Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice

scientific article published on June 2009

Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1011120188
P356DOI10.1186/1465-9921-10-43
P932PMC publication ID2694181
P698PubMed publication ID19486528
P5875ResearchGate publication ID26257318

P50authorRichard FlavellQ2149481
Lena AlexopoulouQ40466811
Lynne MurrayQ61905429
P2093author name stringRobert T Sarisky
Peter J Bugelski
Anuk M Das
Devon D Egenolf
Don E Griswold
Holly A Raymond
Jonathan Seideman
Karen A Smalley
Lani R San Mateo
M Lamine Mbow
Nicole C Stowell
Paul A Marsters
Rachel A Bunting
Roberta J Lamb
P2860cites workToll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infectionQ24633526
Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory responseQ24812201
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responsesQ27860685
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3Q27860854
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathwayQ28592087
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signalingQ28646137
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirusQ29615029
Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumoniaQ33247462
Toll-like receptor 3 is induced by and mediates antiviral activity against rhinovirus infection of human bronchial epithelial cellsQ33984176
mRNA is an endogenous ligand for Toll-like receptor 3.Q34290592
Activation of airway epithelial cells by toll-like receptor agonistsQ34326362
Chemokines and their receptors in asthma and chronic obstructive pulmonary diseaseQ35062711
Enhanced virulence, airway inflammation and impaired lung function induced by respiratory syncytial virus deficient in secreted G proteinQ35536713
Microbial recognition by Toll-like receptorsQ35699854
Airway mucus hypersecretion in asthma: an undervalued pathology?Q35771840
Heterogeneity of TLR-induced responses in dendritic cells: from innate to adaptive immunityQ35916604
Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cellsQ40163008
Synthetic double-stranded RNA induces multiple genes related to inflammation through Toll-like receptor 3 depending on NF-kappaB and/or IRF-3 in airway epithelial cellsQ40243516
Natural and experimental rhinovirus infections of the lower respiratory tractQ40408344
Double-stranded RNA activates RANTES gene transcription through co-operation of nuclear factor-kappaB and interferon regulatory factors in human airway epithelial cellsQ40555886
Double-stranded RNA induces the synthesis of specific chemokines by bronchial epithelial cellsQ40668784
The double-stranded RNA-dependent protein kinase PKR: structure and functionQ41614652
Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines.Q43845859
Toll-like receptors stimulate human neutrophil functionQ44493366
Toll-like receptor stimulation induces airway hyper-responsiveness to bradykinin, an effect mediated by JNK and NF-kappa B signaling pathwaysQ44817455
Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virusQ45173711
Virus- and bradykinin-induced airway hyperresponsiveness in guinea pigsQ45742538
Toll-like receptor 2, 3, and 4 expression and function in human airway smooth muscleQ59177740
Contribution of bradykinin B(1) and B(2) receptors in allergen-induced bronchial hyperresponsivenessQ73168538
APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNAQ75197384
H. influenzae potentiates airway epithelial cell responses to rhinovirus by increasing ICAM-1 and TLR3 expressionQ80129122
P921main subjectinflammationQ101991
toll-like receptorQ408004
P304page(s)43
P577publication date2009-06-01
P1433published inRespiratory ResearchQ7315904
P1476titleLong-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice
P478volume10

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