Pathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments.

scientific article published on 06 August 2013

Pathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/S10787-013-0183-7
P932PMC publication ID3779011
P698PubMed publication ID23918298
P5875ResearchGate publication ID255690027

P50authorMaree SmithQ24851696
Arjun MuralidharanQ39184346
Arjun MuralidharanQ85074407
P2860cites workRadioisotopes for metastatic bone painQ24235589
Bisphosphonates for advanced prostate cancerQ24244161
NSAIDS or paracetamol, alone or combined with opioids, for cancer painQ24246917
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
Src family kinases in tumor progression and metastasisQ24311656
RANK is essential for osteoclast and lymph node developmentQ24598872
The role of RANK-ligand inhibition in cancer: the story of denosumabQ24633284
Neuropeptide-induced androgen independence in prostate cancer cells: roles of nonreceptor tyrosine kinases Etk/Bmx, Src, and focal adhesion kinaseQ24746249
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008Q27860674
Integrin subunit expression by human osteoblasts and osteoclasts in situ and in cultureQ28202184
Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cellsQ28204395
Normal bone anatomy and physiologyQ28299969
Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosisQ28302443
A N-terminal PTHrP peptide fragment void of a PTH/PTHrP-receptor binding domain activates cardiac ET(A) receptorsQ28346383
Impaired nociception and pain sensation in mice lacking the capsaicin receptorQ28511370
Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulationQ28575953
Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 proteaseQ28618665
Cellular and Molecular Mechanisms of PainQ29011961
Cancer statistics, 2007Q29547293
Transforming Growth Factor-Beta in Osteolytic Breast Cancer Bone MetastasesQ30311918
Mechanisms of Osteoblastic Metastases: Role of Endothelin-1Q30311986
The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptorQ30434799
Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient miceQ36791739
Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone-refractory prostate cancer: a randomized, phase II, placebo-controlled trialQ44315403
Combined analysis of two multicenter, randomized, placebo-controlled studies of pamidronate disodium for the palliation of bone pain in men with metastatic prostate cancerQ44634009
A randomized, double-blind, dose-finding, multicenter, phase 2 study of radium chloride (Ra 223) in patients with bone metastases and castration-resistant prostate cancerQ44872720
Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancerQ44918129
Use of bisphosphonates can dramatically improve pain in advanced hormone-refractory prostate cancer patientsQ45144869
Safety and pain palliation of zoledronic acid in patients with breast cancer, prostate cancer, or multiple myeloma who previously received bisphosphonate therapyQ45161200
Effect of the cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: two double-blind, randomized, placebo-controlled phase I studies.Q46022677
An acid sensing ion channel (ASIC) localizes to small primary afferent neurons in ratsQ46152819
Nerve growth factor inhibition prevents traumatic neuroma formation in the rat.Q46168945
Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strengthQ46186977
Therapeutic concentrations of dasatinib inhibit in vitro osteoclastogenesis.Q46192344
Bone-targeted therapy: phase II study of strontium-89 in combination with alternating weekly chemohormonal therapies for patients with advanced androgen-independent prostate cancerQ46211584
Dasatinib is a potent inhibitor of tumour-associated macrophages, osteoclasts and the FMS receptor.Q46375220
Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer painQ46427425
New model for the induction of osteoblastic bone metastases in rat.Q46470070
Treatment of bone metastases and bone pain with bisphosphonatesQ46480300
Quantitative Neuropathology of a Focal Nerve Injury Causing HyperalgesiaQ46517514
Randomised study of single dose (8 Gy vs. 6 Gy) of analgesic radiotherapy plus zoledronic acid in patients with bone metastasesQ46587554
Biochemical markers for monitoring response to therapy: evidence for higher bone specificity by a novel marker compared with routine markersQ46593222
Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse modelQ46616183
Phosphorylation of sodium channel Na(v)1.8 by p38 mitogen-activated protein kinase increases current density in dorsal root ganglion neuronsQ46691815
Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing.Q46842240
Phosphorylation sites on calcium channel alpha1 and beta subunits regulate ERK-dependent modulation of neuronal N-type calcium channelsQ46889147
Relevance of a new rat model of osteoblastic metastases from prostate carcinoma for preclinical studies using zoledronic acidQ46931940
New Considerations in the Design of Clinical Trials for Bone MetastasesQ47139295
Dose-ranging study of the safety and pharmacokinetics of atrasentan in patients with refractory malignanciesQ47232994
Enlargement of the receptive field size to low intensity mechanical stimulation in the rat spinal nerve ligation model of neuropathyQ47237852
Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS.Q47249503
Behavioral and histological effects of endoneurial administration of nerve growth factor: possible implications in neuropathic painQ47611891
Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease.Q47687944
Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signalingQ47871615
A short treatment with an antibody to sclerostin can inhibit bone loss in an ongoing model of colitisQ47871677
Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivoQ47895026
Effect of the bisphosphonate risedronate on bone metastases in a rat mammary adenocarcinoma model systemQ48182805
A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancerQ48456368
Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury.Q48796677
Bone stem cellsQ49968520
Bone metastasis in prostate cancer: molecular and cellular mechanisms (Review).Q36840688
Role of the alpha v beta 3 integrin in human melanoma cell invasionQ36847392
New and emerging therapies for bone metastases in genitourinary cancersQ36866291
Cancer to bone: a fatal attractionQ36884628
Involvement of alpha(v)beta3 integrins in osteoclast functionQ36984939
The use of molecular markers of bone turnover in the management of patients with metastatic bone diseaseQ36990793
Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancerQ36999566
TGF-beta and BMP7 interactions in tumour progression and bone metastasisQ37002892
Endothelin receptor antagonists in cancer therapyQ37024077
The bone microenvironment in metastasis; what is special about bone?Q37028803
Current trials using bone-targeting agents in prostate cancerQ37095852
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolismQ37108966
Mechanisms of bone metastasis in prostate cancer: clinical implicationsQ37159910
Glial-cytokine-neuronal interactions underlying the mechanisms of persistent painQ37177577
Central neuronal mechanisms in cancer-induced bone pain.Q37228288
Wnt signaling and prostate cancerQ37233002
Tumor-evoked hyperalgesia and sensitization of nociceptive dorsal horn neurons in a murine model of cancer painQ37239670
Dasatinib inhibits the growth of prostate cancer in bone and provides additional protection from osteolysisQ37287442
Recent evidence for activity-dependent initiation of sympathetic sprouting and neuropathic pain.Q37310902
Profiling of dynamically changed gene expression in dorsal root ganglia post peripheral nerve injury and a critical role of injury-induced glial fibrillary acidic protein in maintenance of pain behaviors [corrected].Q37345895
Central sensitization: a generator of pain hypersensitivity by central neural plasticityQ37361185
Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2.Q37367672
The molecular mechanism behind bone remodelling: a reviewQ37423147
Dasatinib combined with docetaxel for castration-resistant prostate cancer: results from a phase 1-2 studyQ37502039
The critical role of the bone microenvironment in cancer metastasesQ37555284
Src kinases as therapeutic targets for cancerQ37604891
Mechanisms of breast cancer bone metastasisQ37652640
SRC kinase inhibition: targeting bone metastases and tumor growth in prostate and breast cancerQ37656613
Pathogenesis of osteoblastic bone metastases from prostate cancerQ37682761
The CXCR4/SDF-1 chemokine axis: a potential therapeutic target for bone metastases?Q37694721
Treatment of painful bone metastasesQ37710370
The role of glia and the immune system in the development and maintenance of neuropathic painQ37729355
Bone-marker levels in patients with prostate cancer: potential correlations with outcomesQ37758181
Dysregulation of developmental pathways in bone metastasisQ37772654
Treatment with a sclerostin antibody increases cancellous bone formation and bone mass regardless of marrow composition in adult female rats.Q50574453
