Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial

scientific article

Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1086/508774
P3181OpenCitations bibliographic resource ID1790845
P698PubMed publication ID17143808
P5875ResearchGate publication ID6654844

P50authorJo-Anne H. YoungQ22073689
Raoul HerbrechtQ37841047
Thomas F PattersonQ56859142
John R PerfectQ64932411
Susan HadleyQ87960667
Pranatharthi ChandrasekarQ95946224
Issam I RaadQ102052591
Thomas J WalshQ108430075
Brahm H SegalQ114294204
Patricia RibaudQ114324338
Gerald R DonowitzQ114412694
Arnold LouieQ125021748
P2093author name stringDavid A Stevens
Gopal Krishna
Ray Hachem
Charles S White
Lisa Pedicone
Amelia Langston
Reginald E Greene
Jagadish Gogate
Gavin Corcoran
Catherine Hardalo
Richard Graybill
P2860cites workVoriconazole versus amphotericin B for primary therapy of invasive aspergillosisQ28217179
Antifungal activity and pharmacokinetics of posaconazole (SCH 56592) in treatment and prevention of experimental invasive pulmonary aspergillosis: correlation with galactomannan antigenemiaQ28349552
Efficacy of SCH56592 in a rabbit model of invasive aspergillosisQ33979027
Invasive aspergillosis. Disease spectrum, treatment practices, and outcomes. I3 Aspergillus Study GroupQ34002098
Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus.Q34455633
Aspergillosis. Pathogenesis, clinical manifestations, and therapyQ35038459
Review of the safety, tolerability, and drug interactions of the new antifungal agents caspofungin and voriconazoleQ35169486
Voriconazole: therapeutic review of a new azole antifungalQ35917452
Opportunistic mycoses in the immunocompromised host: experience at a cancer center and reviewQ35997161
Activity of posaconazole combined with amphotericin B against Aspergillus flavus infection in mice: comparative studies in two laboratoriesQ36491145
Disposition of posaconazole following single-dose oral administration in healthy subjectsQ39955617
Efficacy of posaconazole in a murine model of central nervous system aspergillosisQ40164914
Five-year-survey of invasive aspergillosis in a paediatric cancer centre. Epidemiology, management and long-term survivalQ40630645
NIAID Mycoses Study Group Multicenter Trial of Oral Itraconazole Therapy for Invasive AspergillosisQ42599568
Experimental pulmonary aspergillosis due to Aspergillus terreus: pathogenesis and treatment of an emerging fungal pathogen resistant to amphotericin B.Q43517131
Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosisQ43864353
Efficacy and safety of caspofungin for treatment of invasive aspergillosis in patients refractory to or intolerant of conventional antifungal therapyQ45172488
Aspergillus nidulans Infection in Chronic Granulomatous DiseaseQ57908366
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectaspergillosisQ259626
invasive aspergillosisQ3625278
P1104number of pages11
P304page(s)2-12
P577publication date2007-01-01
P1433published inClinical Infectious DiseasesQ5133764
P1476titleTreatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial
P478volume44

Reverse relations

cites work (P2860)
Q88523381A Population Pharmacokinetic Model for a Solid Oral Tablet Formulation of Posaconazole
Q90254018A Prospective Real-World Study of the Impact of an Antifungal Stewardship Program in a Tertiary Respiratory-Medicine Setting
Q28388755A case report of inhalation anthrax acquired naturally
Q36265747A case report of intravenous posaconazole in hepatic and renal impairment patient with invasive Aspergillus terreus infection: safety and role of therapeutic drug monitoring
Q91777235A clinical approach to respiratory disease in patients with hematological malignancy, with a focus on respiratory infection
Q39653780A multicenter, open-label study of posaconazole oral suspension in the treatment of invasive fungal infections in patients refractory to or intolerant of first-line therapy.
