Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis.

scientific article published on 18 September 2008

Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M804628200
P932PMC publication ID2662271
P698PubMed publication ID18801741

P50authorShinji HatakeyamaQ73231795
P2093author name stringKazutaka Ikeda
Ryo Taguchi
Yukio Ishikawa
Hiroyasu Sato
Kei Yamamoto
Makoto Murakami
Shuntaro Hara
Yoshitaka Taketomi
Hiroyuki Itabe
Kae Tsutsumi
Ichiro Kudo
Toshiharu Ishii
Tetsuyuki Kobayashi
Yuki Isogai
Rina Kato
Seiko Masuda
Mitsuhiro Ohtsuki
Joe Yamada
Go-ichi Saka
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Human group III phospholipase A2 suppresses adenovirus infection into host cells. Evidence that group III, V and X phospholipase A2s act on distinct cellular phospholipid molecular speciesQ40057599
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Atherogenic properties of LDL particles modified by human group X secreted phospholipase A2 on human endothelial cell function.Q40213725
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Elevated levels of small, low-density lipoprotein with high affinity for arterial matrix components in patients with rheumatoid arthritis: possible contribution of phospholipase A2 to this atherogenic profileQ43837372
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Protection against diet-induced obesity and obesity- related insulin resistance in Group 1B PLA2-deficient miceQ44176917
Macrophage-expressed group IIA secretory phospholipase A2 increases atherosclerotic lesion formation in LDL receptor-deficient miceQ44316915
Subtype-selective antagonists of lysophosphatidic Acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaquesQ44529184
Group V and X secretory phospholipase A(2)s-induced modification of high-density lipoprotein linked to the reduction of its antiatherogenic functionsQ44628275
Lysophosphatidylcholine regulates human microvascular endothelial cell expression of chemokinesQ44641329
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Reduction in myocardial ischemia/reperfusion injury in group X secretory phospholipase A2-deficient miceQ46573266
Differential hydrolysis of molecular species of lipoprotein phosphatidylcholine by groups IIA, V and X secretory phospholipases A2.Q46669673
Secretory phospholipase A2 and lipoprotein lipase enhance 15-lipoxygenase-induced enzymic and nonenzymic lipid peroxidation in low-density lipoproteinsQ47942846
A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmissionQ48952910
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Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction.Q52005910
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Impact of Phospholipase A2 group IIa gene polymorphism on phenotypic features of patients with familial adenomatous polyposis.Q54450457
Role of cytosolic phospholipase A2 in allergic response and parturitionQ59069879
Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5 , shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS studyQ61560054
Nondenaturing polyacrylamide gradient gel electrophoresisQ69553541
Transgenic model for the discovery of novel human secretory non-pancreatic phospholipase A2 inhibitorsQ71612327
A monoclonal antibody against oxidized lipoprotein recognizes foam cells in atherosclerotic lesions. Complex formation of oxidized phosphatidylcholines and polypeptidesQ72465733
Molecular basis for the association of group IIA phospholipase A(2) and decorin in human atherosclerotic lesionsQ73623179
Ultrastructural localization of secretory type II phospholipase A2 in atherosclerotic and nonatherosclerotic regions of human arteriesQ74471855
Expression of secretory phospholipase A2s in human atherosclerosis developmentQ79922608
Human group III secreted phospholipase A2 promotes neuronal outgrowth and survivalQ81294331
Deletion of secretory group V phospholipase A2 attenuates cell migration and airway hyperresponsiveness in immunosensitized miceQ81317312
Secretory phospholipase A2 group V: lesion distribution, activation by arterial proteoglycans, and induction in aorta by a Western dietQ83118082
P433issue48
P407language of work or nameEnglishQ1860
P921main subjectlipoproteinQ28350
atherosclerosisQ12252367
macrophageQ184204
P304page(s)33483-33497
P577publication date2008-09-18
P1433published inJournal of Biological ChemistryQ867727
P1476titleAnalyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis
P478volume283

Reverse relations

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