Peripheral nerve injury alters excitatory synaptic transmission in lamina II of the rat dorsal horn.Q51306058
Differential patterns of bone turnover in relation to bone pain and disease extent in bone in cancer patients with skeletal metastases.Q51561993
A study of early ongoing activity in dorsal horn units following sciatic nerve constrictionQ51617222
Painful bone metastases: a prospective observational cohort study.Q52857023
International patterns of practice in palliative radiotherapy for painful bone metastases: evidence-based practice?Q53194165
Strontium(89) chloride versus palliative local field radiotherapy in patients with hormonal escaped prostate cancer: a phase III study of the European Organisation for Research and Treatment of Cancer, Genitourinary Group.Q53914259
Phase I dose-escalation study of the safety and pharmacokinetics of atrasentan: an endothelin receptor antagonist for refractory prostate cancer.Q53921000
Odanacatib in the treatment of postmenopausal women with low bone mineral density: Three-year continued therapy and resolution of effectQ58970743
Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to boneQ60504419
Intravenous Injection of Leconotide, an Omega Conotoxin: Synergistic Antihyperalgesic Effects with Morphine in a Rat Model of Bone Cancer PainQ60605623
Sclerostin antibody treatment enhances metaphyseal bone healing in ratsQ63248242
Macrophage colony stimulating factor (M-CSF) is essential for osteoclast formation in vitroQ70175220
An electrophysiological study of dorsal horn neurons in the spinal cord of rats with an experimental peripheral neuropathyQ70469587
Poststimulus afterdischarges of spinal WDR and NS units in rats with chronic nerve constrictionQ71952385
Efficacy and safety of nonsteroidal antiinflammatory drugs for cancer pain: a meta-analysisQ72880158
Endothelin-1 is a potent regulator of human bone cell metabolism in vitroQ73166864
Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer painQ73263697
Functional reorganization of sensory pathways in the rat spinal dorsal horn following peripheral nerve injuryQ73703226
The osteoclast-associated protease cathepsin K is expressed in human breast carcinomaQ73931802
Monitoring metastatic behavior of human tumor cells in mice with species-specific polymerase chain reaction: elevated expression of angiogenesis and bone resorption stimulators by breast cancer in bone metastasesQ73977301
Nerve growth factor modulates the activation status and fast axonal transport of ERK 1/2 in adult nociceptive neuronesQ74419227
Tumor-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancerQ77602071
Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapyQ30437441
Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formationQ30441987
Skeletal metastases: decreasing tumor burden by targeting the bone microenvironmentQ30444637
Molecular biology of bone metastasisQ30444749
Molecular mechanisms and treatment of bone metastasisQ30445717
Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligandQ30670375
Radiotherapy for the palliation of painful bone metastases.Q30868320
A multiinstitutional, concurrent chemoradiation trial of strontium-89, estramustine, and vinblastine for hormone refractory prostate carcinoma involving boneQ31045889
Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 productionQ31805202
Bisphosphonates for the relief of pain secondary to bone metastases.Q32139406
Organization of a unique net-like meshwork of CGRP+ sensory fibers in the mouse periosteum: implications for the generation and maintenance of bone fracture painQ33303298
A Phase I/II study of strontium-89 combined with gemcitabine in the treatment of patients with androgen independent prostate carcinoma and bone metastasesQ33348291
A comparative study of 188Re-HEDP, 186Re-HEDP, 153Sm-EDTMP and 89Sr in the treatment of painful skeletal metastasesQ33375859
A phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket- directed SRC inhibitor, in patients with advanced malignanciesQ33405571
Breakthrough pain in cancer patients: pathophysiology and treatmentQ33585770
The pharmacology of bisphosphonates and new insights into their mechanisms of actionQ33746152
Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neuronsQ33907117
Mechanism of cancer painQ33953901
Bone health and prostate cancerQ33977536
Sclerostin: current knowledge and future perspectivesQ33992612
Management of painful bone metastasesQ34004523
Anti-endothelin drugs in solid tumorsQ34021011