Q36308059A new solid oral tablet formulation of posaconazole: a randomized clinical trial to investigate rising single- and multiple-dose pharmacokinetics and safety in healthy volunteers
Q64120981A non-randomized trial to assess the safety, tolerability, and pharmacokinetics of posaconazole oral suspension in immunocompromised children with neutropenia
Q38483558A randomized, placebo- and active-controlled, parallel-group, multicentre, investigator-blinded study of four treatment regimens of posaconazole in adults with toenail onychomycosis
Q41907424A reference laboratory experience of clinically achievable voriconazole, posaconazole, and itraconazole concentrations within the bloodstream and cerebral spinal fluid
Q33385491A risk profile for invasive aspergillosis in liver transplant recipients
Q40039262Acute myeloid leukemia and the infectious diseases consultant
Q53127302Adherence to recommendations for the use of antifungal agents in a tertiary care hospital.
Q46763769Aggressive cutaneous squamous cell carcinoma associated with prolonged voriconazole therapy in a renal transplant patient
Q46788198Amphotericin B lipid complex versus liposomal amphotericin B monotherapy for invasive aspergillosis in patients with hematologic malignancy
Q54394711An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients.
Q34452574Analysis of posaconazole as oral antifungal prophylaxis in pediatric patients under 12 years of age following allogeneic stem cell transplantation
Q52936136Analysis of the clinical features of invasive bronchopulmonary aspergillosis.
Q37159568Antifungal agents--clinical pharmacokinetics and drug interactions
Q34400255Antifungal clinical trials and guidelines: what we know and do not know
Q37816399Antifungal prophylaxis and therapy in patients with hematological malignancies and hematopoietic stem cell transplant recipients
Q37866827Antifungal prophylaxis during treatment for haematological malignancies: are we there yet?
Q38944746Antifungal stewardship considerations for adults and pediatrics
Q37310029Antifungal therapeutic drug monitoring: established and emerging indications
Q37161793Antifungal therapies in the intensive care unit
Q37421528Antifungal therapy for invasive fungal diseases in allogeneic stem cell transplant recipients: an update
Q36591360Antifungal therapy in febrile neutropenic patients: review of treatment choices and strategies for aspergillar infection
Q57549163Antimicrobial Agents
Q37048679Antimicrobial resistance: resistance to antifungal agents: mechanisms and clinical impact
Q37772501Approaches to the early treatment of invasive fungal infection
Q47645142Aspergillosis in Chronic Granulomatous Disease.
Q39987609Aspergillosis in hematopoietic stem cell transplant recipients: risk factors, prophylaxis, and treatment
Q42272291Aspergillosis in solid organ transplantation
Q37101166Aspergillus tracheobronchitis causing subtotal tracheal stenosis in a liver transplant recipient
Q38406393Azole antifungals: 35 years of invasive fungal infection management
Q40435009Blood and tissue distribution of posaconazole in a rat model of invasive pulmonary aspergillosis
Q46567838Breakthrough disseminated Scedosporium prolificans infection in a patient with relapsed leukaemia on prolonged voriconazole followed by posaconazole prophylaxis
Q80778520Breakthrough infection of Trichosporon asahii during posaconazole treatment in a patient with acute myeloid leukaemia
Q52593361CYP51 as drug targets for fungi and protozoan parasites: past, present and future.
Q37159584Caspofungin for treatment of invasive aspergillus infections.
Q93078617Central Nervous System Infections Due to Aspergillus and Other Hyaline Molds
Q36920608Changing epidemiology of rare mould infections: implications for therapy
Q37081683Changing landscape of invasive aspergillosis in allogeneic stem cell transplant recipients
Q58701142Clinical Outcomes of Oral Suspension versus Delayed-Release Tablet Formulations of Posaconazole for Prophylaxis of Invasive Fungal Infections
Q38871233Clinical evidence for caspofungin monotherapy in the first-line and salvage therapy of invasive Aspergillus infections.
Q34546811Clinical hepatotoxicity associated with antifungal agents
Q42413286Clinical pharmacodynamics and pharmacokinetics of the antifungal extended‐spectrum triazole posaconazole: an overview
Q35026481Clinical safety and tolerability issues in use of triazole derivatives in management of fungal infections.
Q37000091Combination antifungal therapy for the treatment of invasive yeast and mold infections
Q40841377Comparison of posaconazole serum concentrations from haematological cancer patients on posaconazole tablet and oral suspension for treatment and prevention of invasive fungal infections
Q39026820Comparison of serum concentrations between different dosing strategies of posaconazole delayed-release tablet at a large academic medical centre
Q37775500Conazoles.
