A hypothesis accounting for the paradoxical expression of the D gene segment in the BCR and the TCR.

scientific article published on July 2008

A hypothesis accounting for the paradoxical expression of the D gene segment in the BCR and the TCR. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/EJI.200738089
P932PMC publication ID2682786
P698PubMed publication ID18546143
P5875ResearchGate publication ID5309347

P2093author name stringMelvin Cohn
P2860cites workNothing in Biology Makes Sense except in the Light of EvolutionQ22064567
The Tritope Model for restrictive recognition of antigen by T-cells II. Implications for ontogeny, evolution and physiologyQ28756528
The standard model of T-cell receptor function: a critical reassessmentQ33650391
An in depth analysis of the concept of "polyspecificity" assumed to characterize TCR/BCR recognitionQ33944138
Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation.Q34480372
Haplotype exclusion: the solution to a problem in natural selectionQ34772057
Tritope model of restrictive recognition by the TCR.Q35077151
Some thoughts on the response to antigens that are effector T-helper independent ('thymus independence')Q35167130
Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody productionQ35540125
The evolutionary and structural 'logic' of antigen receptor diversityQ35937393
Degeneracy, mimicry and crossreactivity in immune recognitionQ35988442
The Tritope Model for restrictive recognition of antigen by T-cells I. What assumptions about structure are needed to explain function?Q36160213
What are the commonalities governing the behavior of humoral immune recognitive repertoires?Q36247965
On a regulatory gene controlling the expression of the murine lambda1 light chainQ36342047
On a key postulate of T-cell receptor restrictive function: the V-gene loci act as a single pool encoding recognition of the polymorphic alleles of the species major histocompatibility complexQ36711567
Crossing the SJL lambda locus into kappa-knockout mice reveals a dysfunction of the lambda 1-containing immunoglobulin receptor in B cell differentiationQ37628799
The protecton: the unit of humoral immunity selected by evolutionQ37949412
Diversity 1990.Q37949426
The E-T (elephant-tadpole) paradox necessitates the concept of a unit of B-cell function: the protectionQ38705452
Bursectomy in ovo blocks the generation of immunoglobulin diversityQ39515193
The immune system: a weapon of mass destruction invented by evolution to even the odds during the war of the DNAsQ40638252
Recognition of a specific self-peptide: self-MHC class II complex is critical for positive selection of thymocytes expressing the D10 TCR.Q40681845
A theory of the ontogeny of the chicken humoral immune system: the consequences of diversification by gene hyperconversion and its extension to rabbitQ40811965
On the Genetic Dissection of a Specific Humoral Immune Response to (1,3) DextranQ41292460
Diversity in the CDR3 region of V(H) is sufficient for most antibody specificitiesQ41753346
Regulation of the antibody repertoire through control of HCDR3 diversity.Q41961202
A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signalingQ43899250
Porcine reproductive and respiratory syndrome virus subverts repertoire development by proliferation of germline-encoded B cells of all isotypes bearing hydrophobic heavy chain CDR3.Q45397373
Ligand recognition by alpha beta T cell receptorsQ46222293
A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune functionQ46792429
D-J joining and D-J proteins in B cells and T cellsQ47688665
The chicken D locus and its contribution to the immunoglobulin heavy chain repertoireQ48201720
A hyperconversion mechanism generates the chicken light chain preimmune repertoireQ48349399
A single rearrangement event generates most of the chicken immunoglobulin light chain diversityQ48381680
Sequences of immunoglobulin lambda 1 genes in a lambda 1 defective mouse strainQ48403926
Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genesQ48409965
An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH.Q48413837
T cell development in TCR-alpha beta transgenic mice. Analysis using V(D)J recombination substrates.Q52208354
Positive and negative selection of an antigen receptor on T cells in transgenic mice.Q52249517
A strong propensity toward loop formation characterizes the expressed reading frames of the D segments at the Ig H and T cell receptor loci.Q52862325
DH reading frame bias: evolutionary selection, antigen selection or both? Evolutionary selection.Q52862882
TCR alpha-chain usage can determine antigen-selected TCR beta-chain repertoire diversity.Q52891426
Somatic hyperconversion diversifies the single Vh gene of the chicken with a high incidence in the D regionQ69235085
Has immunoglobulin come to a sticky end?Q70140185
Immune capacity of the chicken bursectomized at 60 hr of incubation; production of the immunoglobulins and specific antibodiesQ72673082
A few comments about the Cohn and Langman theory of the ontogeny of the chicken humoral immune systemQ72761222
D is for different-differences between H and L chain rearrangementQ74569859
Antibody repertoire development in fetal and neonatal piglets: XIX. Undiversified B cells with hydrophobic HCDR3s preferentially proliferate in the porcine reproductive and respiratory syndromeQ80257367
Reading of D genes in variable frames as a source of antibody diversityQ85701216
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)1779-1787
P577publication date2008-07-01
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleA hypothesis accounting for the paradoxical expression of the D gene segment in the BCR and the TCR.
P478volume38

Reverse relations

cites work (P2860)
Q30652074Challenging the Tritope Model of T cell receptor structure-function relationships with classical data on 'super' and 'allo-MHC' antigens
Q37776272Genetic control of DH reading frame and its effect on B-cell development and antigen-specifc antibody production
Q34899954On the logic of restrictive recognition of peptide by the T-cell antigen receptor
Q35747546Partial versus productive immunoglobulin heavy locus rearrangements in chronic lymphocytic leukemia: implications for B-cell receptor stereotypy
Q37186530Preferential use of DH reading frame 2 alters B cell development and antigen-specific antibody production
Q37186575Regulation of repertoire development through genetic control of DH reading frame preference
Q82282859Ten experiments that would make a difference in understanding immune mechanisms
Q36822711The link between antibodies to OxLDL and natural protection against pneumococci depends on D(H) gene conservation.
Q84926012What is so special about thinking; after all, we all do it!

Search more.