Pain affect encoded in human anterior cingulate but not somatosensory cortex.Q34065017
Cellular and neurochemical remodeling of the spinal cord in bone cancer painQ34094107
CXCL12 (SDF-1)/CXCR4 pathway in cancerQ34116260
Bone cancer pain.Q34120101
A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinomaQ34152748
Preliminary study of the specific endothelin a receptor antagonist zibotentan in combination with docetaxel in patients with metastatic castration-resistant prostate cancerQ34161050
Metastatic bone disease: role of transcription factors and future targetsQ34217531
A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate cancerQ34322294
Biology of osteoclast activation in cancerQ34324255
Malignant bone pain: pathophysiology and treatmentQ34418896
A phase I study of zibotentan (ZD4054) in patients with metastatic, castrate-resistant prostate cancerQ34433349
Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo.Q40472142
The role of thrombin in tumor cell metastasisQ40472721
Effects of physiological concentrations of steroid hormones and interleukin-11 on basal and stimulated production of interleukin-8 by human osteoblast-like cells with different functional profilesQ40581403
Interleukin-8 confers androgen-independent growth and migration of LNCaP: differential effects of tyrosine kinases Src and FAK.Q40591646
Alterations in dorsal horn neurones in a rat model of cancer-induced bone painQ40610103
Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells.Q40742643
Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblastsQ41182590
Cancer therapy using bone-seeking isotopes.Q41205760
Characterization of a rat model of metastatic prostate cancer bone painQ41244868
Interleukin 1beta facilitates bone cancer pain in rats by enhancing NMDA receptor NR-1 subunit phosphorylation.Q41257707
Identification of endothelin–1 in the pathophysiology of metastatic adenocarcinoma of the prostateQ41304383
Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligationQ41441819
Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo.Q41469995
Osteoclasts express high levels of pp60c-src in association with intracellular membranesQ41774224
Differential ATF3 expression in dorsal root ganglion neurons reveals the profile of primary afferents engaged by diverse noxious chemical stimuliQ41822232
Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind studyQ41904942
Use of bisphosphonates in advanced prostate cancer: Current statusQ41986952
Differential expression of extracellular matrix molecules and the alpha 6-integrins in the normal and neoplastic prostate.Q42068925
p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesiaQ42526677
Pharmacological characterization of A-127722: an orally active and highly potent ETA-selective receptor antagonist.Q42556448
The cathepsin K inhibitor odanacatib suppresses bone resorption in women with breast cancer and established bone metastases: results of a 4-week, double-blind, randomized, controlled trialQ42781348
Evaluation of the safety, pharmacokinetics and treatment effects of an alpha(nu)beta(3) integrin inhibitor on bone turnover and disease activity in men with hormone-refractory prostate cancer and bone metastasesQ43096538
Combined use of zoledronic acid and 153Sm-EDTMP in hormone-refractory prostate cancer patients with bone metastasesQ43146234
Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorptionQ43195946
Odanacatib, a cathepsin-K inhibitor for osteoporosis: a two-year study in postmenopausal women with low bone densityQ43252754
Effects of the Src kinase inhibitor saracatinib (AZD0530) on bone turnover in healthy men: a randomized, double-blind, placebo-controlled, multiple-ascending-dose phase I trial.Q43272514
Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancerQ43690869
Pamidronate decreases tumor-induced osteoclastogenesis in osteopetrotic miceQ43716624
A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastasesQ44291815
Cathepsin K mRNA and protein expression in prostate cancer progressionQ44303172
Bisphosphonates' antitumor activity: an unravelled side of a multifaceted drug class.Q37775202
Clinical development of anti-RANKL therapies for treatment and prevention of bone metastasisQ37800534
Sclerostin monoclonal antibody therapy with AMG 785: a potential treatment for osteoporosisQ37813135
Steps in prostate cancer progression that lead to bone metastasisQ37848782
