scholarly article | Q13442814 |
P356 | DOI | 10.1038/S41574-018-0130-1 |
P698 | PubMed publication ID | 30531911 |
P2093 | author name string | Ralf Jockers | |
Angeliki Karamitri | |||
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Inhibition of isoproterenol-induced lipolysis in rat inguinal adipocytes in vitro by physiological melatonin via a receptor-mediated mechanism | Q42509016 | ||
Melatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndrome. | Q42783953 | ||
Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort | Q43034276 | ||
Melatonin improves glucose homeostasis and endothelial vascular function in high-fat diet-fed insulin-resistant mice | Q43263787 | ||
Influence of melatonin administration on glucose tolerance and insulin sensitivity of postmenopausal women | Q43571991 | ||
Effects of short-term melatonin administration on lipoprotein metabolism in normolipidemic postmenopausal women | Q43577851 | ||
Melatonin inhibits fatty acid transport in inguinal fat pads of hepatoma 7288CTC-bearing and normal Buffalo rats via receptor-mediated signal transduction | Q43657995 | ||
Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes | Q43804684 | ||
Modulation of Blood Glucose by Melatonin: A Direct Action on Melatonin Receptors in Mouse Hepatocytes | Q43807731 | ||
Melatonin Enters the Cerebrospinal Fluid through the Pineal Recess | Q43829561 | ||
Absence of melatonin induces night-time hepatic insulin resistance and increased gluconeogenesis due to stimulation of nocturnal unfolded protein response. | Q44306507 | ||
Short-term exposure to melatonin differentially affects the functional sensitivity and trafficking of the hMT1 and hMT2 melatonin receptors | Q44327338 | ||
The daily rhythm in plasma glucagon concentrations in the rat is modulated by the biological clock and by feeding behavior | Q44493403 | ||
Blood pressure response to melatonin in type 1 diabetes | Q44813953 | ||
Blood pressure-lowering effect of melatonin in type 1 diabetes | Q44831555 | ||
Design and validation of the first cell-impermeant melatonin receptor agonist | Q45302101 | ||
Correction: Identifying and Characterizing Nodes Important to Community Structure Using the Spectrum of the Graph. | Q45828073 | ||
Loss of melatonin signalling and its impact on circadian rhythms in mouse organs regulating blood glucose | Q46046887 | ||
Association and evolutionary studies of the melatonin receptor 1B gene (MTNR1B) in the self-contained population of Sorbs from Germany | Q46048864 | ||
Melatonin improves oxidative stress parameters measured in the blood of elderly type 2 diabetic patients | Q46076685 | ||
Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS | Q46133592 | ||
MT1 melatonin receptor internalization underlies melatonin-induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulation | Q46313463 | ||
Melatonin from cerebrospinal fluid but not from blood reaches sheep cerebral tissues under physiological conditions | Q46608256 | ||
The PDZ protein mupp1 promotes Gi coupling and signaling of the Mt1 melatonin receptor | Q46672501 | ||
Antioxidative effects of melatonin administration in elderly primary essential hypertension patients | Q46684674 | ||
Melatonin treatment in peri- and postmenopausal women elevates serum high-density lipoprotein cholesterol levels without influencing total cholesterol levels | Q46734964 | ||
Depression of glucose levels and partial restoration of pancreatic beta-cell damage by melatonin in streptozotocin-induced diabetic rats | Q46845615 | ||
Prolonged melatonin administration decreases nocturnal blood pressure in women | Q46859155 | ||
Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status | Q46915158 | ||
Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie-Restricted Diet | Q47096054 | ||
Evaluating the glucose raising effect of established loci via a genetic risk score | Q47100859 | ||
Twenty-four-hour rhythmicity of circulating metabolites: effect of body mass and type 2 diabetes. | Q47124781 | ||
Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics | Q47172157 | ||
Macronutrient-specific effect of the MTNR1B genotype on lipid levels in response to 2 year weight-loss diets | Q47178612 | ||
Pharmacogenomics of GPCR Drug Targets | Q47284414 | ||
Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity. | Q47298942 | ||
International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors | Q24623433 | ||
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes | Q24633002 | ||