Q37373785Concurrent lung infections in patients with hematological malignancies and invasive pulmonary aspergillosis: how firm is the Aspergillus diagnosis?
Q38284468Consensus guidelines for optimising antifungal drug delivery and monitoring to avoid toxicity and improve outcomes in patients with haematological malignancy, 2014.
Q38284463Consensus guidelines for the treatment of invasive mould infections in haematological malignancy and haemopoietic stem cell transplantation, 2014.
Q45861947Cost of invasive fungal infections in the era of new diagnostics and expanded treatment options
Q37079099Current and future therapeutic options in the management of invasive aspergillosis
Q37402524Current approaches in antifungal prophylaxis in high risk hematologic malignancy and hematopoietic stem cell transplant patients
Q37908856Current concepts in antifungal pharmacology
Q37151326Current options in antifungal pharmacotherapy.
Q39269082Cutaneous Toxicities From Transplantation-Related Medications
Q104492457Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance
Q37164085Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria
Q46273412Development and validation of a high-performance liquid chromatography assay for posaconazole utilizing solid-phase extraction
Q37813420Development, clinical utility, and place in therapy of posaconazole for prevention and treatment of invasive fungal infections
Q37889382Diagnosis and therapy of Candida infections: joint recommendations of the German Speaking Mycological Society and the Paul-Ehrlich-Society for Chemotherapy
Q36862446Diagnosis and treatment of mucormycosis in patients with hematological malignancies: guidelines from the 3rd European Conference on Infections in Leukemia (ECIL 3).
Q39443748Drug-drug interactions between triazole antifungal agents used to treat invasive aspergillosis and immunosuppressants metabolized by cytochrome P450 3A4.
Q36111766Economic evaluation of posaconazole versus standard azole therapy as prophylaxis against invasive fungal infections in patients with prolonged neutropenia in Canada
Q35607672Effect of a high-fat meal on the pharmacokinetics of 300-milligram posaconazole in a solid oral tablet formulation
Q41767156Effect of calcineurin inhibitors on posaconazole blood levels as measured by the MVista microbiological assay
Q48202863Effect of posaconazole on the pharmacokinetics of simvastatin and midazolam in healthy volunteers
Q37409875Effect of varying amounts of a liquid nutritional supplement on the pharmacokinetics of posaconazole in healthy volunteers
Q35635971Effects of age, gender, and race/ethnicity on the pharmacokinetics of posaconazole in healthy volunteers
Q37944001Efficacy and safety of current drug therapies for invasive aspergillosis
Q40062960Efficacy and safety of posaconazole in hematopoietic stem cell transplantation patients with invasive fungal disease
Q41175826Efficacy of antifungal prophylaxis with oral suspension posaconazole during induction chemotherapy of acute myeloid leukemia
Q37779496Efficacy of caspofungin as salvage therapy for invasive aspergillosis compared to standard therapy in a historical cohort
Q42109334Efficacy of posaconazole as treatment and prophylaxis against Fusarium solani
Q51042801Environmental fungicides and triazole resistance in Aspergillus.
Q35089772Epidemiology and treatment approaches in management of invasive fungal infections
Q38135904Epidemiology and treatment of mucormycosis
Q40112567Evaluation of Posaconazole Serum Concentrations from Delayed-Release Tablets in Patients at High-Risk for Fungal Infections
Q36076106Evaluation of Sulfobutylether-β-Cyclodextrin Exposure in a Critically Ill Patient Receiving Intravenous Posaconazole While Undergoing Continuous Venovenous Hemofiltration
Q47098888Exposure-Response Relationships for Isavuconazole in Patients with Invasive Aspergillosis and Other Filamentous Fungi.
Q37761047Exposure-response of posaconazole used for prophylaxis against invasive fungal infections: evaluating the need to adjust doses based on drug concentrations in plasma
Q90577176Extrapolating Antifungal Animal Data to Humans - Is it reliable?
