Current options in antifungal pharmacotherapy.

scientific article published on May 2008

Current options in antifungal pharmacotherapy. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1592/PHCO.28.5.614
P698PubMed publication ID18447660

P50authorLuis L Ostrosky-ZeichnerQ95627987
Melissa D. JohnsonQ50728607
P2093author name stringJohn Mohr
James S Lewis
Travis Cooper
P2860cites workDelaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortalityQ24530412
Phase 2, randomized, dose-ranging study evaluating the safety and efficacy of anidulafungin in invasive candidiasis and candidemiaQ24563657
A case of invasive aspergillosis in CGD patient successfully treated with Amphotericin B and INF-gammaQ24803510
The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthaseQ27932751
A randomized, double-blind, double-dummy, multicenter trial of voriconazole and fluconazole in the treatment of esophageal candidiasis in immunocompromised patientsQ28189320
NIAID Mycoses Study Group Multicenter Trial of Oral Itraconazole Therapy for Invasive AspergillosisQ42599568
Oral bioavailability of posaconazole in fasted healthy subjects: comparison between three regimens and basis for clinical dosage recommendationsQ42645346
The effect of ravuconazole on the pharmacokinetics of nelfinavir in healthy male volunteersQ42678650
Safety of long-term oral posaconazole use in the treatment of refractory invasive fungal infections.Q42686004
Multiple-dose pharmacokinetics and safety of the new antifungal triazole BAL4815 after intravenous infusion and oral administration of its prodrug, BAL8557, in healthy volunteersQ43094166
In vivo activity of interferon-gamma in combination with amphotericin B in the treatment of experimental cryptococcosisQ43423744
Aspergillus infection complicating cardiac transplantation. Report of five casesQ43472645
Risk factors for amphotericin B-induced nephrotoxicityQ43544333
A placebo-controlled trial of maintenance therapy with fluconazole after treatment of cryptococcal meningitis in the acquired immunodeficiency syndrome. California Collaborative Treatment GroupQ43574526
A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantationQ43619964
Randomized, double-blind clinical trial of amphotericin B colloidal dispersion vs. amphotericin B in the empirical treatment of fever and neutropeniaQ43628333
Congestive heart failure associated with itraconazoleQ43638251
Comparison of amphotericin B lipid complex (ABLC) vs. ambisome in the treatment of suspected or documented fungal infections in patients with leukemiaQ43653695
Decrease in Candida albicans strains with reduced susceptibility to fluconazole following changes in prescribing policiesQ43655282
Intravenous itraconazole followed by oral itraconazole in the treatment of invasive pulmonary aspergillosis in patients with hematologic malignancies, chronic granulomatous disease, or AIDS.Q43732838
Transient hypoparathyroidism due to amphotericin B-induced hypomagnesemia in a patient with beta-thalassemiaQ43748477
A randomized double-blind study of caspofungin versus amphotericin for the treatment of candidal esophagitisQ43757967
The epidemiology of nephrotoxicity associated with conventional amphotericin B therapyQ43797281
Intravenous and oral itraconazole versus intravenous and oral fluconazole for long-term antifungal prophylaxis in allogeneic hematopoietic stem-cell transplant recipients. A multicenter, randomized trialQ43801360
Fluconazole prophylaxis prevents intra-abdominal candidiasis in high-risk surgical patients.Q43823539
Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosisQ43864353
Cryptococcal meningitis: outcome in patients with AIDS and patients with neoplastic diseaseQ43945240
Safety and efficacy of liposomal amphotericin B compared with conventional amphotericin B for induction therapy of histoplasmosis in patients with AIDS.Q44064682
Reduced nephrotoxicity of conventional amphotericin B therapy after minimal nephroprotective measures: animal experiments and clinical studyQ44074398
Lipid formulations of amphotericins: are you a lumper or a splitter?Q44135232
A randomized double-blind study of caspofungin versus fluconazole for the treatment of esophageal candidiasisQ44166464