Variants in MTNR1B influence fasting glucose levels | Q24642630 | ||
Abnormal melatonin synthesis in autism spectrum disorders | Q24652560 | ||
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population | Q24654676 | ||
Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology | Q26825609 | ||
Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes | Q27277214 | ||
Melatonin secretion and the incidence of type 2 diabetes | Q27277216 | ||
MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective | Q28083929 | ||
Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons | Q28118188 | ||
Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations | Q28265726 | ||
Exploring the typology of night eating syndrome | Q28270545 | ||
Human phase response curves to three days of daily melatonin: 0.5 mg versus 3.0 mg | Q28382973 | ||
The cost of circadian desynchrony: Evidence, insights and open questions | Q28385845 | ||
Circadian System and Glucose Metabolism: Implications for Physiology and Disease | Q28392828 | ||
Melatonin influences insulin secretion primarily via MT1 receptors in rat insulinoma cells (INS-1) and mouse pancreatic islets | Q28574220 | ||
Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells | Q28583051 | ||
A genome-wide association study of gestational diabetes mellitus in Korean women | Q28943281 | ||
Sleep disturbances compared to traditional risk factors for diabetes development: systematic review and meta-analysis | Q30251995 | ||
Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants. | Q30355101 | ||
Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource | Q30416535 | ||
A central role for GRB10 in regulation of islet function in man. | Q31156020 | ||
Activation of MT(2) melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock | Q31715327 | ||
Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps | Q33556613 | ||
Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function | Q33556619 | ||
Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population | Q33640009 | ||
Minireview: Toward the establishment of a link between melatonin and glucose homeostasis: association of melatonin MT2 receptor variants with type 2 diabetes | Q33669634 | ||
Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI. | Q33688538 | ||
Influence of beta-blockers on melatonin release | Q33862746 | ||
MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans | Q33869843 | ||
Entrainment of free-running circadian rhythms by melatonin in blind people | Q33921061 | ||
Melatonin, energy metabolism, and obesity: a review | Q34040262 | ||
Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese | Q34064811 | ||
Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening. | Q34238369 | ||
Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. | Q37317415 | ||
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes. | Q37348520 | ||
Evaluating the transferability of 15 European-derived fasting plasma glucose SNPs in Mexican children and adolescents | Q37366881 | ||
The Effects of Ramelteon on Glucose Metabolism and Sleep Quality in Type 2 Diabetic Patients With Insomnia: A Pilot Prospective Randomized Controlled Trial | Q37381227 | ||
Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians | Q37400706 | ||
Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function | Q37401735 | ||
Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study | Q37429224 | ||
Variants in glucose- and circadian rhythm-related genes affect the response of energy expenditure to weight-loss diets: the POUNDS LOST Trial | Q37486408 | ||
Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics | Q37563863 | ||
New evidence for a role of melatonin in glucose regulation | Q37812859 | ||
Melatonin: both master clock output and internal time-giver in the circadian clocks network | Q37931490 | ||
Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes. | Q38058550 | ||
Detection of melatonin production from the intestinal epithelium using electrochemical methods. | Q38164057 | ||
Self-weighing in weight management: a systematic literature review | Q38292963 | ||
Evidence for a direct effect of melatonin on mitochondrial genome expression of Siberian hamster brown adipocytes | Q38302897 | ||
Late dinner impairs glucose tolerance in MTNR1B risk allele carriers: A randomized, cross-over study. | Q38377376 | ||
Melatonin: an ancient molecule that makes oxygen metabolically tolerable. | Q38566439 | ||