Q33867013Factors associated with mortality in transplant patients with invasive aspergillosis
Q35065903Failure of posaconazole therapy in a renal transplant patient with invasive aspergillosis due to Aspergillus fumigatus with attenuated susceptibility to posaconazole
Q41354303Fatal Breakthrough Mucormycosis in an Acute Myelogenous Leukemia Patient while on Posaconazole Prophylaxis.
Q34427584Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or allogeneic haemopoietic stem-cell transplantation
Q47580986Fungal Prophylaxis with a Gastro-Resistant Posaconazole Tablet for Patients with Hematological Malignancies in the POSANANTES Study
Q37739908Fungal infections after hematopoietic stem cell transplantation
Q38202571Fungal infections in cancer patients
Q37058527Fungal infections in intensive care unit: challenges in diagnosis and management
Q36841586Fungal infections in primary immunodeficiencies
Q51184875Fungal infections in recipients of hematopoietic stem cell transplants: results of the SEIFEM B-2004 study--Sorveglianza Epidemiologica Infezioni Fungine Nelle Emopatie Maligne.
Q33896940Fungal infections in transplant and oncology patients
Q38252946Fungal infections of the skin and nail: new treatment options.
Q37060071Fungal rhinosinusitis and imaging modalities
Q37123394Fungicidal versus Fungistatic: what's in a word?
Q37904672Has the era of individualised medicine arrived for antifungals? A review of antifungal pharmacogenomics.
Q64982266Hepatotoxicity Due to Azole Antimycotic Agents in a HLA B*35:02-Positive Patient.
Q39755518High weekly doses of liposomal amphotericin B as secondary prophylaxis after cerebral aspergillosis in a paediatric patient
Q42314358Hypokalemia and Hypertension Associated with Supratherapeutic Posaconazole Levels.
Q80383094Immune reconstitution inflammatory syndrome in cancer patients with pulmonary aspergillosis recovering from neutropenia: Proof of principle, description, and clinical and research implications
Q42939581Impact of glucuronide interferences on therapeutic drug monitoring of posaconazole by tandem mass spectrometry.
Q37263430Impact of in vivo triazole and echinocandin combination therapy for invasive pulmonary aspergillosis: enhanced efficacy against Cyp51 mutant isolates
Q92872635Implications for IV posaconazole dosing in the era of obesity
Q40202912In Vivo 11β-Hydroxysteroid Dehydrogenase Inhibition in Posaconazole-Induced Hypertension and Hypokalemia
Q42950831In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from Japan
Q45238820In vitro antifungal activity of isavuconazole against 345 mucorales isolates collected at study centers in eight countries.
Q63379731Inadequate diagnostics: the case to move beyond the bacilli for detection of meningitis due to Mycobacterium tuberculosis
Q30235457Intensive care medicine research agenda on invasive fungal infection in critically ill patients
Q58775551Invasive Aspergillosis in Children: Update on Current Guidelines
Q64229013Invasive Aspergillosis in Pediatric Leukemia Patients: Prevention and Treatment
Q37954958Invasive aspergillosis in children with acquired immunodeficiencies
Q37854719Invasive aspergillosis in children with hematological malignancies
Q33800526Invasive aspergillosis in patients with acute myeloid leukemia: a SEIFEM-2008 registry study
Q28306909Invasive aspergillosis in the intensive care unit
Q36895540Invasive aspergillosis: epidemiology, diagnosis and management in immunocompromised patients
Q38110850Invasive candidiasis: update on current pharmacotherapy options and future perspectives
Q34288593Invasive fungal breakthrough infections, fungal colonization and emergence of resistant strains in high-risk patients receiving antifungal prophylaxis with posaconazole: real-life data from a single-centre institutional retrospective observational s
Q38151663Invasive fungal infections
Q34461693Invasive fungal infections in solid organ transplant recipients
Q37306108Invasive opportunistic mycoses: clinical trials review, 2007-2008.
