| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1051356278 |
| P356 | DOI | 10.1038/NG.1053 |
| P2888 | exact match | https://scigraph.springernature.com/pub.10.1038/ng.1053 |
| P932 | PMC publication ID | 3773908 |
| P698 | PubMed publication ID | 22286214 |
| P5875 | ResearchGate publication ID | 221785788 |
| P50 | author | Philippe Froguel | Q3379857 |
| Serge Hercberg | Q26883886 | ||
| Inês Barroso | Q28039326 | ||
| Claudia Langenberg | Q28805348 | ||
| Nabila Bouatia-Naji | Q30225478 | ||
| Felicity Payne | Q30435356 | ||
| Michel Marre | Q37631006 | ||
| Robert Sladek | Q37633854 | ||
| Loic Yengo | Q37634241 | ||
| Amélie Bonnefond | Q38232358 | ||
| Katherine Fawcett | Q56166969 | ||
| Nicholas J. Wareham | Q56936055 | ||
| Sébastien Czernichow | Q61794181 | ||
| Mark McCarthy | Q62733235 | ||
| P2093 | author name string | Ralf Jockers | |
| Ghislain Rocheleau | |||
| Guillaume Charpentier | |||
| Samy Hadjadj | |||
| Olivier Lantieri | |||
| Christian Dina | |||
| Aurélie Dechaume | |||
| Martine Vaxillaire | |||
| Beverley Balkau | |||
| Jean-Luc Guillaume | |||
| Ronan Roussel | |||
| Nathalie Clément | |||
| Emmanuel Vaillant | |||
| Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC) | |||
| P2860 | cites work | Finding the missing heritability of complex diseases | Q22122198 |
| Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis | Q24609915 | ||
| International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors | Q24623433 | ||
| Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes | Q24633002 | ||
| Variants in MTNR1B influence fasting glucose levels | Q24642630 | ||
| Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes | Q24651119 | ||
| A method and server for predicting damaging missense mutations | Q27860835 | ||
| Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer | Q28213709 | ||
| A genome-wide association study identifies novel risk loci for type 2 diabetes | Q28287727 | ||
| Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia | Q28943439 | ||
| Circadian integration of metabolism and energetics | Q29619638 | ||
| A novel adaptive method for the analysis of next-generation sequencing data to detect complex trait associations with rare variants due to gene main effects and interactions | Q33728642 | ||
| MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans | Q33869843 | ||
| Common vs. rare allele hypotheses for complex diseases | Q34038820 | ||
| A primary prevention trial using nutritional doses of antioxidant vitamins and minerals in cardiovascular diseases and cancers in a general population: the SU.VI.MAX study--design, methods, and participant characteristics. SUpplementation en VItamin | Q34067086 | ||
| Reduced expression of IFIH1 is protective for type 1 diabetes | Q34115336 | ||
| A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2. | Q34301643 | ||
| Cohort profile: the Hertfordshire cohort study. | Q34427481 | ||
| Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion | Q34897184 | ||
| A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk | Q34897205 | ||
| Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new? | Q36790172 | ||
| Prognostic value of the insertion/deletion polymorphism of the ACE gene in type 2 diabetic subjects: results from the Non-insulin-dependent Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR), Dia | Q36842087 | ||
| Ligand binding and micro-switches in 7TM receptor structures | Q37449971 | ||
| Agomelatine, a melatonin agonist with antidepressant properties | Q37598264 | ||
| New evidence for a role of melatonin in glucose regulation | Q37812859 | ||
| Deep resequencing reveals excess rare recent variants consistent with explosive population growth | Q42700588 | ||
| Standards of medical care in diabetes--2008. | Q46828447 | ||
| [An epidemiologic survey from a network of French Health Examination Centres, (D.E.S.I.R.): epidemiologic data on the insulin resistance syndrome] | Q71798022 | ||
| Undiagnosed glucose intolerance in the community: the Isle of Ely Diabetes Project | Q72146765 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | melatonin | Q180912 |
| type 2 diabetes | Q3025883 | ||
| P304 | page(s) | 297-301 | |
| P577 | publication date | 2012-01-29 | |
| P1433 | published in | Nature Genetics | Q976454 |
| P1476 | title | Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes | |
| P478 | volume | 44 |
| Q43711913 | A genome-wide search for type 2 diabetes susceptibility genes in an extended Arab family. |
| Q57399091 | A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis |
| Q57249387 | A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity |
| Q34657883 | A rare functional noncoding variant at the GWAS-implicated MIR137/MIR2682 locus might confer risk to schizophrenia and bipolar disorder |
| Q35555666 | Activation of Melatonin Signaling Promotes β-Cell Survival and Function |
| Q45184558 | Adjusted sequence kernel association test for rare variants controlling for cryptic and family relatedness. |
| Q28395600 | Administration of Melatonin and Metformin Prevents Deleterious Effects of Circadian Disruption and Obesity in Male Rats |