Melatonin and the pathologies of weakened or dysregulated circadian oscillators | Q38808754 | ||
Interaction between rs10830963 polymorphism in MTNR1B and lifestyle intervention on occurrence of gestational diabetes | Q38864204 | ||
Update on melatonin receptors: IUPHAR Review 20. | Q38868297 | ||
Melatonin influences somatostatin secretion from human pancreatic δ-cells via MT1 and MT2 receptors | Q38920395 | ||
A comprehensive map of molecular drug targets. | Q39026969 | ||
Chronomedicine and type 2 diabetes: shining some light on melatonin | Q39040818 | ||
Melatonin receptors: molecular pharmacology and signaling in the context of system bias. | Q39434518 | ||
Melatonin stimulates glucagon secretion in vitro and in vivo | Q39606472 | ||
Melatonin ameliorates high fat diet-induced diabetes and stimulates glycogen synthesis via a PKCzeta-Akt-GSK3beta pathway in hepatic cells | Q39789370 | ||
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men. | Q47322426 | ||
MTNR1B gene polymorphisms and susceptibility to Type 2 Diabetes: A pilot study in South Indians | Q47417047 | ||
Exposure to Night-Time Traffic Noise, Melatonin-Regulating Gene Variants and Change in Glycemia in Adults | Q47437450 | ||
New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation | Q47557441 | ||
Trends in GPCR drug discovery: new agents, targets and indications. | Q47597808 | ||
Immune-pineal axis - acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes. | Q47653834 | ||
Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go? | Q47732906 | ||
The case for too little melatonin signalling in increased diabetes risk | Q47753224 | ||
Effects of melatonin on islet neogenesis and beta cell apoptosis in streptozotocin-induced diabetic rats: an immunohistochemical study | Q47838533 | ||
Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release. | Q47851900 | ||
Meta-analysis on shift work and risks of specific obesity types | Q47916056 | ||
The hormone melatonin: Animal studies | Q47924117 | ||
The endogenous melatonin (MT) signal facilitates reentrainment of the circadian system to light-induced phase advances by acting upon MT2 receptors. | Q47924751 | ||
The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population. | Q47979951 | ||
Melatonin signalling and type 2 diabetes risk: too little, too much or just right? | Q48055247 | ||
Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder. | Q48151132 | ||
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes | Q48264068 | ||
Melatonin and the pineal gland: influence on mammalian seasonal and circadian physiology | Q48507069 | ||
Experimentally-induced diabetes reduces nocturnal pineal melatonin content in the Syrian hamster. | Q48855662 | ||
Melatonin receptors activate heteromeric G-protein coupled Kir3 channels. | Q49019216 | ||
Melatonin analogues as agonists and antagonists in the circadian system and other brain areas | Q49161911 | ||
Distribution and density of melatonin receptors in human main pancreatic islet cell types | Q49719310 | ||
Reply to Ahluwalia et al.: Contributions of melatonin receptors are tissue-dependent | Q50026628 | ||
Circadian control of metabolism and pathological consequences of clock perturbations. | Q50510604 | ||
Melatonin attenuates antipsychotic metabolic effects: an eight-week randomized, double-blind, parallel-group, placebo-controlled clinical trial | Q50654258 | ||
Melatonin protects mice against stress-induced inflammation through enhancement of M2 macrophage polarization | Q51000907 | ||
Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits | Q51351265 | ||
Association of the rs10830963 polymorphism in MTNR1B with fasting glucose levels in Chinese children and adolescents | Q51371621 | ||
Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents | Q51377986 | ||
Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men. | Q51384660 | ||
Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin | Q51493396 | ||
The Difficult Journey from Genome-wide Association Studies to Pathophysiology: The Melatonin Receptor 1B (MT2) Paradigm | Q51509541 | ||
Combined treatment with melatonin and insulin improves glycemic control, white adipose tissue metabolism and reproductive axis of diabetic male rats | Q51744888 | ||
Mitochondria: Central Organelles for Melatonin's Antioxidant and Anti-Aging Actions | Q51766339 | ||
Naughty Melatonin: How Mothers Tick Off their Fetus | Q51869795 | ||
Melatonin Receptor Signaling: Impact of Receptor Oligomerization on Receptor Function. | Q52560575 | ||