Q88595472Isavuconazole Concentration in Real-World Practice: Consistency with Results from Clinical Trials
Q40865179Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial
Q34900399Isavuconazole: a new and promising antifungal triazole for the treatment of invasive fungal infections
Q37916824Italian guidelines for diagnosis, prevention, and treatment of invasive fungal infections in solid organ transplant recipients
Q92707809Low Central Nervous System Posaconazole Concentrations during Cerebral Phaeohyphomycosis
Q37345694Lung infections after cancer chemotherapy
Q37202860Management of fungal infections following allogeneic stem cell transplantation
Q36087577Management of invasive pulmonary aspergillosis in non-neutropenic critically ill patients
Q36364013Multicenter study of posaconazole therapeutic drug monitoring: exposure-response relationship and factors affecting concentration.
Q38802008Multicentre study of posaconazole delayed-release tablet serum level and association with hepatotoxicity and QTc prolongation.
Q34309603Multiplex ultra-performance liquid chromatography-tandem mass spectrometry method for simultaneous quantification in human plasma of fluconazole, itraconazole, hydroxyitraconazole, posaconazole, voriconazole, voriconazole-N-oxide, anidulafungin, and
Q37364295New and investigational triazole agents for the treatment of invasive fungal infections
Q38797864New facets of antifungal therapy
Q37579222New generation azole antifungals in clinical investigation
Q46112222Novel Approaches to Antifungal Therapy
Q46840248Novel antifungal agents as salvage therapy for invasive aspergillosis in patients with hematologic malignancies: posaconazole compared with high-dose lipid formulations of amphotericin B alone or in combination with caspofungin
Q37786165Opportunistic Fungi: A View to the Future
Q50519900Optimising absorption of posaconazole.
Q37552818Other HIV-associated pneumonias
Q35584615Outcome analysis of invasive aspergillosis in hematologic malignancy and hematopoietic stem cell transplant patients: the role of novel antimold azoles
Q49612998Pediatric Invasive Aspergillosis
Q37790947Pediatric Invasive Aspergillosis
Q46583730Pharmacodynamics of the Novel Antifungal Agent F901318 for Acute Sinopulmonary Aspergillosis Caused by Aspergillus flavus.
Q40083822Pharmacodynamics of the Orotomides against Aspergillus fumigatus: New Opportunities for Treatment of Multidrug-Resistant Fungal Disease
Q37756116Pharmacokinetic/pharmacodynamic profile of posaconazole
Q37115829Pharmacokinetics and absorption of posaconazole oral suspension under various gastric conditions in healthy volunteers
Q38193337Pharmacokinetics and pharmacodynamics of antifungals in children and their clinical implications.
Q34754956Pharmacokinetics and pharmacodynamics of posaconazole for invasive pulmonary aspergillosis: clinical implications for antifungal therapy
Q26771180Pharmacokinetics and safety of posaconazole delayed-release tablets for invasive fungal infections
Q41993016Pharmacokinetics and safety results from the Phase 3 randomized, open-label, study of intravenous posaconazole in patients at risk of invasive fungal disease.
Q35105840Pharmacokinetics and safety study of posaconazole intravenous solution administered peripherally to healthy subjects
Q55236793Pharmacokinetics of Intravenous Posaconazole in Critically Ill Patients.
Q38681635Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients
Q35941414Pharmacokinetics of different dosing strategies of oral posaconazole in patients with compromised gastrointestinal function and who are at high risk for invasive fungal infection.
Q46879963Pharmacokinetics of oral posaconazole in allogeneic hematopoietic stem cell transplant recipients with graft-versus-host disease
Q46341880Pharmacokinetics of oral posaconazole in neutropenic patients receiving chemotherapy for acute myelogenous leukemia or myelodysplastic syndrome.
Q37247780Pharmacokinetics of posaconazole administered orally or by nasogastric tube in healthy volunteers
Q38813173Pharmacokinetics of posaconazole in koalas (Phascolarctos cinereus) after intravenous and oral administration
Q35959476Pharmacology and metabolism of voriconazole and Posaconazole in the treatment of invasive aspergillosis: review of the literature
Q33798313Phase 1B study of the pharmacokinetics and safety of posaconazole intravenous solution in patients at risk for invasive fungal disease.
Q34299092Phase 1b study of new posaconazole tablet for prevention of invasive fungal infections in high-risk patients with neutropenia
Q40892430Phase 3 pharmacokinetics and safety study of a posaconazole tablet formulation in patients at risk for invasive fungal disease.