Infrequent occurrence of amphotericin B lipid complex-associated nephrotoxicity in various clinical settings at a university hospital: a retrospective studyQ44236247
Comparison of caspofungin and amphotericin B for invasive candidiasisQ44255071
Novel antifungal beta-amino acids: synthesis and activity against Candida albicansQ44301646
Continuous infusion of escalated doses of amphotericin B deoxycholate: an open-label observational studyQ44396642
Echinocandins: a new class of antifungalQ28201851
Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent feverQ28216366
Voriconazole versus amphotericin B for primary therapy of invasive aspergillosisQ28217179
Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trialQ28277029
Voriconazole versus a regimen of amphotericin B followed by fluconazole for candidaemia in non-neutropenic patients: a randomised non-inferiority trialQ28278518
Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropeniaQ28284944
Liposomal amphotericin B as initial therapy for invasive mold infection: a randomized trial comparing a high-loading dose regimen with standard dosing (AmBiLoad trial)Q28298468
Comparison of effects of amphotericin B deoxycholate infused over 4 or 24 hours: randomised controlled trialQ28359772
Risk factors of ventricular fibrillation during rapid amphotericin B infusionQ28362565
Double-blind placebo-controlled trial of fluconazole to prevent candidal infections in critically ill surgical patientsQ28362691
Long QT syndrome and torsade de pointes in a patient receiving fluconazoleQ28377092
Clinical significance of nephrotoxicity in patients treated with amphotericin B for suspected or proven aspergillosisQ28377349
Amphotericin B lipid complex (ABLC)-associated hypertension: case report and reviewQ28377356
Posaconazole as Salvage Treatment for Invasive Fusariosis in Patients with Underlying Hematologic Malignancy and Other ConditionsQ29399166
Antifungal susceptibility survey of 2,000 bloodstream Candida isolates in the United States.Q30452376
Trends in antifungal susceptibility of Candida spp. isolated from pediatric and adult patients with bloodstream infections: SENTRY Antimicrobial Surveillance Program, 1997 to 2000.Q30453032
Amphotericin B colloidal dispersion (Amphocil) vs fluconazole for the prevention of fungal infections in neutropenic patients: data of a prematurely stopped clinical trialQ30596268
Aspergillosis case-fatality rate: systematic review of the literatureQ31918085
Clinical efficacy of amphotericin B colloidal dispersion against infections caused by Aspergillus spp.Q33679625
Efficacy, plasma pharmacokinetics, and safety of icofungipen, an inhibitor of Candida isoleucyl-tRNA synthetase, in treatment of experimental disseminated candidiasis in persistently neutropenic rabbitsQ33770019
Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. National Institute of Allergy and Infectious Diseases Mycoses Study GroupQ33854646
Practice guidelines for diseases caused by Aspergillus. Infectious Diseases Society of AmericaQ33894472
Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of AmericaQ33898624
A multicenter, open-label clinical study of micafungin (FK463) in the treatment of deep-seated mycosis in JapanQ33980368
Safety, tolerance, and pharmacokinetics of high-dose liposomal amphotericin B (AmBisome) in patients infected with Aspergillus species and other filamentous fungi: maximum tolerated dose studyQ33983629
Invasive aspergillosis. Disease spectrum, treatment practices, and outcomes. I3 Aspergillus Study GroupQ34002098
Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasisQ34006585
Antifungal pharmacodynamics: review of the literature and clinical applicationsQ34083129
Randomized, double-blind, multicenter study of caspofungin versus amphotericin B for treatment of oropharyngeal and esophageal candidiasesQ34105475
2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancerQ34114674
Prior antimicrobial therapy and risk for hospital-acquired Candida glabrata and Candida krusei fungemia: a case-case-control studyQ34123634
Discontinuation of secondary prophylaxis for cryptococcal meningitis in human immunodeficiency virus-infected patients treated with highly active antiretroviral therapy: a prospective, multicenter, randomized studyQ34196792
Glucan synthase inhibitors as antifungal agentsQ34236665
