Genetic inactivation of the Serotonin(1A) receptor in mice results in downregulation of major GABA(A) receptor alpha subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety.

scientific article published in April 2000

Genetic inactivation of the Serotonin(1A) receptor in mice results in downregulation of major GABA(A) receptor alpha subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1523/JNEUROSCI.20-08-02758.2000
P932PMC publication ID6772213
P698PubMed publication ID10751426

P2093author name stringM Toth
C Pavlides
E Sibille
D Benke
P2860cites workIncreased anxiety of mice lacking the serotonin1A receptorQ24655613
International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor functionQ28275171
Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptorsQ28367959
Serotonin receptor 1A knockout: an animal model of anxiety-related disorderQ28592514
Structural basis of the cholinergic and serotonergic modulation of GABAergic neurons in the hippocampus.Q33682476
(-)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain.Q34306344
Serotonin receptor binding in a colony model of chronic social stressQ34312379
Quantitative RT-PCR: pitfalls and potentialQ34488305
Functional GABAA receptors on rat vagal afferent neuronesQ35025694
Activation of heteromeric G protein-gated inward rectifier K+ channels overexpressed by adenovirus gene transfer inhibits the excitability of hippocampal neuronsQ36248443
Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant miceQ36759748
5-HT1A receptor responsivity in anxiety disorders and depressionQ36882165
Neuropsychiatric disorders and the multiple human brain serotonin receptor subtypes and subsystemsQ37783098
GABAA receptor channelsQ40389943
Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.Q40417870
Antidepressant-like behavioral effects of serotonin receptor agonistsQ40746504
5-HT1A receptor agonists: recent developments and controversial issuesQ40933736
GABAergic antagonists block the inhibitory effects of serotonin in the lateral amygdala: a mechanism for modulation of sensory inputs related to fear conditioning.Q42472586
Electrophysiological assessment of the effects of antidepressant treatments on the efficacy of 5-HT neurotransmissionQ46591301
Chronic intermittent ethanol treatment in rats increases GABA(A) receptor alpha4-subunit expression: possible relevance to alcohol dependenceQ46909881
Serotonergic modulation of neurotransmission in the rat basolateral amygdalaQ48167058
Decreased benzodiazepine receptor binding in panic disorder measured by IOMAZENIL-SPECT. A preliminary reportQ48224486
Stress and antidepressant effects on hippocampal and cortical 5-HT1A and 5-HT2 receptors and transport sites for serotoninQ48265251
Comparative effects of chronic 8-OH-DPAT, gepirone and ipsapirone treatment on the sensitivity of somatodendritic 5-HT1A autoreceptorsQ48276230
Effects of diazepam, pentobarbital, phenytoin and pentylenetetrazol on hippocampal paired-pulse inhibition in vivoQ48353685
Serotonin modulation of sensory inputs to the lateral amygdala: dependency on corticosterone.Q48360085
A.E. Bennett Research Award. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depressionQ48381596
Serotonin depresses excitatory synaptic transmission and depolarization-evoked Ca2+ influx in rat basolateral amygdala via 5-HT1A receptorsQ48387281
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptorsQ48436884
GABA(A) receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroidQ48472565
Kindling-induced long-lasting changes in synaptic transmission in the basolateral amygdalaQ48542855
Hyperpolarization of serotonergic neurons by serotonin and LSD: studies in brain slices showing increased K+ conductanceQ48646559
Regional densities of benzodiazepine sites in the CNS of alcohol-naive P and NP ratsQ48650581
Animal models of chronic anxiety and "fearlessness".Q48954395
Electrophysiological effects of N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl) cyclohexane carboxamide (WAY 100635) on dorsal raphe serotonergic neurons and CA1 hippocampal pyramidal cells in vitroQ48956959
Differential mechanisms involved in the anticonflict action of benzodiazepines injected into the central amygdala and mammillary bodyQ48959018
Reduced benzodiazepine sensitivity in patients with premenstrual syndrome: a pilot study.Q51107637
Anxiogenic effects of methyl-beta-carboline-3-carboxylate in a light/dark choice situation.Q51196806
Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.Q51434685
Rapid and simple chromatographic method for the determination of diazepam and its major metabolites in human plasma and urine.Q51512539
GABAergic influences on plus-maze behaviour in mice.Q51555878
Reduced benzodiazepine sensitivity in patients with panic disorder: comparison with patients with obsessive-compulsive disorder and normal subjects.Q51559603
Single administration of 5-HT1A agonists decreases 5-HT1A presynaptic, but not postsynaptic receptor-mediated responses: relationship to antidepressant-like actionQ60054786
Reduced benzodiazepine receptor binding in panic disorders measured by iomazenil SPECTQ71368033
Dynamics of central nervous 5-HT1A-receptors under psychosocial stressQ71511531
A synthetic standard for competitive RT-PCR quantitation of 13 GABA receptor type A subunit mRNAs in rats and miceQ77750775
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectserotoninQ167934
P304page(s)2758-2765
P577publication date2000-04-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleGenetic inactivation of the Serotonin(1A) receptor in mice results in downregulation of major GABA(A) receptor alpha subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety
P478volume20

