Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease

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Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...752166H
P356DOI10.1371/JOURNAL.PONE.0052166
P3181OpenCitations bibliographic resource ID448284
P932PMC publication ID3534086
P698PubMed publication ID23300604
P5875ResearchGate publication ID234090203

P50authorTim StearnsQ27734166
P2093author name stringTimothy R Stowe
Ramona A Hoh
Erin Turk
P2860cites workGli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and functionQ21145277
The Chlamydomonas genome reveals the evolution of key animal and plant functionsQ22065869
The Ciliopathies: An Emerging Class of Human Genetic DisordersQ22337032
Targeting expression of a transgene to the airway surface epithelium using a ciliated cell-specific promoterQ43671300
Microtubule nucleation by gamma-tubulin-containing rings in the centrosomeQ46052298
Functional genomics in Trypanosoma brucei identifies evolutionarily conserved components of motile flagella.Q46151100
Analysis of xbx genes in C. elegansQ47069052
Characterization of the Drosophila myeloid leukemia factor.Q47070838
Flagellar motility is required for the viability of the bloodstream trypanosomeQ47219440
Regulated targeting of a protein kinase into an intact flagellum. An aurora/Ipl1p-like protein kinase translocates from the cell body into the flagella during gamete activation in chlamydomonasQ47861207
Intraflagellar transport particles participate directly in cilium-generated signaling in ChlamydomonasQ48089194
Insulin receptor-like proteins in Tetrahymena thermophila ciliary membranesQ48263276
Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder.Q51841577
Growth and differentiation of mouse tracheal epithelial cells: selection of a proliferative population.Q52547922
DSAS-6 organizes a tube-like centriole precursor, and its absence suggests modularity in centriole assembly.Q52682166
Transcriptional profiling of mucociliary differentiation in human airway epithelial cells.Q53573827
Identification of novel dyslexia candidate genes through the analysis of a chromosomal deletionQ57317077
Elevated MLF1 expression correlates with malignant progression from myelodysplastic syndromeQ73048175
An improved method for Dictyostelium centrosome isolationQ80223603
Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplicationQ24290438
The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesionQ24290514
The Polo kinase Plk4 functions in centriole duplicationQ24292705
The centriolar satellite protein Cep131 is important for genome stabilityQ24293336
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methodsQ24296940
Asterless is a scaffold for the onset of centriole assemblyQ24300230
Proteomic characterization of the human centrosome by protein correlation profilingQ24301045
Toward a confocal subcellular atlas of the human proteomeQ24301129
Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesionQ24301594
DYX1C1 functions in neuronal migration in developing neocortexQ24304124
Roles of BRCA1 in centrosome duplicationQ24306201
Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosomeQ24306268
Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neuronsQ24307517
HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrityQ24308769
The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cellsQ24316058
Motile cilia of human airway epithelia are chemosensoryQ24317210
Loss of Bardet-Biedl syndrome proteins alters the morphology and function of motile cilia in airway epitheliaQ24317556
Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactinQ24324649
Plk4-induced centriole biogenesis in human cellsQ24336451
The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progressionQ24337908
Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formationQ24338704
SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cellsQ24338767
BioGRID: a general repository for interaction datasetsQ24538650
The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centriolesQ24556578
Centriole evolutionQ24631122
Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesisQ24633064
Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformationQ24642177
Developmental disruptions and behavioral impairments in rats following in utero RNAi of Dyx1c1.Q24671718
A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brainQ24673084
Cyclin-dependent kinase control of centrosome duplicationQ24673544
Centriolar satellites: molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesisQ24680892
Radial spoke proteins of Chlamydomonas flagellaQ24685097
Sensory reception is an attribute of both primary cilia and motile ciliaQ27687126
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
The nonmotile ciliopathiesQ27967648