Q80066469Posaconazole
Q93480679Posaconazole (Noxafil), an Extended-Spectrum Oral Triazole Antifungal Agent
Q37203849Posaconazole Plasma Concentrations on Days Three to Five Predict Steady-State Levels
Q40337289Posaconazole Plasma Monitoring in Immunocompromised Children
Q36424973Posaconazole activity against Candida glabrata after exposure to caspofungin or amphotericin B.
Q42285675Posaconazole after previous antifungal therapy with voriconazole for therapy of invasive aspergillus disease, a retrospective analysis.
Q38899363Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole
Q44162406Posaconazole concentrations after allogeneic hematopoietic stem cell transplantation
Q46340631Posaconazole concentrations in the central nervous system
Q36018743Posaconazole exposure-response relationship: evaluating the utility of therapeutic drug monitoring
Q91916135Posaconazole for the treatment of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis
Q42572410Posaconazole in human serum: a greater pharmacodynamic effect than predicted by the non-protein-bound serum concentration
Q40827808Posaconazole in lung transplant recipients: use, tolerability, and efficacy
Q37052755Posaconazole in the management of refractory invasive fungal infections
Q35732778Posaconazole liquid suspension in solid organ transplant recipients previously treated with voriconazole
Q48118247Posaconazole oral dose and plasma levels in pediatric hematology-oncology patients
Q36505539Posaconazole pharmacodynamic target determination against wild-type and Cyp51 mutant isolates of Aspergillus fumigatus in an in vivo model of invasive pulmonary aspergillosis
Q43506893Posaconazole pharmacokinetics in a 2-year-old boy with rhino-cerebral-orbital zygomycosis
Q35647678Posaconazole plasma concentrations in juvenile patients with invasive fungal infection
Q40517272Posaconazole plasma concentrations in pediatric patients receiving antifungal prophylaxis during neutropenia.
Q38237895Posaconazole salvage treatment for invasive fungal infection
Q43056048Posaconazole salvage treatment in paediatric patients: a multicentre survey
Q34737174Posaconazole serum concentrations among cardiothoracic transplant recipients: factors impacting trough levels and correlation with clinical response to therapy
Q33798286Posaconazole tablet pharmacokinetics: lack of effect of concomitant medications altering gastric pH and gastric motility in healthy subjects.
Q92402338Posaconazole therapeutic drug monitoring in clinical practice and longitudinal analysis of the effect of routine laboratory measurements on posaconazole concentrations
Q35262607Posaconazole therapeutic drug monitoring in pediatric patients and young adults with cancer.
Q43128336Posaconazole therapeutic drug monitoring: a reference laboratory experience
Q37094649Posaconazole treatment in Korea: single-center experience over 5 years
Q37404840Posaconazole's impact on prophylaxis and treatment of invasive fungal infections: an update
Q41848545Posaconazole: A new agent for the prevention and management of severe, refractory or invasive fungal infections
Q36828159Posaconazole: a new broad-spectrum antifungal agent
Q33382991Posaconazole: a new oral antifungal agent with an expanded spectrum of activity
Q40188974Posaconazole: a next-generation triazole antifungal
Q38321383Posaconazole: a review of the gastro-resistant tablet and intravenous solution in invasive fungal infections
Q28291282Posaconazole: an oral triazole with an extended spectrum of activity
Q37901534Posaconazole: when and how? The clinician's view
Q34532546Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America
Q37327107Present situation in the treatment of invasive fungal infection
Q41688288Prevention of Invasive Aspergillosis in High-Risk Patients: Universal Versus Preemptive, Targeted Treatment
Q37344532Primary prophylaxis of invasive fungal infections in patients with hematologic malignancies. Recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology.
