biological pacemaker cells in vitroQ47315174
Overexpressing NKx2.5 increases the differentiation of human umbilical cord drived mesenchymal stem cells into cardiomyocyte-like cellsQ50231118
Use of rats mesenchymal stem cells modified with mHCN2 gene to create biologic pacemakers.Q50543570
Generation of cardiac pacemaker cells by programming and differentiation.Q50543937
Mesenchymal stem cells transfected with HCN2 genes by LentiV can be modified to be cardiac pacemaker cells.Q51021119
Proteomic profiling of rat bone marrow mesenchymal stem cells induced by 5-azacytidine.Q51104682
In vivo myocardial gene transfer: Optimization, evaluation and direct comparison of gene transfer vectorsQ62011097
Xenografted adult human mesenchymal stem cells provide a platform for sustained biological pacemaker function in canine heartQ80656654
Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathyQ24291970
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Characterization of mesenchymal stem cells from rat bone marrow: ultrastructural properties, differentiation potential and immunophenotypic markersQ28574524
Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3Q28594589
Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18.Q30544927
Differentiation of bone marrow stromal cells into the cardiac phenotype requires intercellular communication with myocytes.Q33208043
Gene transfer by adenovectorsQ33789647
Transcriptional suppression of connexin43 by TBX18 undermines cell-cell electrical coupling in postnatal cardiomyocytesQ34800053
Hyperpolarization-activated cation currents: from molecules to physiological functionQ35019781
Mesenchymal stem cells (MSC) as therapeutic cytoreagents for gene therapy.Q36072501
Biological pacemaker created by minimally invasive somatic reprogramming in pigs with complete heart block.Q37105417
Concise review: mesenchymal stromal cells: potential for cardiovascular repair.Q37206855
Gene- and cell-based bio-artificial pacemaker: what basic and translational lessons have we learned?Q38016715
Pacemaker activity of the human sinoatrial node: effects of HCN4 mutations on the hyperpolarization-activated currentQ38191158
Stem cell-based biological pacemakers from proof of principle to therapy: a reviewQ38212017
microRNA-124 regulates cardiomyocyte differentiation of bone marrow-derived mesenchymal stem cells via targeting STAT3 signalingQ38324467
Pacing the Heart with Genes: Recent Progress in Biological PacingQ38538855
In situ investigation of allografted mouse HCN4 gene-transfected rat bone marrow mesenchymal stromal cells with the use of patch-clamp recording of ventricular slicesQ38548248
Canine bone marrow mesenchymal stromal cells with lentiviral mHCN4 gene transfer create cardiac pacemakersQ38549177
P433issue2
P921main subjectmesenchymal stem cellQ1922379
stem cell differentiationQ14864672
P304page(s)845-851
P577publication date2017-11-16
P1433published inInternational Journal of Molecular MedicineQ6051492
P1476titleTranscription factor TBX18 promotes adult rat bone mesenchymal stem cell differentiation to biological pacemaker cells
P478volume41

Reverse relations

Q91790358Genetically Modified Porcine Mesenchymal Stem Cells by Lentiviral Tbx18 Create a Biological Pacemakercites workP2860