| Q38752732 | An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans |
| Q34409659 | An exome sequencing pipeline for identifying and genotyping common CNVs associated with disease with application to psoriasis |
| Q35909486 | Analysis of Genes Involved in Body Weight Regulation by Targeted Re-Sequencing |
| Q37182574 | Assessing association between protein truncating variants and quantitative traits |
| Q39870473 | Assessing the impact of population stratification on association studies of rare variation |
| Q34505143 | Association between the melatonin receptor 1B gene polymorphism on the risk of type 2 diabetes, impaired glucose regulation: a meta-analysis |
| Q37608362 | Association of nocturnal melatonin secretion with insulin resistance in nondiabetic young women. |
| Q40361963 | Associations between nocturnal urinary 6-sulfatoxymelatonin, obstructive sleep apnea severity and glycemic control in type 2 diabetes |
| Q64949127 | Associations of Outdoor Temperature, Bright Sunlight, and Cardiometabolic Traits in Two European Population-Based Cohorts. |
| Q91865303 | Benefits and limitations of genome-wide association studies |
| Q99574272 | Biased signaling in naturally occurring mutations of G protein-coupled receptors associated with diverse human diseases |
| Q39604108 | Block-based association tests for rare variants using Kullback-Leibler divergence |
| Q30354544 | Bridging the gap between genetic associations and molecular mechanisms for type 2 diabetes. |
| Q98463611 | CRISPR/Cas9 mediated mutation of the mtnr1a melatonin receptor gene causes rod photoreceptor degeneration in developing Xenopus tropicalis |
| Q30654065 | Calcium release channel RyR2 regulates insulin release and glucose homeostasis |
| Q41658178 | Chromosome 18q deletion syndrome with autoimmune diabetes mellitus: putative genomic loci for autoimmunity and immunodeficiency |
| Q36790442 | Chronobiology of Melatonin beyond the Feedback to the Suprachiasmatic Nucleus-Consequences to Melatonin Dysfunction |
| Q39040818 | Chronomedicine and type 2 diabetes: shining some light on melatonin |
| Q37106369 | Chronotype is independently associated with glycemic control in type 2 diabetes |
| Q92062260 | Circadian Clock and Sirtuins in Diabetic Lung: A Mechanistic Perspective |
| Q28392828 | Circadian System and Glucose Metabolism: Implications for Physiology and Disease |
| Q90371405 | Circadian clocks and insulin resistance |
| Q101237586 | Circadian rhythms and the gut microbiota: from the metabolic syndrome to cancer |
| Q38808702 | Common and rare forms of diabetes mellitus: towards a continuum of diabetes subtypes |
| Q36867614 | Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans |
| Q38816592 | Complex Genetics of Type 2 Diabetes and Effect Size: What have We Learned from Isolated Populations? |
| Q35561050 | Convergence of melatonin and serotonin (5-HT) signaling at MT2/5-HT2C receptor heteromers |
| Q64118655 | DNA Methylation of Five Core Circadian Genes Jointly Contributes to Glucose Metabolism: A Gene-Set Analysis in Monozygotic Twins |
| Q47732906 | Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go? |
| Q30588631 | Does genetic heterogeneity account for the divergent risk of type 2 diabetes in South Asian and white European populations? |
| Q28547042 | Drug repositioning for diabetes based on 'omics' data mining |
| Q39329664 | Evaluating empirical bounds on complex disease genetic architecture |
| Q35043079 | Evolutionary Diagnosis of non-synonymous variants involved in differential drug response |
| Q38436840 | Experimental and clinical aspects of melatonin and clock genes in diabetes |
| Q36264669 | Explaining additional genetic variation in complex traits |
| Q38993827 | Exploration on mechanism of a new type of melatonin receptor agonist Neu-p11 in hypoxia-reoxygenation injury of myocardial cells |
| Q61942850 | From Association to Function: MTNR1B |
| Q46040981 | G protein-coupled receptors in the spot light |
| Q92238732 | GPCRs in Autocrine and Paracrine Regulations |
| Q37529278 | Genetic architecture differences between pediatric and adult-onset inflammatory bowel diseases in the Polish population. |
| Q38883998 | Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. |
| Q34501150 | Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci |
| Q38214522 | Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond |
| Q30408743 | Genetics of hypertension: discoveries from the bench to human populations |
| Q38078821 | Genetics of type 2 diabetes and potential clinical implications |
| Q57417302 | Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes |
| Q36828628 | Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4. |
| Q37401735 | Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function |
| Q63916423 | Human Genetics of Obesity and Type 2 Diabetes Mellitus: Past, Present, and Future |
| Q35590120 | Human gastroenteropancreatic expression of melatonin and its receptors MT1 and MT2. |
| Q30234640 | Human genetics as a model for target validation: finding new therapies for diabetes |
