WD60/FAP163 is a dynein intermediate chain required for retrograde intraflagellar transport in cilia

scientific article published on 17 July 2013

WD60/FAP163 is a dynein intermediate chain required for retrograde intraflagellar transport in cilia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E13-05-0266
P932PMC publication ID3756919
P698PubMed publication ID23864713

P2093author name stringStephen M King
Renée M Gilberti
Erik F Y Hom
Ramila S Patel-King
P2860cites workA novel dynein light intermediate chain colocalizes with the retrograde motor for intraflagellar transport at sites of axoneme assembly in chlamydomonas and Mammalian cellsQ24304623
NEK1 mutations cause short-rib polydactyly syndrome type majewskiQ24324062
Ciliary abnormalities due to defects in the retrograde transport protein DYNC2H1 in short-rib polydactyly syndromeQ24644490
DYNC2H1 mutations cause asphyxiating thoracic dystrophy and short rib-polydactyly syndrome, type IIIQ24645415
Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motorsQ24682888
Cytoplasmic dynein heavy chain 1b is required for flagellar assembly in ChlamydomonasQ27876213
The intraflagellar transport machinery of Chlamydomonas reinhardtiiQ27919639
Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neuronsQ27919666
Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human diseaseQ28118826
Intraflagellar transportQ28131775
Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease geneQ28590359
Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagellaQ28593253
A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT)Q28608952
Exome sequencing identifies DYNC2H1 mutations as a common cause of asphyxiating thoracic dystrophy (Jeune syndrome) without major polydactyly, renal or retinal involvementQ28709034
Short-rib polydactyly and Jeune syndromes are caused by mutations in WDR60Q29147553
CiliopathiesQ29614821
Proteomic analysis of a eukaryotic ciliumQ29614823
Identification of a novel region of the cytoplasmic Dynein intermediate chain important for dimerization in the absence of the light chainsQ30439406
An Outer Arm Dynein Conformational Switch Is Required for Metachronal Synchrony of Motile Cilia in PlanariaQ30497172
Role of a class DHC1b dynein in retrograde transport of IFT motors and IFT raft particles along cilia, but not dendrites, in chemosensory neurons of living Caenorhabditis elegansQ30805155
Identification of oda6 as a Chlamydomonas dynein mutant by rescue with the wild-type geneQ33245378
The retrograde IFT machinery of C. elegans cilia: two IFT dynein complexes?Q33939646
A "holistic" kinesin phylogeny reveals new kinesin families and predicts protein functions.Q34483464
Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians.Q34582287
IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophyQ34624079
A unified taxonomy for ciliary dyneinsQ35567544
The DHC1b (DHC2) isoform of cytoplasmic dynein is required for flagellar assemblyQ36255765
Protein-protein interactions in the 18S ATPase of Chlamydomonas outer dynein armsQ36419553
Characterization of monoclonal antibodies against Chlamydomonas flagellar dyneins by high-resolution protein blottingQ37540899
Asphyxiating thoracic dysplasia: clinical and molecular review of 39 familiesQ38075867
Chlamydomonas FAP133 is a dynein intermediate chain associated with the retrograde intraflagellar transport motorQ42519360
The intermediate chain of cytoplasmic dynein is partially disordered and gains structure upon binding to light-chain LC8.Q45174881
Analysis of xbx genes in C. elegansQ47069052
Light chain 1 from the Chlamydomonas outer dynein arm is a leucine-rich repeat protein associated with the motor domain of the gamma heavy chainQ47959169
The M(r) = 8,000 and 11,000 outer arm dynein light chains from Chlamydomonas flagella have cytoplasmic homologuesQ48073726
Schmidtea mediterranea: a model system for analysis of motile cilia.Q55052845
The Mr 78,000 intermediate chain of Chlamydomonas outer arm dynein interacts with alpha-tubulin in situQ67898936
Structure of the dynein-1 outer arm in sea urchin sperm flagella. I. Analysis by separation of subunitsQ70560670
Large-scale isolation of Chlamydomonas flagellaQ71522109
P4510describes a project that usesImageJQ1659584
P433issue17
P304page(s)2668-2677
P577publication date2013-07-17
P1433published inMolecular Biology of the CellQ2338259
P1476titleWD60/FAP163 is a dynein intermediate chain required for retrograde intraflagellar transport in cilia
P478volume24

Reverse relations

cites work (P2860)
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Q29144881Mutations in the gene encoding IFT dynein complex component WDR34 cause Jeune asphyxiating thoracic dystrophy
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Q30586569The intraflagellar transport dynein complex of trypanosomes is made of a heterodimer of dynein heavy chains and of light and intermediate chains of distinct functions
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Q41709001Whole exome sequencing is an efficient, sensitive and specific method for determining the genetic cause of short-rib thoracic dystrophies