Nephron Progenitor But Not Stromal Progenitor Cells Give Rise to Wilms Tumors in Mouse Models with β-Catenin Activation or Wt1 Ablation and Igf2 Upregulation

scientific article published on February 2016

Nephron Progenitor But Not Stromal Progenitor Cells Give Rise to Wilms Tumors in Mouse Models with β-Catenin Activation or Wt1 Ablation and Igf2 Upregulation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NEO.2015.12.001
P932PMC publication ID5005262
P698PubMed publication ID26936393
P5875ResearchGate publication ID298820852

P50authorE. Cristy RuteshouserQ64848353
Qianghua HuQ104615614
Vicki HuffQ59617066
P2093author name stringM John Hicks
Sharada Mokkapati
Le Huang
P2860cites workIntestinal polyposis in mice with a dominant stable mutation of the beta-catenin geneQ24529898
Disruption of imprinting caused by deletion of the H19 gene region in miceQ28287765
Homeobox genes and connective tissue patterningQ28300079
WT-1 is required for early kidney developmentQ28512266
Glycogen synthase kinase-3 inactivation and stabilization of beta-catenin induce nephron differentiation in isolated mouse and rat kidney mesenchymesQ28584354
Nephric lineage specification by Pax2 and Pax8Q28585002
Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidneyQ28586205
Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney developmentQ28592487
Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesisQ28593339
Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidneyQ28594297
Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networksQ28594605
A robust and high-throughput Cre reporting and characterization system for the whole mouse brainQ29616609
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouseQ29620355
Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosisQ33556248
Frequent association of beta-catenin and WT1 mutations in Wilms tumors.Q33927092
Single cell dissection of early kidney development: multilineage primingQ34341652
Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylationQ34428960
Identification of a multipotent self-renewing stromal progenitor population during mammalian kidney organogenesisQ34469453
The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testisQ35033140
Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablationQ35279994
β-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumorsQ35679310
Clinically relevant subsets identified by gene expression patterns support a revised ontogenic model of Wilms tumor: a Children's Oncology Group StudyQ36200428
Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.Q36709112
Role for compartmentalization in nephron progenitor differentiationQ36712738
Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia.Q37235452
High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor populationQ37356678
β-catenin activation in a novel liver progenitor cell type is sufficient to cause hepatocellular carcinoma and hepatoblastomaQ38993024
Sequential WT1 and CTNNB1 mutations and alterations of beta-catenin localisation in intralobar nephrogenic rests and associated Wilms tumours: two case studiesQ41809711
Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis.Q48038317
Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors.Q50601697
P433issue2
P304page(s)71-81
P577publication date2016-02-01
P1433published inNeoplasiaQ2962042
P1476titleNephron Progenitor But Not Stromal Progenitor Cells Give Rise to Wilms Tumors in Mouse Models with β-Catenin Activation or Wt1 Ablation and Igf2 Upregulation
P478volume18

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cites work (P2860)
Q89859445Choosing The Right Animal Model for Renal Cancer Research
Q47280626Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number
Q89295025Loss of Dis3l2 partially phenocopies Perlman syndrome in mice and results in up-regulation of Igf2 in nephron progenitor cells
Q64970878Mutations in microRNA processing genes in Wilms tumors derepress the IGF2 regulator PLAG1.
Q90697631Overgrowth syndromes and pediatric cancers: how many roads lead to IGF2?
Q47110433Pharmacologic Inhibition of β-Catenin With Pyrvinium Inhibits Murine and Human Models of Wilms Tumor
Q64236688Platforms of in vivo genome editing with inducible Cas9 for advanced cancer modeling
Q55318193Wilms' Tumor Protein 1 and Enzymatic Oxidation of 5-Methylcytosine in Brain Tumors: Potential Perspectives.
Q47948619Wilms' tumour 1 (WT1) in development, homeostasis and disease.

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