Reverse relations

cites work (P2860)
Q350715115-HT1A receptor knockout mice and mice overexpressing corticotropin-releasing hormone in models of anxiety
Q345316265-HT1A receptor knockout mouse as a genetic model of anxiety
Q318700555-HT1B receptor knockout, but not 5-HT1A receptor knockout mice, show reduced startle reactivity and footshock-induced sensitization, as measured with the acoustic startle response
Q2829756950 years of hurdles and hope in anxiolytic drug discovery
Q37361257Alpha-Ca2+/calmodulin-dependent protein kinase II contributes to the developmental programming of anxiety in serotonin receptor 1A knock-out mice
Q34117511Altered fear circuits in 5-HT(1A) receptor KO mice
Q35176167Animal models of anxiety disorders
Q43867264Anxiogenic activity of Myristica fragrans seeds
Q35534540Anxious and nonanxious mice show similar hippocampal sensory evoked oscillations under urethane anesthesia: difference in the effect of buspirone.
Q28593407Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning
Q43169237BDNF selectively regulates GABAA receptor transcription by activation of the JAK/STAT pathway
Q34571711Bombesin receptors as a novel anti-anxiety therapeutic target: BB1 receptor actions on anxiety through alterations of serotonin activity.
Q60959809Brain Vitamin E Deficiency During Development Is Associated With Increased Glutamate Levels and Anxiety in Adult Mice
Q35032878Cellular correlates of anxiety in CA1 hippocampal pyramidal cells of 5-HT1A receptor knockout mice
Q36411880Childhood trauma and personality disorder: toward a biological model
Q31514125Chronic cocaine differentially affects diazepam's anxiolytic and anticonvulsant actions. Relationship to GABA(A) receptor subunit expression
Q42436765Compartmentation of alpha 1 and alpha 2 GABA(A) receptor subunits within rat extended amygdala: implications for benzodiazepine action
Q48615603Contrasting phenotypes of C57BL/6JOlaHsd, 129S2/SvHsd and 129/SvEv mice in two exploration-based tests of anxiety-related behaviour
Q35598139Decreased GABAA receptor binding in the medullary serotonergic system in the sudden infant death syndrome
Q28307036Developmental psychopathology and neurobiology of aggression
Q43619730Differential effects of 5-HT1A receptor deletion upon basal and fluoxetine-evoked 5-HT concentrations as revealed by in vivo microdialysis
Q46585539Early postnatal stress alters the 5-HTergic modulation to emotional stress at postadolescent periods of rats
Q36777159Effect of 3α-anderostanediol and indomethacin on acquisition, consolidation and retrieval stage of spatial memory in adult male rats.
Q43813710Effects of cholecystokinin tetrapeptide (CCK(4)) and anxiolytic drugs on the electrically evoked [(3)H]5-hydroxytryptamine outflow from rat cortical slices
Q37361242Elevated prostacyclin biosynthesis in mice impacts memory and anxiety-like behavior
Q40579168GABA(A)-benzodiazepine receptor complex sensitivity in 5-HT(1A) receptor knockout mice on a 129/Sv background
Q34448259GABAergic control of critical developmental periods for anxiety- and depression-related behavior in mice
Q35187929GABAergic dysfunction in mood disorders.
Q43483807Gender-specific abnormalities in the serotonin transporter system in panic disorder
Q35104041Genetic animal models of anxiety
Q30487278Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease
Q58554121HBK-17, a 5-HT Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling
Q35854228Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors.
Q35834300Implications of genetic research on the role of the serotonin in depression: emphasis on the serotonin type 1A receptor and the serotonin transporter
Q41833242Inactivation of GIRK channels weakens the pre- and postsynaptic inhibitory activity in dorsal raphe neurons.
Q33947181Increased anxiety and synaptic plasticity in estrogen receptor beta -deficient mice.
Q48487138Increased fear response to contextual cues in mice lacking the 5-HT1A receptor.
