Valproic acid activates the PI3K/Akt/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy

scientific article published on 29 January 2009

Valproic acid activates the PI3K/Akt/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2353/AJPATH.2009.080537
P932PMC publication ID2665759
P698PubMed publication ID19179609
P5875ResearchGate publication ID23959661

P50authorDean BurkinQ56759871
P2093author name stringJianming Liu
Stephen J Kaufman
Praveen B Gurpur
P2860cites workUtrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophyQ24310537
Gene expression comparison of biopsies from Duchenne muscular dystrophy (DMD) and normal skeletal muscleQ24538577
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivoQ28206290
Expression of alpha 7 integrin cytoplasmic domains during skeletal muscle development: alternate forms, conformational change, and homologies with serine/threonine kinases and tyrosine phosphatasesQ28250493
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cellsQ28366303
Role for the alpha7beta1 integrin in vascular development and integrityQ28504523
A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specificationQ28574258
Dystrophin: the protein product of the Duchenne muscular dystrophy locusQ29618077
The alpha7beta1 integrin in muscle development and diseaseQ33592124
Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and cyclin-dependent kinase inhibitor p21Q33966727
Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases.Q34065460
Transgenic expression of {alpha}7{beta}1 integrin maintains muscle integrity, increases regenerative capacity, promotes hypertrophy, and reduces cardiomyopathy in dystrophic miceQ35083511
Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitroQ36209334
Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx miceQ36324105
Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic miceQ36381102
Signaling pathways in skeletal muscle remodelingQ36498310
Increasing alpha 7 beta 1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expressionQ36995702
Laminin-111 restores regenerative capacity in a mouse model for alpha7 integrin congenital myopathyQ37073808
Myogenic Akt signaling regulates blood vessel recruitment during myofiber growth.Q39674949
Valproic acid-mediated Hsp70 induction and anti-apoptotic neuroprotection in SH-SY5Y cellsQ40346712
Serum protein binding and pharmacokinetics of valproate in man, dog, rat and mouseQ40849017
Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.Q40915594
Mechanism of activation and function of protein kinase B.Q41732739
Deacetylase inhibitors increase muscle cell size by promoting myoblast recruitment and fusion through induction of follistatinQ42829173
Alpha7beta1-integrin regulates mechanotransduction and prevents skeletal muscle injuryQ46900053
Valproic acid: metabolite concentrations in plasma and brain, anticonvulsant activity, and effects on GABA metabolism during subacute treatment in mice.Q48950581
Morphometric analysis of mdx diaphragm muscle fibres. Comparison with hindlimb musclesQ72427669
Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophyQ73677664
T-cell-dependent fibrosis in the mdx dystrophic mouseQ73952718
P4510describes a project that usesImageQuantQ112270642
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpathologyQ7208
P304page(s)999-1008
P577publication date2009-01-29
P1433published inThe American Journal of PathologyQ4744259
P1476titleValproic acid activates the PI3K/Akt/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy
P478volume174

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cites work (P2860)
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Q42639922Activation of AKT signaling promotes cell growth and survival in α7β1 integrin-mediated alleviation of muscular dystrophy
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Q35057217Autophagy is Impaired in the Tibialis Anterior of Dystrophin Null Mice
Q37944530Cell-matrix interactions in muscle disease
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Q60917438Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero
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Q35100070Interaction networks of lithium and valproate molecular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling
Q37137768Levels of α7 integrin and laminin-α2 are increased following prednisone treatment in the mdx mouse and GRMD dog models of Duchenne muscular dystrophy
Q84847497Local injections of adipose-derived mesenchymal stem cells modulate inflammation and increase angiogenesis ameliorating the dystrophic phenotype in dystrophin-deficient skeletal muscle
Q36179105Molecular and cellular mechanisms of skeletal muscle atrophy: an update.
Q21296867Molecular and therapeutic potential and toxicity of valproic acid
Q35011121Myotubularin regulates Akt-dependent survival signaling via phosphatidylinositol 3-phosphate
Q26769962Oxidative Stress-Mediated Skeletal Muscle Degeneration: Molecules, Mechanisms, and Therapies
Q33659344PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications
Q92489474Recent advances in Duchenne muscular dystrophy
Q45781418Repression of phosphatidylinositol transfer protein α ameliorates the pathology of Duchenne muscular dystrophy
Q58805825Secreted Frizzled-Related Protein-2 Inhibits Doxorubicin-Induced Apoptosis Mediated through the Akt-mTOR Pathway in Soleus Muscle
Q40133127Sodium valproate increases the brain isoform of glycogen phosphorylase: looking for a compensation mechanism in McArdle disease using a mouse primary skeletal-muscle culture in vitro.
Q35664342Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia
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Q90263455Valproic Acid Enhances Reprogramming Efficiency and Neuronal Differentiation on Small Molecules Staged-Induction Neural Stem Cells: Suggested Role of mTOR Signaling
Q28484912Valproic acid induces cutaneous wound healing in vivo and enhances keratinocyte motility
Q57040047Valproic acid is protective in cellular and worm models of oculopharyngeal muscular dystrophy
Q36717858Valproic acid suppresses collagen by selective regulation of Smads in conjunctival fibrosis

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