Agglomerative epigenetic aberrations are a common event in human breast cancer

scientific article published on October 2008

Agglomerative epigenetic aberrations are a common event in human breast cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/0008-5472.CAN-08-1419
P932PMC publication ID2680223
P698PubMed publication ID18922938

P2093author name stringBernard W Futscher
Christina J Kim
Marc M Oshiro
Petr Novak
George S Watts
Taylor Jensen
P2860cites workBioconductor: open software development for computational biology and bioinformaticsQ21194861
Epigenetic silencing of DSC3 is a common event in human breast cancerQ21195245
A striking organization of a large family of human neural cadherin-like cell adhesion genesQ22010159
Characterization of the GAGE genes that are expressed in various human cancers and in normal testisQ22010231
Compromised HOXA5 function can limit p53 expression in human breast tumoursQ22254441
A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancersQ24317542
Global and Hox-specific roles for the MLL1 methyltransferaseQ24529562
Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometryQ24536837
High sensitivity mapping of methylated cytosinesQ24630600
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genomeQ24648552
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cellsQ24672969
BLAT—The BLAST-Like Alignment ToolQ24682492
Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sitesQ24682593
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 geneQ28145754
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locusQ28145756
Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificityQ28215031
The epigenomics of cancerQ28289975
Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early developmentQ28304098
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cellsQ29618090
Hypomethylation distinguishes genes of some human cancers from their normal counterpartsQ29619217
Altered Hox expression and segmental identity in Mll-mutant miceQ29620391
Epigenomic changes during leukemia cell differentiation: analysis of histone acetylation and cytosine methylation using CpG island microarraysQ33205674
Genomic profiling of CpG methylation and allelic specificity using quantitative high-throughput mass spectrometry: critical evaluation and improvementsQ33298863
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.Q33888431
Altered chromosomal methylation patterns accompany oncogene-induced transformation of human bronchial epithelial cells.Q34361939
Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastomaQ34453650
Epigenetic inactivation of the HOXA gene cluster in breast cancerQ34580018
Breast cancer prevention trials using retinoidsQ35572432
Abnormal regional hypermethylation in cancer cellsQ35777785
The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapyQ35847845
DNA hypomethylation is prevalent even in low-grade breast cancersQ35946741
High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancerQ36423456
Epigenetic remodeling during arsenical-induced malignant transformation.Q36838009
Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancerQ40073646
Regional copy number-independent deregulation of transcription in cancerQ40209266
Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancersQ43578083
Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells.Q43890956
p53 mutations in breast cancerQ44007369
Identification of DNA methylation markers for human breast carcinomas using the methylation-sensitive restriction fingerprinting technique.Q48052612
DNA motifs associated with aberrant CpG island methylationQ51949819
Retinoic acid and homeobox gene regulationQ52215432
DNA binding sites for putative methylation boundaries in the unmethylated region of the BRCA1 promoterQ52558910
Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band.Q53346861
Expression of BAGE, GAGE, and MAGE genes in human gastric carcinoma.Q53938536
Epigenetic inactivation of BRCA1 is associated with aberrant expression of CTCF and DNA methyltransferase (DNMT3B) in some sporadic breast tumoursQ54573965
A distribution free summarization method for Affymetrix GeneChip(R) arraysQ56880035
Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancersQ71729088
Hypomethylation of pericentromeric DNA in breast adenocarcinomasQ77132854
Epigenetic regulation of the human retinoblastoma tumor suppressor gene promoter by CTCFQ79961217
Identification of 20 genes aberrantly methylated in human breast cancersQ81629206
P433issue20
P407language of work or nameEnglishQ1860
P921main subjectbreast cancerQ128581
P304page(s)8616-8625
P577publication date2008-10-01
P1433published inCancer ResearchQ326097
P1476titleAgglomerative epigenetic aberrations are a common event in human breast cancer
P478volume68