Q46802771Progressive fusariosis: unpredictable posaconazole bioavailability, and feasibility of recombinant interferon-gamma plus granulocyte macrophage-colony stimulating factor for refractory disseminated infection
Q35959480Prophylaxis and treatment of invasive aspergillosis with voriconazole, posaconazole and caspofungin: review of the literature
Q91876531Pros and Cons of Extrapolating Animal Data on Antifungal Pharmacodynamics to Humans
Q43754399Pulmonary and other aspergilloses in patients in the intensive care unit
Q40337647Quantitation of azoles and echinocandins in compartments of peripheral blood by liquid chromatography-tandem mass spectrometry
Q24642450Recent advances in the management of mucormycosis: from bench to bedside
Q39767419Reflections on the approach to treatment of a mycologic disaster
Q88376520Refractory Hypokalemia from Syndrome of Apparent Mineralocorticoid Excess on Low-Dose Posaconazole
Q41915726Refractory invasive aspergillosis controlled with posaconazole and pulmonary surgery in a patient with chronic granulomatous disease: case report
Q35065721Relevance of timing for determination of posaconazole plasma concentrations
Q40043031Retrospective Analysis of Posaconazole Suspension Dosing Strategies in a Pediatric Oncology Population: Single-Center Experience.
Q35860057Retrospective Comparison of Posaconazole Levels in Patients Taking the Delayed-Release Tablet versus the Oral Suspension
Q40109740Retrospective analysis of goal drug level attainment of posaconazole for invasive fungal infection prophylaxis in patients with acute myeloid leukemia pre- and post-switch to tablet formulation
Q38341595Review of the new delayed-release oral tablet and intravenous dosage forms of posaconazole
Q37055215Reviews of anti-infective agents: posaconazole: a broad-spectrum triazole antifungal agent
Q39659834Role of Aspergillus lentulus 14-α sterol demethylase (Cyp51A) in azole drug susceptibility.
Q47697145Role of New Antifungal Agents in the Treatment of Invasive Fungal Infections in Transplant Recipients: Isavuconazole and New Posaconazole Formulations.
Q33549666SREB, a GATA transcription factor that directs disparate fates in Blastomyces dermatitidis including morphogenesis and siderophore biosynthesis
Q38077591Safety of posaconazole
Q37662650Safety of triazole antifungal drugs in patients with cancer
Q42078949Selection of a surrogate agent (fluconazole or voriconazole) for initial susceptibility testing of posaconazole against Candida spp.: results from a global antifungal surveillance program.
Q37327086Sequential prescription of antifungals in invasive fungal infection: the importance of mechanism of action
Q36171677Single-dose phase I study to evaluate the pharmacokinetics of posaconazole in new tablet and capsule formulations relative to oral suspension
Q34362577Sixty-year-old man with slowly expanding nodular plaque on the thigh
Q33826421Skin concentrations and pharmacokinetics of posaconazole after oral administration
Q34108650Steady-state intrapulmonary pharmacokinetics and pharmacodynamics of posaconazole in lung transplant recipients
Q42965419Successful management of invasive pulmonary nocardiosis and aspergillosis in a patient with T-cell lymphoma: a case report.
Q34596950Switching from posaconazole suspension to tablets increases serum drug levels in leukemia patients without clinically relevant hepatotoxicity
Q40078596Synergistic drug combination effectively blocks Ebola virus infection
Q37331953The enzymatic basis of drug-drug interactions with systemic triazole antifungals.
Q90149459The potency of luliconazole against clinical and environmental Aspergillus nigri complex
Q42751535The role of second-generation antifungal triazoles for treatment of the endemic mycoses.
Q93085278Therapeutic Challenges of Non-Aspergillus Invasive Mold Infections in Immunosuppressed Patients
Q26746016Therapeutic Drug Monitoring of Posaconazole: an Update
Q37688257Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology
Q38738090Therapeutic drug monitoring for invasive mould infections and disease: pharmacokinetic and pharmacodynamic considerations
Q27009221Therapeutic drug monitoring for triazoles: A needs assessment review and recommendations from a Canadian perspective
Q38790740Therapeutic drug monitoring of anti-infective agents in critically ill patients
Q36276966Therapeutic drug monitoring of posaconazole in allogeneic hematopoietic stem cell transplantation patients who develop gastrointestinal graft-versus-host disease
Q84193187Therapeutic drug monitoring of posaconazole in hematology adults under posaconazole prophylaxis: influence of food intake
Q34108484Therapeutic drug monitoring of posaconazole in hematology patients: experience with a new high-performance liquid chromatography-based method
Q36396203Therapeutic drug monitoring of posaconazole in patients with acute myeloid leukemia or myelodysplastic syndrome
Q39041116Therapeutic drug monitoring of posaconazole oral suspension in paediatric patients younger than 13 years of age: a retrospective analysis and literature review
Q37450660Therapeutic drug monitoring of posaconazole: a monocentric study with 54 adults
Q37833074Therapeutic drug monitoring of voriconazole and posaconazole
Q38140015Therapeutic drug monitoring of voriconazole and posaconazole for invasive aspergillosis.