Direct vasoconstriction as a possible cause for amphotericin B-induced nephrotoxicity in ratsQ34265019
Pharmacology of Systemic Antifungal AgentsQ57533011
A phase I/II randomized, double-blind, placebo-controlled, dose-ranging study evaluating the efficacy, safety and pharmacokinetics of ravuconazole in the treatment of onychomycosisQ58404248
An open study on the safety and efficacy of fluconazole in the treatment of disseminated Candida infections in patients treated for hematological malignancyQ58840045
Seroincidence of Coccidioidomycosis during military desert training exercisesQ37576864
Effect of salt supplementation on amphotericin B nephrotoxicityQ39185944
Prevention of amphotericin B-induced renal impairment. A review on the use of sodium supplementationQ39540249
Paradoxical effect of caspofungin: reduced activity against Candida albicans at high drug concentrationsQ39954432
Single-dose pharmacokinetics and tolerance of a cholesteryl sulfate complex of amphotericin B administered to healthy volunteersQ40284175
Effect of infusion rates on toxicity of amphotericin B.Q40284666
Fluconazole prophylaxis in critically ill surgical patients: a meta-analysisQ40390928
Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropeniaQ40524745
Low-dose amphotericin B lipid complex vs. conventional amphotericin B for empirical antifungal therapy of neutropenic fever in patients with hematologic malignancies--a randomized, controlled trialQ40536892
A double-blind, randomized, controlled trial of amphotericin B colloidal dispersion versus amphotericin B for treatment of invasive aspergillosis in immunocompromised patientsQ40577742
Intravenous and oral itraconazole versus intravenous amphotericin B deoxycholate as empirical antifungal therapy for persistent fever in neutropenic patients with cancer who are receiving broad-spectrum antibacterial therapy. A randomized, controlleQ40596481
A randomized, double-blind comparative trial evaluating the safety of liposomal amphotericin B versus amphotericin B lipid complex in the empirical treatment of febrile neutropenia. L Amph/ABLC Collaborative Study GroupQ40612309
Coccidioidomycosis in patients infected with human immunodeficiency virus: review of 91 cases at a single institutionQ40664606
In vitro activity of ravuconazole against 923 clinical isolates of nondermatophyte filamentous fungi.Q40668115
Pretreatment regimens for adverse events related to infusion of amphotericin B.Q40686510
Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopeniaQ40847963
Meperidine for the treatment of shaking chills and feverQ40862172
Management of invasive candidal infections: results of a prospective, randomized, multicenter study of fluconazole versus amphotericin B and review of the literatureQ41218000
A Comparison of Amphotericin B Alone and Combined with Flucytosine in the Treatment of Cryptoccal MeningitisQ41644134
Refractory mucosal candidiasis in advanced human immunodeficiency virus infection.Q41736571
Sodium protects against nephrotoxicity in patients receiving amphotericin B.Q42196559
Risk factors for Amphotericin B-associated nephrotoxicityQ42199876
Must we really fear toxicity of conventional amphotericin B in oncological patients?Q42536416
Phase I study of amphotericin B colloidal dispersion for the treatment of invasive fungal infections after marrow transplantQ42556554
Intravenous itraconazoleQ34284268
Posaconazole as salvage therapy for zygomycosisQ34301611
Pharmacokinetics, safety, and efficacy of posaconazole in patients with persistent febrile neutropenia or refractory invasive fungal infectionQ34352014
Pharmacodynamic activity of amphotericin B deoxycholate is associated with peak plasma concentrations in a neutropenic murine model of invasive pulmonary aspergillosisQ34352109
Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantationQ34368144
Correlates of acute renal failure in patients receiving parenteral amphotericin B.Q34384041
Epidemiology and outcome of zygomycosis: a review of 929 reported casesQ34440240
Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus.Q34455633
Intrathecal amphotericin in the management of coccidioidal meningitisQ34461613
Infection in organ-transplant recipientsQ34471508
Fluconazole for the management of invasive candidiasis: where do we stand after 15 years?Q34490092