Functional genomics of the cilium, a sensory organelleQ28118687
The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migrationQ28306226
Age-related retinal degeneration (arrd2) in a novel mouse model due to a nonsense mutation in the Mdm1 geneQ28506396
The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesisQ28585043
Tissue expression patterns identify mouse cilia genesQ28585969
Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease geneQ28590359
The primary cilium: a signalling centre during vertebrate developmentQ29547197
Proteomic analysis of a eukaryotic ciliumQ29614823
Nucleation of microtubule assembly by a gamma-tubulin-containing ring complexQ29615059
Centrioles, centrosomes, and cilia in health and diseaseQ29615173
The primary cilium as a complex signaling centerQ29615254
The ciliary proteome database: an integrated community resource for the genetic and functional dissection of ciliaQ29615741
Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesisQ29618534
The proteome of the mouse photoreceptor sensory cilium complexQ29619586
Calcium influx regulates antibody-induced glycoprotein movements within the Chlamydomonas flagellar membraneQ30456724
Progress towards a cellular neurobiology of reading disabilityQ30475697
Identification of ciliary and ciliopathy genes in Caenorhabditis elegans through comparative genomicsQ30478961
TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cellsQ30483343
Dilatory is a Drosophila protein related to AZI1 (CEP131) that is located at the ciliary base and required for cilium formationQ30502585
A proteomic analysis of human cilia: identification of novel componentsQ30841923
limmaGUI: a graphical user interface for linear modeling of microarray dataQ33205531
Cell cycle progression and de novo centriole assembly after centrosomal removal in untransformed human cellsQ33269437
An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63.Q33404354
Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryosQ33413993
Primary microcephaly: do all roads lead to Rome?Q33629131
Genome-wide transcriptional analysis of flagellar regeneration in Chlamydomonas reinhardtii identifies orthologs of ciliary disease genesQ33928536
Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cellsQ34207601
Cep120 is asymmetrically localized to the daughter centriole and is essential for centriole assembly.Q34218804
The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetriesQ34221115
Exploring the transcriptome of ciliated cells using in silico dissection of human tissuesQ34256530
Cep152 interacts with Plk4 and is required for centriole duplication.Q34317054
SAK/PLK4 is required for centriole duplication and flagella developmentQ34472675
The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epitheliaQ34502170
The genetics of developmental dyslexiaQ34529947
Flies without centriolesQ34543650
On the role of aurora-A in centrosome functionQ34818218
Foxj1 transcription factors are master regulators of the motile ciliogenic programQ34881332
SnapShot: centriole biogenesisQ34919184
Cell biology of normal and abnormal ciliogenesis in the ciliated epitheliumQ35739149
Molecular characterization of centriole assembly in ciliated epithelial cellsQ36118747
Controlling centrosome number: licenses and blocksQ36345293
Piecing together a ciliomeQ36543698
Centriole/basal body morphogenesis and migration during ciliogenesis in animal cellsQ36689663
Centriole and basal body formation during ciliogenesis revisitedQ36847218
Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathyQ37111349
Photoreceptor sensory cilia and inherited retinal degenerationQ37711181
1001 model organisms to study cilia and flagellaQ37833124
Centrosomes and cilia in human disease.Q37890619
Ultrastructure of cilia and flagella - back to the future!Q37897615
Molecular networks of DYX1C1 gene show connection to neuronal migration genes and cytoskeletal proteinsQ39265866
Proteomic analysis of isolated chlamydomonas centrioles reveals orthologs of ciliary-disease genesQ39720851
Human Protein Reference Database and Human Proteinpedia as discovery tools for systems biology.Q39950844
The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryosQ42158837
FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brainQ42462822
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that useslimmaQ112236343
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectTetratricopeptide repeat domain 12Q21123520
Myeloid leukemia factor 1Q21491064
Transformed mouse 3T3 cell double minute 1Q21982568
Tetratricopeptide repeat domain 12Q21987049
P304page(s)e52166
P577publication date2012-12-31
P1433published inPLOS OneQ564954
P1476titleTranscriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease
P478volume7

Reverse relations

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