Q90672647Therapy of Mucormycosis
Q58765898Treatment of Aspergillosis
Q89240837Treatment of Aspergillus fumigatus infection with posaconazole delayed-release tablets
Q40323166Treatment of Disseminated Aspergillosis with Posaconazole in 10 Dogs
Q91942866Treatment of Posaconazole-Induced Peripheral Neuropathy With Methylprednisolone and Magnesium Infusions: A Case Report
Q47697132Treatment of Primary Pulmonary Aspergillosis: An Assessment of the Evidence
Q37469829Treatment of invasive fungal infections in cancer patients-updated recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO).
Q37863921Treatment strategies for invasive aspergillosis in neutropenic patients: voriconazole or liposomal amphotericin-B?
Q37964703Triazole antifungal agents in invasive fungal infections: a comparative review
Q40762430Triazole antifungals used for prophylaxis and treatment of invasive fungal disease in adult haematology patients: Trough serum concentrations in relation to outcome.
Q28553573Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model
Q34309527Ultra-performance liquid chromatography mass spectrometry and sensitive bioassay methods for quantification of posaconazole plasma concentrations after oral dosing
Q34596750Understanding variability in posaconazole exposure using an integrated population pharmacokinetic analysis.
Q43191432Update: invasive fungal infections: Diagnosis and treatment in surgical intensive care medicine
Q37785548Updated guidelines for managing fungal diseases in hematology patients
Q90623202Use of Antifungals and Outcomes Among Inpatients at Risk of Invasive Aspergillosis or Mucormycosis in the USA: A Retrospective Cohort Study
Q41457024Use of posaconazole delayed-release tablets for treatment of invasive aspergillosis
Q37810083Use of posaconazole in the treatment of invasive fungal  infections
Q90131095Using State Transition Models to Explore How the Prevalence of Subtherapeutic Posaconazole Exposures Impacts the Clinical Utility of Therapeutic Drug Monitoring for Posaconazole Tablets and Oral Suspension
Q54243380Utility of posaconazole therapeutic drug monitoring and assessment of plasma concentration threshold for effective prophylaxis of invasive fungal infections: a meta-analysis with trial sequential analysis.
Q38890514Utilization of posaconazole oral suspension or delayed-released tablet salvage treatment for invasive fungal infection
Q38073201Voriconazole serum concentrations in obese and overweight immunocompromised patients: a retrospective review
Q46826187Voriconazole therapeutic drug monitoring in patients with invasive mycoses improves efficacy and safety outcomes
Q37141697Voriconazole-induced phototoxicity masquerading as chronic graft-versus-host disease of the skin in allogeneic hematopoietic cell transplant recipients
Q40082257Voriconazole-refractory invasive aspergillosis
Q44420165What is the role of therapeutic drug monitoring in antifungal therapy?
Q42578023What should be the first-choice strategy to maximize posaconazole exposure in daily clinical practice?
Q37374949Wild-type MIC distribution and epidemiological cutoff values for Aspergillus fumigatus and three triazoles as determined by the Clinical and Laboratory Standards Institute broth microdilution methods
Q42625550Wild-type MIC distributions and epidemiological cutoff values for posaconazole and voriconazole and Candida spp. as determined by 24-hour CLSI broth microdilution
Q83392396[Antifungal therapy update: new drugs and medical uses]
Q46020723[Keratomycosis: diagnosis and therapy].
Q84149141[Pharmacokinetics and pharmacodynamics of antifungal drugs in children]