| Q42651877 | IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants are Associated with Human Obesity Risk |
| Q35018875 | Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus |
| Q34682335 | Identification of rare causal variants in sequence-based studies: methods and applications to VPS13B, a gene involved in Cohen syndrome and autism |
| Q36930753 | Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology. |
| Q47971662 | Impact of exercise on diurnal and nocturnal markers of glycaemic variability and oxidative stress in obese individuals with type 2 diabetes or impaired glucose tolerance |
| Q24618492 | In search of low-frequency and rare variants affecting complex traits |
| Q28546709 | Increased Insulin following an Oral Glucose Load, Genetic Variation near the Melatonin Receptor MTNR1B, but No Biochemical Evidence of Endothelial Dysfunction in Young Asian Men and Women |
| Q61798394 | Increased frequency of rare missense PPP1R3B variants among Danish patients with type 2 diabetes |
| Q38044611 | Inferring causality and functional significance of human coding DNA variants |
| Q36915682 | Infrequent TRIB3 coding variants and coronary artery disease in type 2 diabetes |
| Q34211860 | Inheritance of rare functional GCKR variants and their contribution to triglyceride levels in families |
| Q89882659 | Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics |
| Q38262599 | Insights into the genetic susceptibility to type 2 diabetes from genome-wide association studies of glycaemic traits. |
| Q30462675 | Interacting epidemics? Sleep curtailment, insulin resistance, and obesity |
| Q38195883 | Interactions between sleep, circadian function, and glucose metabolism: implications for risk and severity of diabetes |
| Q40283155 | Investigation of the role of TCF4 rare sequence variants in schizophrenia |
| Q34879739 | Jumping on the Train of Personalized Medicine: A Primer for Non- Geneticist Clinicians: Part 3. Clinical Applications in the Personalized Medicine Area |
| Q24273406 | Jumping on the Train of Personalized Medicine: A Primer for Non-Geneticist Clinicians: Part 2. Fundamental Concepts in Genetic Epidemiology |
| Q93004780 | Lower nocturnal urinary 6-sulfatoxymelatonin is associated with more severe insulin resistance in patients with prediabetes |
| Q90455481 | MTNR1B genetic polymorphisms as risk factors for gestational diabetes mellitus: a case-control study in a single tertiary care center |
| Q36363471 | Maternal Melatonin Therapy Rescues Prenatal Dexamethasone and Postnatal High-Fat Diet Induced Programmed Hypertension in Male Rat Offspring |
| Q37448804 | Maternal genotype and gestational diabetes |
| Q38652238 | Mechanisms of Type 2 Diabetes Risk Loci |
| Q48913561 | Melatonin Attenuates Early Brain Injury via the Melatonin Receptor/Sirt1/NF-κB Signaling Pathway Following Subarachnoid Hemorrhage in Mice. |
| Q28397447 | Melatonin Pathway and Atenolol-Related Glucose Dysregulation: Is There a Correlation? |
| Q35908326 | Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks |
| Q92404323 | Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism |
| Q91707665 | Melatonin Target Proteins: Too Many or Not Enough? |
| Q43605073 | Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats. |
| Q36820392 | Melatonin and pancreatic islets: interrelationships between melatonin, insulin and glucagon |
| Q40869902 | Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism |
| Q90371354 | Melatonin in type 2 diabetes mellitus and obesity |
| Q40202910 | Melatonin protects bone marrow mesenchymal stem cells against iron overload-induced aberrant differentiation and senescence. |
| Q37007133 | Melatonin receptor genes in vertebrates |
| Q39434518 | Melatonin receptors: molecular pharmacology and signaling in the context of system bias. |
| Q27277216 | Melatonin secretion and the incidence of type 2 diabetes |
| Q48055247 | Melatonin signalling and type 2 diabetes risk: too little, too much or just right? |
| Q35559325 | Melatonin supplementation to treat the metabolic syndrome: a randomized controlled trial |
| Q53101536 | Melatonin transport into mitochondria. |
| Q38917542 | Melatonin uptake through glucose transporters: a new target for melatonin inhibition of cancer |
| Q38618827 | Melatonin, mitochondria, and the metabolic syndrome |
| Q92404206 | Melatonin: Countering Chaotic Time Cues |
| Q36291423 | Melatonin: an underappreciated player in retinal physiology and pathophysiology |
| Q38219242 | Methodology for the analysis of rare genetic variation in genome-wide association and re-sequencing studies of complex human traits |
| Q33669634 | Minireview: Toward the establishment of a link between melatonin and glucose homeostasis: association of melatonin MT2 receptor variants with type 2 diabetes |
| Q38058550 | Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes. |
| Q34523677 | Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants |
| Q47298942 | Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity. |
| Q64099928 | Off the Clock: From Circadian Disruption to Metabolic Disease |
