Innate immunity, macrophage activation, and atherosclerosis

scientific article published on October 2007

Innate immunity, macrophage activation, and atherosclerosis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1111/J.1600-065X.2007.00554.X
P698PubMed publication ID17850490

P2093author name stringGöran K Hansson
Zhong-qun Yan
P2860cites workA role for macrophage scavenger receptors in atherosclerosis and susceptibility to infectionQ59068486
Toll-like Receptor 4 Polymorphisms and AtherogenesisQ59273869
A frameshift mutation in NOD2 associated with susceptibility to Crohn's diseaseQ22251291
TLR4 mutations are associated with endotoxin hyporesponsiveness in humansQ22254186
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 GeneQ22299417
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaBQ24290546
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systemsQ24292468
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-betaQ24305136
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon inductionQ24318426
An endothelial receptor for oxidized low-density lipoproteinQ24323462
Nod1-mediated endothelial cell activation by Chlamydophila pneumoniaeQ24338210
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infectionQ24633526
AtherosclerosisQ24644573
Porphyromonas gingivalis fimbriae proactively modulate beta2 integrin adhesive activity and promote binding to and internalization by macrophagesQ24678639
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA virusesQ27860455
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responsesQ27860685
Pathogen recognition and innate immunityQ27861084
A human homologue of the Drosophila Toll protein signals activation of adaptive immunityQ28131769
Gout-associated uric acid crystals activate the NALP3 inflammasomeQ28131797
Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaBQ28142782
Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosisQ28198287
Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesisQ28205296
NALPs: a novel protein family involved in inflammationQ28206764
The PYRIN domain: a novel motif found in apoptosis and inflammation proteinsQ28206887
Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1Q28208472
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1Q28215427
Immune recognition. A new receptor for beta-glucansQ28215606
Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosisQ28236868
Interleukin-18 enhances atherosclerosis in apolipoprotein E(-/-) mice through release of interferon-gammaQ42162162
Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cellsQ42489719
Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophagesQ42826455
Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesisQ42944624
Porphyromonas gingivalis infection accelerates the progression of atherosclerosis in a heterozygous apolipoprotein E-deficient murine model.Q43531684
A role for oxidized phospholipids in atherosclerosisQ43686230
Hyaluronic acid and chondroitin sulphate A rapidly promote differentiation of immature DC with upregulation of costimulatory and antigen-presenting molecules, and enhancement of NF-kappaB and protein kinase activityQ43883899
Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient miceQ43893171
Overexpression of interleukin-10 by activated T lymphocytes inhibits atherosclerosis in LDL receptor-deficient Mice by altering lymphocyte and macrophage phenotypesQ44011973
Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in miceQ44079670
Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular diseaseQ44207349
Interleukin-1 receptor signaling mediates atherosclerosis associated with bacterial exposure and/or a high-fat diet in a murine apolipoprotein E heterozygote model: pharmacotherapeutic implicationsQ44278742
Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2.Q44459170
Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null miceQ44484471
Hyaluronan fragments stimulate endothelial recognition of injury through TLR4.Q44756938
The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis diseaseQ44773559
Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathwaysQ44807760
The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm.Q45025551
Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cellsQ45345622
A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarctionQ46155185
Porphyromonas gingivalis bacteremia induces coronary and aortic atherosclerosis in normocholesterolemic and hypercholesterolemic pigsQ46450288
Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null miceQ46551642
Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient miceQ47658739
Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45.Q51803715
Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors.Q51817209
A frequent toll-like receptor (TLR)-2 polymorphism is a risk factor for coronary restenosis.Q52938770
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and strokeQ56944340
Association of hypo-responsive toll-like receptor 4 variants with risk of myocardial infarction*1Q57607713
IL-18 Accelerates Atherosclerosis Accompanied by Elevation of IFN-γ and CXCL16 Expression Independently of T CellsQ57987937
Protective Role of Interleukin-10 in AtherosclerosisQ58150380
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenalQ28242907
Card9 controls a non-TLR signalling pathway for innate anti-fungal immunityQ28504584
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptorsQ28512624
RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophagesQ28568915
