Neuromodulatory activities of CD4+CD25+ regulatory T cells in a murine model of HIV-1-associated neurodegeneration

scientific article published on March 2009

Neuromodulatory activities of CD4+CD25+ regulatory T cells in a murine model of HIV-1-associated neurodegeneration is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.0803330
P932PMC publication ID2661207
P698PubMed publication ID19265165
P5875ResearchGate publication ID24181001

P50authorHoward E. GendelmanQ64858836
P2093author name stringNan Gong
R Lee Mosley
Ashley D Reynolds
Jianuo Liu
Xiuyan Huang
P2860cites workCutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitisQ78404404
FOXP3 mRNA levels are decreased in peripheral blood CD4+ lymphocytes from HIV-positive patientsQ80358011
HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cellsQ24802813
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Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremiaQ28254584
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survivalQ29547865
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responsesQ29619908
Mononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infectionQ30883324
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Timed ablation of regulatory CD4+ T cells can prevent murine AIDS progressionQ34311400
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CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis.Q34544033
Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infectionQ34571341
Dementia and neurocognitive disorders due to HIV-1 infectionQ34602429
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HIV leucoencephalopathy and TNFalpha expression in neuronesQ35488817
Updated research nosology for HIV-associated neurocognitive disordersQ35755761
Human immunodeficiency virus encephalitis in SCID mice.Q35782070
HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS.Q35848896
Simian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeysQ35857361
HIV-1 infection and AIDS: consequences for the central nervous systemQ36098879
Inflammation and neuroaxonal injury in multiple sclerosis and AIDS dementia complex: implications for neuroprotective treatmentQ36247139
Mononuclear phagocytes in the pathogenesis of neurodegenerative diseasesQ36302045
Experimental and potential future therapeutic approaches for HIV-1 associated dementia targeting receptors for chemokines, glutamate and erythropoietinQ36302081
Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantationQ36370863
CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease statusQ36399748
Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitisQ36403300
Treg control of antimicrobial T cell responsesQ36450013
Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigensQ36954734
Defining and evaluating HIV-related neurodegenerative disease and its treatment targets: a combinatorial approach to use of cerebrospinal fluid molecular biomarkersQ37015519
Persistent intrathecal immune activation in HIV-1-infected individuals on antiretroviral therapyQ37066971
Neurobiology of HIV.Q37073645
Depletion of regulatory T cells in HIV infection is associated with immune activationQ38881101
The neuropathology of the acquired immune deficiency syndrome (AIDS). A reviewQ39644768
Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's diseaseQ40098160
An experimental model system for HIV-1-induced brain injuryQ40603263
In vivo modeling of HIV-1 mediated neurodegeneration.Q41089712
The neuropathogenesis of the AIDS dementia complex.Q41694913
Neuroregulatory events follow adaptive immune-mediated elimination of HIV-1-infected macrophages: studies in a murine model of viral encephalitis.Q42462823
Neuropathologic and neuroinflammatory activities of HIV-1-infected human astrocytes in murine brainQ42495493
Copolymer-1 induces adaptive immune anti-inflammatory glial and neuroprotective responses in a murine model of HIV-1 encephalitisQ42518980
Generation of cytotoxic T cells against virus-infected human brain macrophages in a murine model of HIV-1 encephalitis.Q42519857
Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responsesQ42947652
Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosisQ43583436
Elevated cerebrospinal fluid quinolinic acid levels are associated with region-specific cerebral volume loss in HIV infectionQ43596644
Quinolinic acid is produced by macrophages stimulated by platelet activating factor, Nef and Tat.Q43717545
Glucose-responsive expression of the human insulin promoter in HepG2 human hepatoma cellsQ44695816
Elevated levels of CD38+ CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: results of 6 years of follow-up. The Los Angeles Center, Multicenter AIDS Cohort StudyQ44715816
The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients.Q45304800
Enrichment and persistence of virus-specific CTL in the brain of simian immunodeficiency virus-infected monkeys is associated with a unique cytokine environment.Q45405005
Brain CD8+ and cytotoxic T lymphocytes are associated with, and may be specific for, human immunodeficiency virus type 1 encephalitis in patients with acquired immunodeficiency syndromeQ45412296
Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infectionQ45420228
Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patientsQ45609885
CD4+ and CD8+ cells accumulate in the brains of acquired immunodeficiency syndrome patients with human immunodeficiency virus encephalitisQ45729143
The validity of immunological studies in human immunodeficiency virus infection: a three-year follow-up of 235 homo- or bisexual personsQ45839302
The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1.Q45853669
Tumor-specific human CD4+ regulatory T cells and their ligands: implications for immunotherapyQ45871925
Neurocognitive dysfunction predicts postmortem findings of HIV encephalitisQ46470590
TNF-alpha-induced optic nerve degeneration and nuclear factor-kappaB p65.Q46614846
Functional impairment of CD8(+) T cells by regulatory T cells during persistent retroviral infectionQ47926468
The neuropathology of adult HIV infection.Q48291701
HIV-specific lymphoproliferative responses in asymptomatic HIV-infected individuals.Q52052815
Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART.Q52932694
Relationship of CD4+CD25+ regulatory T cells to immune status in HIV-infected patients.Q53674954
Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells.Q54656483
Laboratory investigations for the morphologic, pharmacokinetic, and anti-retroviral properties of indinavir nanoparticles in human monocyte-derived macrophagesQ56794691
Cell surface markers of regulatory T cells are not associated with increased forkhead box p3 expression in blood CD4+ T cells from HIV-infected patients responding to antiretroviral therapyQ60343443
AIDS dementia complexQ68490162
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectHIVQ15787
neurodegenerationQ1755122
murine modelQ122890741
P304page(s)3855-3865
P577publication date2009-03-01
P1433published inJournal of ImmunologyQ3521441
P1476titleNeuromodulatory activities of CD4+CD25+ regulatory T cells in a murine model of HIV-1-associated neurodegeneration
P478volume182

Reverse relations

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