TRH-receptor-type-2-deficient mice are euthyroid and exhibit increased depression and reduced anxiety phenotypes

scientific article published on 10 December 2008

TRH-receptor-type-2-deficient mice are euthyroid and exhibit increased depression and reduced anxiety phenotypes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NPP.2008.217
P932PMC publication ID2669701
P698PubMed publication ID19078951
P5875ResearchGate publication ID23659810

P2093author name stringBojana Zupan
Miklos Toth
Bruce M Raaka
Marvin C Gershengorn
Yuhua Sun
P2860cites workMolecular cloning of a functional human thyrotropin-releasing hormone receptorQ24317016
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Cloning and characterization of a new subtype of thyrotropin-releasing hormone receptorsQ28574315
Regulator of G protein signaling 4 suppresses basal and thyrotropin releasing-hormone (TRH)-stimulated signaling by two mouse TRH receptors, TRH-R(1) and TRH-R(2)Q28594143
The rostral anterior cingulate cortex modulates the efficiency of amygdala-dependent fear learningQ30481164
Molecular cloning of a complementary deoxyribonucleic acid encoding the thyrotropin-releasing hormone receptor and regulation of its messenger ribonucleic acid in rat GH cellsQ30983369
TRH-like antidepressant peptide, pyroglutamyltyroslyprolineamide, occurs in rat brainQ31001866
Molecular cloning of bovine thyrotropin-releasing hormone receptor geneQ32102582
The role of TRH and related peptides in the mechanism of action of ECT.Q33585961
Corticotropin-releasing hormone receptor subtypes and emotionQ33795291
Thyrotropin-releasing hormone receptors -- similarities and differencesQ34532651
Assessing antidepressant activity in rodents: recent developments and future needsQ34635853
The thyrotropin-releasing hormone (TRH) hypothesis of homeostatic regulation: implications for TRH-based therapeutics.Q35073634
The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in miceQ36008239
Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia testQ36125183
Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone geneQ36598468
Functional expression and molecular characterization of the thyrotrophin-releasing hormone receptor from the rat anterior pituitary glandQ36771232
High levels of thyrotropin-releasing hormone receptors activate programmed cell death in human pancreatic precursorsQ37109216
Expression of thyrotropin-releasing hormone receptor in immortalized beta-cell lines and rat pancreasQ40550482
Expression of thyrotropin-releasing hormone (TRH) receptor subtype 1 in mouse pancreatic islets and HIT-T15, an insulin-secreting clonal beta cell lineQ40891474
Analysis of the anxiolytic-like effect of TRH and the response of amygdalar TRHergic neurons in anxiety.Q42522485
Cloning of two thyrotropin-releasing hormone receptor subtypes from a lower vertebrate (Catostomus commersoni): functional expression, gene structure, and evolutionQ43795454
Validation of a simple, ethologically relevant paradigm for assessing anxiety in miceQ44567660
Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidismQ44779450
Effects of chronic fluoxetine in animal models of anxiety and depression.Q44845253
Gender differences in the symptoms of major depression in opposite-sex dizygotic twin pairsQ44889193
Escitalopram regulates expression of TRH and TRH-like peptides in rat brain and peripheral tissuesQ46691642
Cloning and characterization of the chicken thyrotropin-releasing hormone receptorQ47777562
Cloning and characterization of a cDNA encoding a novel subtype of rat thyrotropin-releasing hormone receptorQ48007034
cAMP response element-binding protein deficiency allows for increased neurogenesis and a rapid onset of antidepressant response.Q48103045
Two isoforms of the thyrotropin-releasing hormone receptor generated by alternative splicing have indistinguishable functional propertiesQ48143265
Thyrotropin-releasing hormone (TRH) in the neuroaxis: therapeutic effects reflect physiological functions and molecular actionsQ48144631
Decreased thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus of patients with major depressionQ48186183
Circadian rhythms of TRH-like peptide levels in rat brainQ48366381
Functional classification of antidepressants based on antagonism of swim stress-induced fos-like immunoreactivity.Q48985790
Genetic inactivation of the Serotonin(1A) receptor in mice results in downregulation of major GABA(A) receptor alpha subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety.Q49084771
Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior.Q50893115
Cloning and Characterization of the Chicken Thyrotropin-Releasing Hormone ReceptorQ58853826
“Behavioural despair” in rats and mice: Strain differences and the effects of imipramineQ67016807
Nocturnal serum thyrotropin (TSH) surge and the TSH response to TSH-releasing hormone: dissociated behavior in untreated depressivesQ68353475
Pyroglutamyl-phenylalanyl-proline amide attenuates thyrotropin-releasing hormone-stimulated insulin secretion in perifused rat islets and insulin-secreting clonal beta-cell linesQ71813094
Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming testQ73257799
TRH-R2 exhibits similar binding and acute signaling but distinct regulation and anatomic distribution compared with TRH-R1Q73340522
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1601-1608
P577publication date2008-12-10
P1433published inNeuropsychopharmacologyQ2261280
P1476titleTRH-receptor-type-2-deficient mice are euthyroid and exhibit increased depression and reduced anxiety phenotypes
P478volume34

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