PYK2/PDZ-RhoGEF links Ca2+ signaling to RhoA.

scientific article published on October 2009

PYK2/PDZ-RhoGEF links Ca2+ signaling to RhoA. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1161/ATVBAHA.109.190892
P932PMC publication ID3939713
P698PubMed publication ID19759375

P50authorRita C. TostesQ53818336
P2093author name stringR Clinton Webb
Fernanda R C Giachini
Zhekang Ying
P2860cites workThe crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscleQ24312384
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activationQ24312845
RhoGDI: multiple functions in the regulation of Rho family GTPase activitiesQ24534900
The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunitsQ24810130
Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinaseQ28215911
GEFs and GAPs: critical elements in the control of small G proteinsQ28304540
Pyk2 regulates multiple signaling events crucial for macrophage morphology and migrationQ28505302
Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive ratsQ28566535
A role for PYK2 in ANG II-dependent regulation of the PHAS-1-eIF4E complex by multiple signaling cascades in vascular smooth muscleQ28577743
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertensionQ29614247
Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphataseQ29615195
Ca2+, crossbridge phosphorylation, and contractionQ30459845
Translocation of rhoA associated with Ca2+ sensitization of smooth muscleQ30470267
RAFTK/Pyk2-mediated cellular signallingQ33855347
Vav-family proteins in T-cell signallingQ36123199
Coupling receptor tyrosine kinases to Rho GTPases--GEFs what's the linkQ36489466
Salicylates dilate blood vessels through inhibiting PYK2-mediated RhoA/Rho-kinase activationQ37225756
Rho-kinase as a molecular target for insulin resistance and hypertensionQ40355202
Pyk2 activation is integral to acid stimulation of sodium/hydrogen exchanger 3.Q40480548
Protein tyrosine phosphorylation, cellular Ca2+, and Ca2+ sensitivity for contraction of smooth muscleQ40537515
A rho exchange factor mediates thrombin and Galpha(12)-induced cytoskeletal responsesQ41689640
Altered PYK2 phosphorylation by ANG II in hypertensive vascular smooth muscleQ42515619
Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascular smooth muscle cellsQ42806407
A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin.Q42823002
Involvement of Rho-kinase and the actin filament network in angiotensin II-induced contraction and extracellular signal-regulated kinase activity in intact rat mesenteric resistance arteriesQ43702962
Ca2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contractionQ44550419
Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aortaQ45061635
Signal-crosstalk between Rho/ROCK and c-Jun NH2-terminal kinase mediates migration of vascular smooth muscle cells stimulated by angiotensin II.Q46580801
The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migrationQ46815318
Angiotensin II up-regulates the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF), a regulator of G protein signaling domain-containing RhoGEF, in vascular smooth muscle cells.Q54663029
Tyrosine kinase inhibitors and the contractile action of G-protein-linked vascular agonistsQ72503163
Calcium- and protein kinase C-dependent activation of the tyrosine kinase PYK2 by angiotensin II in vascular smooth muscleQ77426358
The role of the RhoA/Rho-kinase signaling pathway in renal vascular reactivity in endothelial nitric oxide synthase null miceQ79775525
Increaseed expression of mRNA for regulator of G protein signaling domain-containing Rho guanine nucleotide exchange factors in aorta from stroke-prone spontaneously hypertensive ratsQ80865532
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)1657-1663
P577publication date2009-10-01
P1433published inArteriosclerosis, Thrombosis, and Vascular BiologyQ4797542
P1476titlePYK2/PDZ-RhoGEF links Ca2+ signaling to RhoA
P478volume29

Reverse relations

cites work (P2860)
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Q35873096Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin Polymerization
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