Disseminated phaeohyphomycosis: review of an emerging mycosisQ34498615
Posaconazole is effective as salvage therapy in zygomycosis: a retrospective summary of 91 casesQ34498982
Long QTc interval and torsade de pointes caused by fluconazoleQ34569221
Posaconazole or fluconazole for prophylaxis in severe graft-versus-host diseaseQ34574325
Anidulafungin versus fluconazole for invasive candidiasisQ34580316
State-of-the-art review of pulmonary fungal infectionsQ34692250
Histoplasmosis and blastomycosisQ34734019
Safety and tolerability of caspofungin acetate in the treatment of fungal infectionsQ34746958
Voriconazole: a new triazole antifungal agentQ35069136
Caspofungin: the first in a new class of antifungal agentsQ35214623
Randomized, double-blind trial of 1- versus 4-hour amphotericin B infusion durationsQ35565314
New approaches to the risk of Candida in the intensive care unitQ35587111
QT prolongation with antimicrobial agents: understanding the significanceQ35771493
Double-blind randomized study of the effect of infusion rates on toxicity of amphotericin BQ35843584
Prophylaxis and treatment of invasive candidiasis in the intensive care settingQ35889819
Retrospective study of the hepatic safety profile of patients concomitantly treated with caspofungin and cyclosporin A.Q35966128
Invasive candidiasis in the intensive care unitQ36408361
Zygomycosis: the re-emerging fungal infectionQ36433729
Attributable mortality of candidemia: a systematic review of matched cohort and case-control studiesQ36506378
Severe hypertension associated with the use of amphotericin B: an appraisal on the reported casesQ36516342
Invasive aspergillosis following hematopoietic cell transplantation: outcomes and prognostic factors associated with mortalityQ36715387
Mechanisms of amphotericin B-induced decrease in glomerular filtration rate in ratsQ36757423
Triad of Acute Infusion‐Related Reactions Associated with Liposomal Amphotericin B: Analysis of Clinical and Epidemiological CharacteristicsQ44440957
A randomized and blinded multicenter trial of high-dose fluconazole plus placebo versus fluconazole plus amphotericin B as therapy for candidemia and its consequences in nonneutropenic subjects.Q44440960
Treatment of cryptococcal meningitis associated with the acquired immunodeficiency syndrome. National Institute of Allergy and Infectious Diseases Mycoses Study Group and AIDS Clinical Trials GroupQ44474075
Amphotericin B: time for a new "gold standard".Q44527998
Effects of amphotericin B and caspofungin on histamine expressionQ44551295
The solubility ceiling: a rationale for continuous infusion amphotericin B therapy?Q44573526
Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplantsQ44606439
Itraconazole prevents invasive fungal infections in neutropenic patients treated for hematologic malignancies: evidence from a meta-analysis of 3,597 patientsQ44691631
Lipid formulations of amphotericin B preserve and stabilize renal function in HSCT recipientsQ44733428
Fluconazole compared with ketoconazole for the treatment of Candida esophagitis in AIDS. A randomized trialQ44753214
Risk factors of invasive aspergillosis after heart transplantation: protective role of oral itraconazole prophylaxisQ44800864
Liposomal amphotericin B (AmBisome) compared with amphotericin B both followed by oral fluconazole in the treatment of AIDS-associated cryptococcal meningitis.Q44952024
Prophylaxis for invasive candidiasis in the intensive care unit: is it time?Q44970985
Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activityQ45066131
A randomized, double-blind trial of anidulafungin versus fluconazole for the treatment of esophageal candidiasisQ45096984
Combination antifungal therapy for invasive aspergillosisQ45096994
A randomized, double-blind, parallel-group, dose-response study of micafungin compared with fluconazole for the treatment of esophageal candidiasis in HIV-positive patientsQ45097002
Randomized comparison between fluconazole and itraconazole for the treatment of candidemia in a pediatric intensive care unit: a preliminary studyQ45141879
Retrospective study of the renal effects of amphotericin B lipid complex when used at higher-than-recommended dosages and longer durations compared with lower dosages and shorter durations in patients with systemic fungal infectionsQ45186788