A randomized, dose-response, multicenter phase II study of radium-223 chloride for the palliation of painful bone metastases in patients with castration-resistant prostate cancer.Q37985149
Novel therapies in benign and malignant bone diseases.Q37991789
Bone-targeting radiopharmaceuticals for the treatment of prostate cancer with bone metastasesQ38004275
Downregulation of osteopontin and bone sialoprotein II is related to reduced colony formation and metastasis formation of MDA-MB-231 human breast cancer cellsQ38347522
Optimization and characterization of a rat model of prostate cancer-induced bone pain using behavioral, pharmacological, radiological, histological and immunohistochemical methods.Q39180043
Time course of pain relief in patients treated with radiotherapy for cancer pain: a prospective studyQ39293967
89Sr versus 153Sm-EDTMP: comparison of treatment efficacy of painful bone metastases in prostate and breast carcinomaQ39339046
Prospective evaluation of samarium-153-EDTMP radionuclide treatment for bone metastases in patients with hormone-refractory prostate cancerQ39341850
Samarium-153-Lexidronam complex for treatment of painful bone metastases in hormone-refractory prostate cancerQ39380785
Role of strontium-89 as adjuvant to palliative external beam radiotherapy is questionable: results of a double-blind randomized studyQ39392355
The PLACORHEN study: a double-blind, placebo-controlled, randomized radionuclide study with (186)Re-etidronate in hormone-resistant prostate cancer patients with painful bone metastases. Placebo Controlled Rhenium StudyQ39403474
Atrasentan, an endothelin-receptor antagonist for refractory adenocarcinomas: safety and pharmacokineticsQ39408230
Effects of low-dose cisplatin on 89Sr therapy for painful bone metastases from prostate cancer: a randomized clinical trial.Q39411167
Palliation of pain associated with metastatic bone cancer using samarium-153 lexidronam: a double-blind placebo-controlled clinical trialQ39449208
A dose-controlled study of 153Sm-ethylenediaminetetramethylenephosphonate (EDTMP) in the treatment of patients with painful bone metastases.Q39452323
A comparison of the palliative effects of strontium-89 and external beam radiotherapy in metastatic prostate cancerQ39485688
Clinical experience with strontium-89 in prostatic and breast cancer patientsQ39493290
Results of a randomized phase-III trial to evaluate the efficacy of strontium-89 adjuvant to local field external beam irradiation in the management of endocrine resistant metastatic prostate cancer.Q39494429
A prospective, randomised double-blind crossover study to examine the efficacy of strontium-89 in pain palliation in patients with advanced prostate cancer metastatic to boneQ39513078
The palliation of symptomatic osseous metastases: final results of the Study by the Radiation Therapy Oncology GroupQ39562742
Prevalent expression of the immunostimulatory MHC class I chain-related molecule is counteracted by shedding in prostate cancerQ39676621
ERK1/2 mitogen-activated protein kinase phosphorylates sodium channel Na(v)1.7 and alters its gating propertiesQ39744096
Dasatinib inhibits both osteoclast activation and prostate cancer PC-3-cell-induced osteoclast formationQ39783688
Activation of MCP-1/CCR2 axis promotes prostate cancer growth in boneQ39918594
Differential activation of spinal cord glial cells in murine models of neuropathic and cancer painQ39979267
Src kinase potentiates androgen receptor transactivation function and invasion of androgen-independent prostate cancer C4-2 cellsQ40020055
A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone.Q40360908
Serendipity in anticancer drug discoveryQ40368701
Roles of osteonectin in the migration of breast cancer cells into boneQ40371223
Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesionsQ40380761
Human osteocalcin and bone sialoprotein mediating osteomimicry of prostate cancer cells: role of cAMP-dependent protein kinase A signaling pathwayQ40444119
Bone stem cellsQ77808012
Simultaneous reduction in cancer pain, bone destruction, and tumor growth by selective inhibition of cyclooxygenase-2Q78710366
Suppression of prostate cancer induced bone remodeling by the endothelin receptor A antagonist atrasentanQ78954066
Changes in response properties of nociceptive dorsal horn neurons in a murine model of cancer painQ79717702
Superficial dorsal horn neuronal responses and the emergence of behavioural hyperalgesia in a rat model of cancer-induced bone painQ79920194
Effects of Vitaxin, a novel therapeutic in trial for metastatic bone tumors, on osteoclast functions in vitroQ80052261
