Structure and function of a new class of human prolactin antagonists

scientific article published on 21 February 2009

Structure and function of a new class of human prolactin antagonists is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.PEP.2009.02.012
P932PMC publication ID2696313
P698PubMed publication ID19236917
P5875ResearchGate publication ID24034633

P2093author name stringCharles L Brooks
Laura DePalatis
Colleen M Almgren
Jypji Patmastan
Mark Troyer
Todd Woodrich
P2860cites workIsolation and characterization of two novel forms of the human prolactin receptor generated by alternative splicing of a newly identified exon 11.Q48346695
Ligand-independent dimerization of the human prolactin receptor isoforms: functional implicationsQ50335953
Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity.Q50509935
Ligand-independent homo- and heterodimerization of human prolactin receptor variants: inhibitory action of the short forms by heterodimerization.Q50735815
Development of pure prolactin receptor antagonists.Q54522912
Human prolactin and its antagonist, hPRL-G129R, regulate bax and bcl-2 gene expression in human breast cancer cells and transgenic mice.Q54740174
Solution Structure of Human ProlactinQ58045319
Identification of residues outside the two binding sites that are critical for activation of the lactogenic activity of human growth hormoneQ73229487
The Tertiary Structure and Backbone Dynamics of Human ProlactinQ73348924
Regulation of bcl-2 gene expression in human breast cancer cells by prolactin and its antagonist, hPRL-G129RQ74519757
The 20-kilodalton (kDa) human growth hormone (hGH) differs from the 22-kDa hGH in the effect on the human prolactin receptorQ78180884
Multiple new isoforms of the human prolactin receptor geneQ80599448
Functional characterization of the intermediate isoform of the human prolactin receptorQ22010878
Human growth hormone and extracellular domain of its receptor: crystal structure of the complexQ24308045
The X-ray structure of a growth hormone-prolactin receptor complexQ24309612
Measurement of protein using bicinchoninic acidQ26778491
Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: X-ray structure of Del1-9-G129R-hPRLQ27647816
Probability-based protein identification by searching sequence databases using mass spectrometry dataQ27860736
Identification of a cDNA encoding a long form of prolactin receptor in human hepatoma and breast cancer cellsQ28118923
Characterization of EBV-genome negative “null” and “T” cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphomaQ28273953
Identification and characterization of the prolactin-binding protein in human serum and milkQ30666842
Comprehensive analysis of a multidimensional liquid chromatography mass spectrometry dataset acquired on a quadrupole selecting, quadrupole collision cell, time-of-flight mass spectrometer: II. New developments in Protein Prospector allow for reliabQ33216495
Quantitation of mitochondrial alterations associated with apoptosisQ34693198
Prolactin as an autocrine/paracrine growth factor in human cancer.Q34750801
The role of prolactin in mammary carcinomaQ35067253
Endocrinology of lactationQ35953966
Development and potential clinical uses of human prolactin receptor antagonistsQ36091070
Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.Q36364876
Therapeutic potential of S179D prolactin--from prostate cancer to angioproliferative disorders: the first selective prolactin receptor modulatorQ36600303
Prolactin and murine mammary tumorigenesis: a reviewQ37360895
Efficient site-directed mutagenesis using uracil-containing DNA.Q37479506
The high- and low-affinity receptor binding sites of growth hormone are allosterically coupledQ37704566
Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding proteinQ38357814
Human growth hormone DNA sequence and mRNA structure: possible alternative splicingQ40499454
Characterization of a novel and functional human prolactin receptor isoform (deltaS1PRLr) containing only one extracellular fibronectin-like domainQ40701052
A human prolactin antagonist, hPRL-G129R, inhibits breast cancer cell proliferation through induction of apoptosis.Q40787118
The growth hormone/prolactin receptor familyQ40880513
Prolactin is an autocrine growth factor for the Jurkat human T-leukemic cell lineQ41080651
Antagonistic properties of human prolactin analogs that show paradoxical agonistic activity in the Nb2 bioassayQ41185295
Prolactin Suppresses Glucocorticoid-Induced Thymocyte Apoptosis in VivoQ42439832
In vitro studies of a prolactin antagonist, hPRL-G129R in human breast cancer cellsQ43511895
Prolactin and the development and progression of early neoplastic mammary gland lesionsQ44794490
Different elements of mini-helix 1 are required for human growth hormone or prolactin action via the prolactin receptorQ44977009
Mechanism for ordered receptor binding by human prolactinQ45123438
The role of human prolactin and its antagonist, G129R, in mammary gland development and DMBA-initiated tumorigenesis in transgenic mice.Q46740791
A naturally occurring structural variant of human growth hormoneQ48195456
Expression, folding, and characterization of small proteins with increasing disulfide complexity by a pT7-7-derived phagemidQ48280667
P433issue2
P304page(s)121-130
P577publication date2009-02-21
P1433published inProtein Expression and PurificationQ7251430
P1476titleStructure and function of a new class of human prolactin antagonists
P478volume66

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cites work (P2860)
Q27646645Crystal Structure of an Affinity-matured Prolactin Complexed to Its Dimerized Receptor Reveals the Topology of Hormone Binding Site 2
Q27664687Structural Characterization of the Stem–Stem Dimerization Interface between Prolactin Receptor Chains Complexed with the Natural Hormone

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