Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells.

scientific article published on July 2013

Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCITRANSLMED.3006055
P932PMC publication ID3760005
P698PubMed publication ID23825301
P5875ResearchGate publication ID245029632

P50authorJames CostelloQ80183609
P2093author name stringJames J Collins
Orian S Shirihai
Marc Liesa
Catherine S Spina
J Ruben Morones-Ramirez
Anthony Molina
Shimyn Slomovic
Sameer Kalghatgi
P2860cites workMechanism of bactericidal action of aminoglycosides.Q39675399
Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell linesQ40211387
Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activationQ40490388
N-acetyl-l-cysteine.Q40865217
Delayed cytotoxicity and cleavage of mitochondrial DNA in ciprofloxacin-treated mammalian cells.Q41154998
Isolation of human cell lines lacking mitochondrial DNA.Q41244296
Nephrotoxicity of beta-lactam antibiotics: mechanisms and strategies for preventionQ41686944
Contribution of oxidative damage to antimicrobial lethality.Q41808795
The mitochondria targeted antioxidant MitoQ protects against fluoroquinolone-induced oxidative stress and mitochondrial membrane damage in human Achilles tendon cellsQ46113141
The mechanism of mitochondrial superoxide production by the cytochrome bc1 complexQ46560335
Interaction of beta-lactam antibiotics with the mitochondrial carnitine/acylcarnitine transporterQ46614628
H2S: a universal defense against antibiotics in bacteriaQ46754342
The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acidQ69353201
Killing by bactericidal antibiotics does not depend on reactive oxygen speciesQ86312935
Mitochondrial evolutionQ22065556
Inhibition of mammalian mitochondrial protein synthesis by oxazolidinonesQ24548260
New insights into the role of mitochondria in aging: mitochondrial dynamics and moreQ24600600
The fluoroquinolones: structures, mechanisms of action and resistance, and spectra of activity in vitroQ24670241
Inhibitory effects of quinolone antibacterial agents on eucaryotic topoisomerases and related test systemsQ24679491
A common mechanism of cellular death induced by bactericidal antibioticsQ28246128
GlutathioneQ28261279
Oxidation of the guanine nucleotide pool underlies cell death by bactericidal antibioticsQ28264943
Mitochondrial formation of reactive oxygen speciesQ29547906
Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicityQ30488706
Aminoglycosides: nephrotoxicityQ33605648
Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell deathQ33636218
Mitochondrial dysfunction in cardiac disease: ischemia--reperfusion, aging, and heart failureQ33953515
Fluoroquinolone-associated tendinopathy: a critical review of the literatureQ34199899
A murine model of urinary tract infectionQ34236010
Prevalence of mitochondrial DNA disease in adultsQ34691723
Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coliQ35742369
Proposed molecular and cellular mechanism for aminoglycoside ototoxicityQ35822046
Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals.Q36132703
Inhibitors of reactive oxygen species accumulation delay and/or reduce the lethality of several antistaphylococcal agents.Q36364252
Cell death from antibiotics without the involvement of reactive oxygen speciesQ37065875
Mistranslation of membrane proteins and two-component system activation trigger antibiotic-mediated cell death.Q37198083
Aminoglycoside-induced hearing loss in humansQ38676819
The mechanism of the irreversible antimicrobial effects of penicillins: how the beta-lactam antibiotics kill and lyse bacteriaQ39279622
P4510describes a project that usesImageJQ1659584
P433issue192
P407language of work or nameEnglishQ1860
P921main subjectmitochondrionQ39572
antibioticQ12187
P304page(s)192ra85
P577publication date2013-07-01
P1433published inScience Translational MedicineQ1573955
P1476titleBactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells
P478volume5

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