Treatment of Chronic Pulmonary HistoplasmosisQ45216504
Comparison of the efficacy of amphotericin B and fluconazole in the treatment of cryptococcosis in human immunodeficiency virus-negative patients: retrospective analysis of 83 cases. French Cryptococcosis Study GroupQ45769494
Effects of hydration with salt repletion on renal toxicity of conventional amphotericin B empirical therapy: a prospective study in patients with hematological malignanciesQ46366403
A randomized, double blind, comparative trial of micafungin (FK463) vs. fluconazole for the treatment of oesophageal candidiasis.Q46414215
Treatment of Candida infections with amphotericin B lipid complexQ46421806
Amphotericin B lipid complex in the management of invasive aspergillosis in immunocompromised patientsQ46421810
Treatment of non-Aspergillus moulds in immunocompromised patients, with amphotericin B lipid complexQ46421814
Study of renal safety in amphotericin B lipid complex-treated patientsQ46421821
Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infectionQ46486677
Refractory coccidioidomycosis treated with posaconazoleQ46503391
In vitro activities of new and established triazoles against opportunistic filamentous and dimorphic fungiQ46595795
Activity of aminocandin (IP960) compared with amphotericin B and fluconazole in a neutropenic murine model of disseminated infection caused by a fluconazole-resistant strain of Candida tropicalisQ46620841
A randomized study of the use of fluconazole in continuous versus episodic therapy in patients with advanced HIV infection and a history of oropharyngeal candidiasis: AIDS Clinical Trials Group Study 323/Mycoses Study Group Study 40.Q46758165
International, open-label, noncomparative, clinical trial of micafungin alone and in combination for treatment of newly diagnosed and refractory candidemia.Q46784358
Fluconazole prophylaxis for critically ill patients at high risk for Candida infectionQ46788982
In vitro activity of a new triazole BAL4815, the active component of BAL8557 (the water-soluble prodrug), against Aspergillus spp.Q46801074
Investigation of the potential relationships between plasma voriconazole concentrations and visual adverse events or liver function test abnormalitiesQ46908044
Secular trend of hospital-acquired candidemia among intensive care unit patients in the United States during 1989-1999.Q50700185
Interferon-gamma therapy in two patients with progressive chronic pulmonary aspergillosis.Q51187145
Micafungin (FK463), alone or in combination with other systemic antifungal agents, for the treatment of acute invasive aspergillosis.Q51187346
A randomized, blinded, multicenter trial of lipid-associated amphotericin B alone versus in combination with an antibody-based inhibitor of heat shock protein 90 in patients with invasive candidiasis.Q51187404
The epidemiology and attributable outcomes of candidemia in adults and children hospitalized in the United States: a propensity analysis.Q51188122
Risk factors for invasive fungal infections complicating orthotopic liver transplantation.Q51195234
Treatment of cryptococcal meningitis with combination amphotericin B and flucytosine for four as compared with six weeks.Q52073846
An EORTC international multicenter randomized trial (EORTC number 19923) comparing two dosages of liposomal amphotericin B for treatment of invasive aspergillosis.Q53349495
Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases.Q53950594
Itraconazole therapy for blastomycosis and histoplasmosis. NIAID Mycoses Study GroupQ54057550
Efficacy and safety of fluconazole prophylaxis for fungal infections after marrow transplantation--a prospective, randomized, double-blind study.Q54171057
Potassium depletion potentiates amphotericin-B-induced toxicity to renal tubules.Q54188180
Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: a phase III randomised double-blind trialQ56970523
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectpharmacotherapyQ701216
P304page(s)614-645
P577publication date2008-05-01
P1433published inPharmacotherapyQ7180800
P1476titleCurrent options in antifungal pharmacotherapy
P478volume28

Reverse relations

cites work (P2860)
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