The pharmacologic management of cancer painQ80238545
Osteoprotegerin (OPG) produced by bone marrow stromal cells protects breast cancer cells from TRAIL-induced apoptosisQ81067700
Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibiaQ81195598
Sympathetic sprouting and changes in nociceptive sensory innervation in the glabrous skin of the rat hind paw following partial peripheral nerve injuryQ82679670
Delayed reinnervation by nonpeptidergic nociceptive afferents of the glabrous skin of the rat hindpaw in a neuropathic pain modelQ82682131
[Establishment of bone metastasis model of prostate cancer in nude mice by intratibia injection of human prostate cancer cell line Du145]Q82738956
Safety and efficacy of the specific endothelin-A receptor antagonist ZD4054 in patients with hormone-resistant prostate cancer and bone metastases who were pain free or mildly symptomatic: a double-blind, placebo-controlled, randomised, phase 2 triaQ82766552
Sclerostin antibody treatment enhances bone strength but does not prevent growth retardation in young mice treated with dexamethasoneQ83836228
Bone continuum of cancerQ84358136
Growth regulatory factors and boneQ34435604
Integrins and bone metastasis: integrating tumor cell and stromal cell interactionsQ34441622
Treatment and prevention of bone complications from prostate cancerQ34441944
Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cellsQ34460378
Bone cancer induces a unique central sensitization through synaptic changes in a wide area of the spinal cordQ34489274
Radiopharmaceutical therapy for palliation of bone pain from osseous metastases.Q34549971
Clinical features of metastatic bone disease and risk of skeletal morbidityQ34576366
Phase II study of dasatinib in patients with metastatic castration-resistant prostate cancerQ34613941
Current aproach to cancer pain management: Availability and implications of different treatment options.Q34779398
Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancerQ34898980
Integrin targeted therapeuticsQ34912684
Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530.Q34959208
Mechanisms of osteolytic bone metastases in breast carcinomaQ35053951
Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases.Q35062543
Antagonism of nerve growth factor-TrkA signaling and the relief of painQ35064559
Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer painQ35421746
Palliation of Metastatic Bone Pain: Single Fraction versus Multifraction Radiotherapy – A Systematic Review of Randomised TrialsQ35549679
A phase II trial of the Src-kinase inhibitor AZD0530 in patients with advanced castration-resistant prostate cancer: a California Cancer Consortium studyQ35576853
IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiologyQ35640443
Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasisQ35679829
Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells.Q35688200
Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases.Q35753328
Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy - a systematic review of the randomised trials.Q35754868
The significance of cancer cell expression of the chemokine receptor CXCR4.Q35832343
Clinical development of anti-RANKL therapyQ35901092
Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone painQ35984168
Once-daily dasatinib: expansion of phase II study evaluating safety and efficacy of dasatinib in patients with metastatic castration-resistant prostate cancerQ36087899
Dissociation of spinal microglia morphological activation and peripheral inflammation in inflammatory pain modelsQ36380148
Clinical applications of 188Re-labelled radiopharmaceuticals for radionuclide therapyQ36396723
Wnt signaling and osteoblastogenesisQ36589094
Cancer pain and its impact on diagnosis, survival and quality of lifeQ36599929
A "class action" against the microenvironment: do cancer cells cooperate in metastasis?Q36649455
Targeted and systemic radiotherapy in the treatment of bone metastasisQ36679453
The role of tumor microenvironment in prostate cancer bone metastasisQ36771551
P275copyright licenseCreative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P433issue5
P921main subjectprostate cancerQ181257
boneQ265868
pain managementQ621261
bone neoplasmQ1328805
nociceptive painQ2533455
prostate neoplasmQ56014511
P304page(s)339-363
P577publication date2013-08-06
P1433published inInflammopharmacologyQ15751310
P1476titlePathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments
P478volume21