Reverse relations

cites work (P2860)
Q34462001A novel epigenetic phenotype associated with the most aggressive pathway of bladder tumor progression
Q82891679A pyrosequencing assay for the quantitative methylation analysis of the PCDHB gene cluster, the major factor in neuroblastoma methylator phenotype
Q47356569A suite of DNA methylation markers that can detect most common human cancers.
Q38905879Aberrant expression and functions of protocadherins in human malignant tumors
Q36402756Agglomerates of aberrant DNA methylation are associated with toxicant-induced malignant transformation
Q38829665Alterations in Three-Dimensional Organization of the Cancer Genome and Epigenome.
Q36920160Antisense Transcript Long Noncoding RNA (lncRNA) HOTAIR is Transcriptionally Induced by Estradiol
Q37440422Arsenicals produce stable progressive changes in DNA methylation patterns that are linked to malignant transformation of immortalized urothelial cells
Q35832742Associations with early-life socio-economic position in adult DNA methylation
Q38179961Beyond E-cadherin: roles of other cadherin superfamily members in cancer
Q33649722Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake.
Q35136051Breast cancer methylomes establish an epigenomic foundation for metastasis
Q27314001Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats
Q34533607Cell-type specific DNA methylation patterns define human breast cellular identity
Q37622144Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease.
Q26798258Circadian disruption and breast cancer: an epigenetic link?
Q34743908Clinical potentials of methylator phenotype in stage 4 high-risk neuroblastoma: an open challenge.
Q38088475Clustered Protocadherins and Neuronal Diversity
Q91750876Clustered protocadherins methylation alterations in cancer
Q27025145Common gene pathways and families altered by DNA methylation in breast and prostate cancers
Q48215153Comparative analysis of DNA methylation patterns of equine sarcoid and healthy skin samples.
Q34680105Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity
Q96642228Contrasting DCIS and invasive breast cancer by subtype suggests basal-like DCIS as distinct lesions
Q36895363Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells
Q38041524DNA Hypomethylation and Activation of Germline-Specific Genes in Cancer
Q33862334DNA hypomethylation in cancer cells
Q83528971DNA methylation changes in murine breast adenocarcinomas allow the identification of candidate genes for human breast carcinogenesis
Q99592145DNA methylation of FKBP5 in South African women: associations with obesity and insulin resistance
Q48017834DNA methylation of extracellular matrix remodeling genes in children exposed to arsenic
Q53830978DNA methylation profile in chronic myelomonocytic leukemia associates with distinct clinical, biological and genetic features.
Q34412268DNA methylation profiles of airway epithelial cells and PBMCs from healthy, atopic and asthmatic children
Q33708624DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status
Q38261602DNA methylome profiling beyond promoters - taking an epigenetic snapshot of the breast tumor microenvironment
Q38498575Differential DNA methylation patterns define status epilepticus and epileptic tolerance.
Q51275940Disruption of the 3D cancer genome blueprint.
Q35051585Duodenal follicular lymphoma: comprehensive gene expression analysis with insights into pathogenesis
Q35953777Estrogen-induced chromatin decondensation and nuclear re-organization linked to regional epigenetic regulation in breast cancer
Q33736481Evaluation of affinity-based genome-wide DNA methylation data: effects of CpG density, amplification bias, and copy number variation
Q24611593Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines
Q30945124Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor
Q37138680Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm
Q35986705Functional test of PCDHB11, the most human-specific neuronal surface protein
Q37600904Fundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer
Q98771198Gene Co-expression Is Distance-Dependent in Breast Cancer
Q58321447Genome-wide DNA methylation analysis of neuroblastic tumors reveals clinically relevant epigenetic events and large-scale epigenomic alterations localized to telomeric regions
Q33687781Genomic distance entrained clustering and regression modelling highlights interacting genomic regions contributing to proliferation in breast cancer
Q35694382Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer
Q35032304Global methylation silencing of clustered proto-cadherin genes in cervical cancer: serving as diagnostic markers comparable to HPV
Q30666001HMCan: a method for detecting chromatin modifications in cancer samples using ChIP-seq data.
Q41854729HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells.
Q92035657Hormone therapy use and breast tissue DNA methylation: analysis of epigenome wide data from the normal breast study
Q34181789Identification of Driver and Passenger DNA Methylation in Cancer by Epigenomic Analysis
Q36759572Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells
Q24607308Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Q41134275Long range epigenetic silencing is a trans-species mechanism that results in cancer specific deregulation by overriding the chromatin domains of normal cells.
Q40492521Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways.
Q42065079Major chromosomal breakpoint intervals in breast cancer co-localize with differentially methylated regions
Q84153203Methylated promoters of genes encoding protocadherins as a new cancer biomarker family
Q27332414Promoter methylation of glucocorticoid receptor gene is associated with subclinical atherosclerosis: A monozygotic twin study
Q97644181Protocadherins at the Crossroad of Signaling Pathways
Q33687763RNA-Seq based genome-wide analysis reveals loss of inter-chromosomal regulation in breast cancer
Q36265886Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer
Q27011533Regulation of mammary epithelial cell homeostasis by lncRNAs
Q37229718Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization.
Q37772356The epigenetics of breast cancer
Q36959187Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations.
Q36126987Transcriptional regulation of the protocadherin β cluster during Her-2 protein-induced mammary tumorigenesis results from altered N-glycan branching
Q35052996Understanding the connection between epigenetic DNA methylation and nucleosome positioning from computer simulations
Q21133750miRNA gene promoters are frequent targets of aberrant DNA methylation in human breast cancer

Search more.