LOX-1 inhibition in myocardial ischemia-reperfusion injury: modulation of MMP-1 and inflammationQ28583634
Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectinsQ28588506
Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complexQ28588629
CD36 is a sensor of diacylglyceridesQ28591244
Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout miceQ28591350
Inflammation, atherosclerosis, and coronary artery diseaseQ29547232
Toll-like receptor control of the adaptive immune responsesQ29547305
Inflammation in atherosclerosisQ29547428
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirusQ29615029
Toll-like receptors and innate immunityQ29615458
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycanQ29618544
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acidQ29620015
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at largeQ33342232
Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST)Q33616752
Chlamydia pneumoniae augments the oxidized low-density lipoprotein-induced death of mouse macrophages by a caspase-independent pathwayQ33883485
Modulation of atherosclerosis in mice by Toll-like receptor 2Q34063165
Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2.Q34118046
NODs: intracellular proteins involved in inflammation and apoptosisQ34199862
Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cellsQ34325109
Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteinsQ34387116
The oxidative modification hypothesis of atherosclerosis: does it hold for humans?Q34423117
NOD-LRR proteins: role in host-microbial interactions and inflammatory diseaseQ34426050
Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance.Q34448382
Regulation of lung injury and repair by Toll-like receptors and hyaluronanQ34462186
Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disordersQ34472385
Circuitry of nuclear factor kappaB signalingQ34514908
CARD15 mutations in Blau syndromeQ34517310
Hyaluronan fragments act as an endogenous danger signal by engaging TLR2.Q34544391
The role of hyaluronan degradation products as innate alloimmune agonists.Q34574846
Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instabilityQ34601356
Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2.Q34858442
The macrophage foam cell as a target for therapeutic interventionQ34986351
Pattern recognition receptors: doubling up for the innate immune responseQ35036522
Chlamydia pneumoniae--an infectious risk factor for atherosclerosis?Q35701591
Expression of interleukin-15 in mouse and human atherosclerotic lesionsQ35747016
Dectin-1 is required for beta-glucan recognition and control of fungal infectionQ35837153
Macrophage receptors and immune recognitionQ36072472
No evidence of association between NOD2/CARD15 gene polymorphism and atherosclerotic events after renal transplantationQ36232292
Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2.Q36370968
CATERPILLERs, pyrin and hereditary immunological disordersQ36405072
Nucleotide-binding oligomerization domain-like receptors: intracellular pattern recognition molecules for pathogen detection and host defenseQ36584966
Nod-like proteins in immunity, inflammation and diseaseQ36655897
Myeloid C-type lectins in innate immunityQ36655901
Inflammasome adaptors and sensors: intracellular regulators of infection and inflammationQ36691082
Cooperation of Toll-like receptor signals in innate immune defenceQ36743540
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein EQ36986664
Antibiotic treatment of Chlamydia pneumoniae after acute coronary syndromeQ37865020
Azithromycin for the secondary prevention of coronary eventsQ37865023
Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling.Q37869249
Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathwaysQ37872216
Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathwayQ37872780
Predominant role of toll-like receptor 2 versus 4 in Chlamydia pneumoniae-induced activation of dendritic cellsQ37873504
Chlamydia pneumoniae infection does not induce or modify atherosclerosis in miceQ37874064
Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expressionQ37880399
Infection with Chlamydia pneumoniae accelerates the development of atherosclerosis and treatment with azithromycin prevents it in a rabbit modelQ37881464
Human cytomegalovirus envelope glycoproteins B and H are necessary for TLR2 activation in permissive cellsQ40212509
Adipocyte fatty acid-binding protein expression and lipid accumulation are increased during activation of murine macrophages by toll-like receptor agonists.Q40459587
CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor expressed in atherosclerotic lesionsQ40584986
Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 proteinQ40609759
Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol MetabolismQ40622775
Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored proteinQ40643736
Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signalingQ40662613
Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cellsQ40691206
Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cellsQ40799740
The extra domain A of fibronectin activates Toll-like receptor 4.Q40832345
Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary deathQ40993289
P407language of work or nameEnglishQ1860
P921main subjectatherosclerosisQ12252367
P304page(s)187-203
P577publication date2007-10-01
P1433published inImmunological ReviewsQ15724582
P1476titleInnate immunity, macrophage activation, and atherosclerosis
P478volume219

Reverse relations

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