Salicylates dilate blood vessels through inhibiting PYK2-mediated RhoA/Rho-kinase activation

scientific article published on 10 March 2009

Salicylates dilate blood vessels through inhibiting PYK2-mediated RhoA/Rho-kinase activation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/CVR/CVP084
P932PMC publication ID2695702
P698PubMed publication ID19276129
P5875ResearchGate publication ID24191299

P2093author name stringRita C Tostes
Fernanda R C Giachini
Robert Clinton Webb
Zhekang Ying
P2860cites workSelectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenaseQ24563699
Differing administration time-dependent effects of aspirin on blood pressure in dipper and non-dipper hypertensivesQ28186501
Aspirin administered at bedtime, but not on awakening, has an effect on ambulatory blood pressure in hypertensive patientsQ28191955
Frequency of analgesic use and risk of hypertension in younger womenQ28193993
The effect of non-steroidal anti-inflammatory drugs and other commonly used non-narcotic analgesics on blood pressure level in adultsQ28199884
Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a Cox-independent mechanismQ28200590
Pyk2 regulates multiple signaling events crucial for macrophage morphology and migrationQ28505302
Role of endothelin-1 in blood pressure regulation in a rat model of visceral obesity and hypertensionQ28574724
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertensionQ29614247
Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphataseQ29615195
RAFTK/Pyk2-mediated cellular signallingQ33855347
Do nonsteroidal anti-inflammatory drugs affect blood pressure? A meta-analysisQ34726199
Rho-kinase, a potential therapeutic target for the treatment of hypertension.Q35987271
Rho-kinase as a molecular target for insulin resistance and hypertensionQ40355202
Altered PYK2 phosphorylation by ANG II in hypertensive vascular smooth muscleQ42515619
Sensitivity of rabbit aorta and mesenteric artery to norepinephrine: role of tyrosine kinasesQ44582082
Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aortaQ45061635
Tyrosine kinase participates in vasoconstriction through a Ca(2+)- and myosin light chain phosphorylation-independent pathwayQ45711496
Isoflavone attenuates vascular contraction through inhibition of the RhoA/Rho-kinase signaling pathwayQ46520472
Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular eventsQ46988581
Ovariectomy augments hypertension through rho-kinase activation in the brain stem in female spontaneously hypertensive ratsQ48434346
A meta-analysis of the effects of nonsteroidal anti-inflammatory drugs on blood pressureQ70565061
Salicylate Inhibits Phosphorylation of the Nonreceptor Tyrosine Kinases, Proline-Rich Tyrosine Kinase 2 and c-SrcQ73513446
Down-regulation by antisense oligonucleotides establishes a role for the proline-rich tyrosine kinase PYK2 in angiotensin ii-induced signaling in vascular smooth muscleQ73656443
Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in ratsQ79856645
Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertensionQ80980904
P433issue1
P304page(s)155-162
P577publication date2009-03-10
P1433published inCardiovascular ResearchQ4642329
P1476titleSalicylates dilate blood vessels through inhibiting PYK2-mediated RhoA/Rho-kinase activation
P478volume83

Reverse relations

cites work (P2860)
Q52661267A role for focal adhesion kinase in facilitating the contractile responses of murine gastric fundus smooth muscles.
Q38543448A role for the Ca(2+)-dependent tyrosine kinase Pyk2 in tonic depolarization-induced vascular smooth muscle contraction
Q40402700A role for the tyrosine kinase Pyk2 in depolarization-induced contraction of vascular smooth muscle
Q37727170Angiotensin II regulates the LARG/RhoA/MYPT1 axis in rat vascular smooth muscle in vitro
Q36456015Differential baseline expression and angiotensin II-stimulation of leukemia-associated RhoGEF in vascular smooth muscle cells of spontaneously hypertensive rats
Q36948503High-dose, but not low-dose, aspirin impairs anticontractile effect of ticagrelor following ADP stimulation in rat tail artery smooth muscle cells
Q42135553Membrane depolarization-induced RhoA/Rho-associated kinase activation and sustained contraction of rat caudal arterial smooth muscle involves genistein-sensitive tyrosine phosphorylation
Q37612304PYK2/PDZ-RhoGEF links Ca2+ signaling to RhoA.
Q38121505Potential benefits of rho-kinase inhibition in arterial hypertension
Q41231833ROS-dependent activation of RhoA/Rho-kinase in pulmonary artery: Role of Src-family kinases and ARHGEF1.
Q42058385Regulation of arterial reactivity by concurrent signaling through the E-prostanoid receptor 3 and angiotensin receptor 1.
Q37649264Regulation of smooth muscle contraction by small GTPases
Q54381205The inhibitory effect of simvastatin and aspirin on histamine responsiveness in human vascular endothelial cells.

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