Unregulated mitochondrial GSK3beta activity results in NADH: ubiquinone oxidoreductase deficiency

scientific article published on December 2008

Unregulated mitochondrial GSK3beta activity results in NADH: ubiquinone oxidoreductase deficiency is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/BF03033861
P932PMC publication ID2677990
P698PubMed publication ID19073440
P5875ResearchGate publication ID23654344

P50authorGautam N BijurQ124296519
P2093author name stringTaj D King
Buffie Clodfelder-Miller
Keri A Barksdale
P2860cites workCaspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3β and attenuated by lithiumQ43786473
Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activationQ44135113
Vitamin E blocks early events induced by 1-methyl-4-phenylpyridinium (MPP+) in cerebellar granule cells.Q44297193
Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtinQ45297269
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Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicityQ48160464
Hypertonic Stress Activates Glycogen Synthase Kinase 3β-mediated Apoptosis of Renal Medullary Interstitial Cells, Suppressing an NFκB-driven Cyclooxygenase-2-dependent Survival PathwayQ64377327
Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: evidence for free radical involvementQ67724128
1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particlesQ68474033
Abnormalities of the electron transport chain in idiopathic Parkinson's diseaseQ69361952
Glycogen synthase from rabbit skeletal muscle. State of phosphorylation of the seven phosphoserine residues in vivo in the presence and absence of adrenalineQ72756052
Purification of Glycogen Synthase Kinase 3 from Rabbit Skeletal Muscle.. Copurification with the Activating Factor (FA)of the (Mg-ATP) Dependent Protein PhosphataseQ72914857
Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawalQ73575616
Glycogen synthase kinase 3beta negatively regulates both DNA-binding and transcriptional activities of heat shock factor 1Q73901311
Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damageQ24534352
A molecular mechanism for the effect of lithium on developmentQ24629067
GSK3beta and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cellsQ28116897
The small leucine-rich proteoglycan biglycan modulates BMP-4-induced osteoblast differentiationQ28264432
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localizationQ28290083
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymeraseQ28302692
Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3 betaQ28345704
Different localization of tau protein kinase I/glycogen synthase kinase-3 beta from glycogen synthase kinase-3 alpha in cerebellum mitochondriaQ28574200
Chronic systemic pesticide exposure reproduces features of Parkinson's diseaseQ29614763
The glamour and gloom of glycogen synthase kinase-3Q29620533
Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell linesQ30305471
Complex I deficiency in Parkinson's disease frontal cortexQ30440448
Origin and functional consequences of the complex I defect in Parkinson's diseaseQ30469425
Scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitorsQ30732148
Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activationQ31034955
An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's diseaseQ33292773
Glycogen synthase kinase-3 beta is highly activated in nuclei and mitochondriaQ34282190
Mitochondrial fission in apoptosis, neurodegeneration and agingQ35595919
Generation of superoxide by the mitochondrial Complex I.Q36469867
Mitochondrial reactive oxygen species and Ca2+ signalingQ36499631
Human NADH:ubiquinone oxidoreductase deficiency: radical changes in mitochondrial morphology?Q36788822
Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicityQ37683630
Overexpressed alpha-synuclein regulated the nuclear factor-kappaB signal pathwayQ40090895
Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation.Q40370849
Glycogen synthase kinase 3beta (GSK3beta) mediates 6-hydroxydopamine-induced neuronal deathQ40558100
Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutantQ40990869
Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's diseaseQ41015571
Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorinQ41112236
Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithiumQ42484847
P433issue4
P921main subjectmitochondrionQ39572
P304page(s)367-382
P577publication date2008-12-01
P1433published inNeurotoxicity ResearchQ15764278
P1476titleUnregulated mitochondrial GSK3beta activity results in NADH: ubiquinone oxidoreductase deficiency
P478volume14

Reverse relations

cites work (P2860)
Q90627832A mitochondrial journey through acetaminophen hepatotoxicity
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Q26800952Resveratrol: A Focus on Several Neurodegenerative Diseases
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