| Q36600267 | On Efficient and Accurate Calculation of Significance P-Values for Sequence Kernel Association Testing of Variant Set. |
| Q36345553 | Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion |
| Q47214502 | Pathogenic Anti-Müllerian Hormone Variants in Polycystic Ovary Syndrome |
| Q28236687 | Physiological responses to food intake throughout the day |
| Q37220830 | Predicting risk of type 2 diabetes mellitus with genetic risk models on the basis of established genome-wide association markers: a systematic review |
| Q55248558 | Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment. |
| Q28118188 | Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons |
| Q37686441 | Rare coding variants and breast cancer risk: evaluation of susceptibility Loci identified in genome-wide association studies |
| Q34647928 | Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity |
| Q34583590 | Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes |
| Q36524770 | Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis |
| Q38084443 | Rare-variant genome-wide association studies: a new frontier in genetic analysis of complex traits |
| Q44085507 | Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes. |
| Q36065329 | Recent advances in understanding the genetic architecture of type 2 diabetes |
| Q26766482 | Recent progress in genetic and epigenetic research on type 2 diabetes |
| Q36872445 | Recent progress in the use of genetics to understand links between type 2 diabetes and related metabolic traits |
| Q44602104 | Reply to Rational drug repositioning by medical genetics |
| Q35978977 | Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults |
| Q37543773 | Searching for missing heritability: designing rare variant association studies |
| Q41364431 | Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study |
| Q30661200 | Secondary analysis of publicly available data reveals superoxide and oxygen radical pathways are enriched for associations between type 2 diabetes and low-frequency variants |
| Q35982039 | Sequence Kernel Association Analysis of Rare Variant Set Based on the Marginal Regression Model for Binary Traits |
| Q45981116 | Spectrum of mutations in monogenic diabetes genes identified from high-throughput DNA sequencing of 6888 individuals. |
| Q39282594 | Systematic Cell-Based Phenotyping of Missense Alleles |
| Q35538234 | Systematic cell-based phenotyping of missense alleles empowers rare variant association studies: a case for LDLR and myocardial infarction |
| Q28545832 | TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits |
| Q34375217 | Targeted exon sequencing fails to identify rare coding variants with large effect in rheumatoid arthritis |
| Q33858791 | Targeted resequencing and systematic in vivo functional testing identifies rare variants in MEIS1 as significant contributors to restless legs syndrome |
| Q64066397 | The Contribution of Low-Frequency and Rare Coding Variation to Susceptibility to Type 2 Diabetes |
| Q57924792 | The Hunt for Low-Frequency Alleles Predisposing to Type 2 Diabetes and Related Cardiovascular Risk Factors |
| Q51304606 | The Impact of Genetic Variants for Different Physiological Characterization of Type 2 Diabetes Loci on Gestational Insulin Signaling in Nondiabetic Pregnant Chinese Women. |
| Q40978989 | The Importance of Context: Uncovering Species- and Tissue-Specific Effects of Genetic Risk Variants for Type 2 Diabetes |
| Q47753224 | The case for too little melatonin signalling in increased diabetes risk |
| Q26738557 | The effect of lens aging and cataract surgery on circadian rhythm |
| Q38006632 | The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare variants |
| Q29583824 | The genetic architecture of type 2 diabetes |
| Q38061186 | The genetics of type 2 diabetes and its clinical relevance |
| Q34499691 | The pancreatic β cell: recent insights from human genetics |
| Q38146916 | The potential of novel biomarkers to improve risk prediction of type 2 diabetes |
| Q35612748 | The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease |
| Q38046779 | Tired of diabetes genetics? Circadian rhythms and diabetes: the MTNR1B story? |
| Q31029687 | Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors |
| Q39042849 | Transcriptional architecture of the mammalian circadian clock |
| Q38191133 | Type 2 diabetes and cardiovascular disease: what next? |
| Q57365327 | Type 2 diabetes susceptibility gene variants predispose to adult-onset autoimmune diabetes |
| Q45048753 | Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study |
| Q30390388 | Type 2 diabetes: genetic data sharing to advance complex disease research |
| Q34118849 | Understanding melatonin receptor pharmacology: latest insights from mouse models, and their relevance to human disease |
| Q37404821 | Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology |
| Q38868297 | Update on melatonin receptors: IUPHAR Review 20. |
| Q36374101 | What will diabetes genomes tell us? |
| Q30373501 | Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis. |
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