The Cells of the Islets of Langerhans | Q52657734 | ||
A circadian rhythm-related MTNR1B genetic variant modulates the effect of weight-loss diets on changes in adiposity and body composition: the POUNDS Lost trial | Q52667791 | ||
Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables | Q52675077 | ||
Reduced fat mass and increased lean mass in response to 1 year of melatonin treatment in postmenopausal women: A randomized placebo-controlled trial | Q53357194 | ||
Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome | Q54108270 | ||
Diurnal variation of oral glucose tolerance in volunteers and laboratory animals | Q54539643 | ||
Evidence for melatonin synthesis in mouse and human bone marrow cells. | Q55033929 | ||
Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment. | Q55248558 | ||
Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders | Q57093573 | ||
The melatonergic agonist and clinically active antidepressant, agomelatine, is a neutral antagonist at 5-HT2C receptors | Q62373349 | ||
Melatonin shifts human circadian rhythms according to a phase-response curve | Q34253161 | ||
Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism | Q34281205 | ||
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways | Q34355379 | ||
MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential. | Q34384945 | ||
Effects of Genetic Variants Previously Associated with Fasting Glucose and Insulin in the Diabetes Prevention Program | Q34415887 | ||
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci | Q34501150 | ||
Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans | Q34641320 | ||
Melatonin receptors: role on sleep and circadian rhythm regulation | Q34716949 | ||
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion | Q34897184 | ||
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk | Q34897205 | ||
Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children | Q35043398 | ||
Sensitization: a mechanism for melatonin action in the pars tuberalis | Q35080127 | ||
Distribution, function and physiological role of melatonin in the lower gut. | Q35404204 | ||
Activation of Melatonin Signaling Promotes β-Cell Survival and Function | Q35555666 | ||
Melatonin supplementation to treat the metabolic syndrome: a randomized controlled trial | Q35559325 | ||
Convergence of melatonin and serotonin (5-HT) signaling at MT2/5-HT2C receptor heteromers | Q35561050 | ||
Melatonin membrane receptors in peripheral tissues: distribution and functions | Q35784330 | ||
Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks | Q35908326 | ||
Deletion of GαZ Protein Protects against Diet-induced Glucose Intolerance via Expansion of β-Cell Mass | Q36016914 | ||
Melatonin Signal Transduction Pathways Require E-Box-Mediated Transcription of Per1 and Per2 to Reset the SCN Clock at Dusk | Q36065118 | ||
Association of Type 2 Diabetes Susceptibility Loci With One‐Year Weight Loss in the Look AHEAD Clinical Trial | Q36120556 | ||
Association Study with 77 SNPs Confirms the Robust Role for the rs10830963/G of MTNR1B Variant and Identifies Two Novel Associations in Gestational Diabetes Mellitus Development | Q36245625 | ||
GIRK Channels Mediate the Nonphotic Effects of Exogenous Melatonin | Q36272497 | ||
Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion | Q36345553 | ||
Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism | Q36661586 | ||
Melatonin and pancreatic islets: interrelationships between melatonin, insulin and glucagon | Q36820392 | ||
Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans | Q36867614 | ||
Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology. | Q36930753 | ||
Mitochondria Synthesize Melatonin to Ameliorate Its Function and Improve Mice Oocyte's Quality under in Vitro Conditions. | Q37050785 | ||
The genetics of gestational diabetes mellitus: evidence for relationship with type 2 diabetes mellitus | Q37139067 | ||
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes | Q37173576 | ||
G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans | Q37193733 | ||
Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response | Q37259911 | ||
P433 | issue | 2 | |
P921 | main subject | type 2 diabetes | Q3025883 |
P304 | page(s) | 105-125 | |
P577 | publication date | 2019-02-01 | |
P1433 | published in | Nature Reviews Endocrinology | Q2079257 |
P1476 | title | Melatonin in type 2 diabetes mellitus and obesity | |
P478 | volume | 15 |
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