Q34906869Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: relevance to emotionality and sex
Q37268540Intrahippocampal Injection of 3α Diol (a Testosterone Metabolite ) and Indomethacin (3α-HSD Blocker), Impair Acquisition of Spatial Learning and Memory in Adult Male Rats
Q43880331Light-potentiation of acoustic startle response (ASR) and monoamine efflux related to fearfulness in Fyn-deficient mice
Q37039183Maternal profiling of corticotropin-releasing factor receptor 2 deficient mice in association with restraint stress
Q36026076Mechanisms of action of antidepressants: from neurotransmitter systems to signaling pathways
Q34510367Molecular pathways of anxiety revealed by knockout mice
Q43728714Motor cortex excitability correlates with an anxiety-related personality trait
Q34574021Mouse anxiety: the power of knockout
Q30419666Neonatal testosterone partially organizes sex differences in stress-induced emotionality in mice
Q30498893Neurobiology of memory and anxiety: from genes to behavior
Q35195703New lessons from knockout mice: The role of serotonin during development and its possible contribution to the origins of neuropsychiatric disorders.
Q33999587Panic disorder
Q92761255Panic disorders: The role of genetics and epigenetics
Q34116530Pharmacogenetics and the serotonin system: initial studies and future directions.
Q34980499Pharmacogenetics of anxiolytic drugs.
Q33919784Progesterone withdrawal increases the alpha4 subunit of the GABA(A) receptor in male rats in association with anxiety and altered pharmacology - a comparison with female rats.
Q37600399RGS6 as a Novel Therapeutic Target in CNS Diseases and Cancer.
Q36235620Rapid response to fluoxetine in women with premenstrual dysphoric disorder
Q33927727Reduced GABAergic inhibition in the basolateral amygdala and the development of anxiety-like behaviors after mild traumatic brain injury.
Q44000320Reduced anxiety-- and depression-like behaviors in Emx1 homozygous mutant mice
Q34350194Serotonin 5-HT1A receptors as targets for agents to treat psychiatric disorders: rationale and current status of research.
Q43937540Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult
Q30475973Serotonin1A receptor deletion does not interact with maternal separation-induced increases in startle reactivity and prepulse inhibition deficits
Q35163769Somatostatin, neuronal vulnerability and behavioral emotionality
Q46598643State-dependent alterations in hippocampal oscillations in serotonin 1A receptor-deficient mice.
Q40604724Stress-induced hyperthermia in the 5-HT(1A) receptor knockout mouse is normal
Q33720433Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus
Q37159970TRH-receptor-type-2-deficient mice are euthyroid and exhibit increased depression and reduced anxiety phenotypes
Q60501981The Behavioral Genetics of Serotonin: Relevance to Anxiety and Depression
Q30417098The Role of Genetic Sex in Affect Regulation and Expression of GABA-Related Genes Across Species
Q35071483The Vogel conflict test: procedural aspects, gamma-aminobutyric acid, glutamate and monoamines
Q35584090The developmental role of serotonin: news from mouse molecular genetics
Q35202929The neurobiology and control of anxious states
Q34756886The neurobiology and neuroendocrinology of stress. Implications for post-traumatic stress disorder from a basic science perspective
Q34105817The neurobiology of stress: from serendipity to clinical relevance
Q35094630The role of hormones and hormonal treatments in premenstrual syndrome.
Q36917104The role of the serotonergic and GABA system in translational approaches in drug discovery for anxiety disorders
Q37295518The roles of sex and serotonin transporter levels in age- and stress-related emotionality in mice
Q35682947The serotonergic system and anxiety
Q44978629Variability in the benzodiazepine response of serotonin 5-HT1A receptor null mice displaying anxiety-like phenotype: evidence for genetic modifiers in the 5-HT-mediated regulation of GABA(A) receptors.