Emerging treatments for postmenopausal osteoporosis - focus on denosumab

scientific article published on 09 June 2009

Emerging treatments for postmenopausal osteoporosis - focus on denosumab is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.2147/CIA.S3333
P932PMC publication ID2697589
P698PubMed publication ID19554095

P2093author name stringPiet Geusens
P2860cites workOsteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
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osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcificationQ24603266
Giant osteoclast formation and long-term oral bisphosphonate therapyQ24626459
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
The role of osteoprotegerin in arthritisQ24797889
Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysisQ28141482
Denosumab in postmenopausal women with low bone mineral densityQ28298728
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiationQ28505419
The distribution of secondary growths in cancer of the breast. 1889Q29614314
Genetic regulation of osteoclast development and functionQ29617421
Osteoprotegerin treatment impairs remodeling and apparent material properties of callus tissue without influencing structural fracture strengthQ31157658
Noninvasive diagnosis of ruptured peripheral atherosclerotic lesions and myocardial infarction by antibody profilingQ33355010
Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing.Q33385262
Effects of denosumab on bone mineral density and bone turnover in postmenopausal womenQ34656025
Randomized trial of denosumab in patients receiving adjuvant aromatase inhibitors for nonmetastatic breast cancerQ34813227
Bone and joint destruction in rheumatoid arthritis: what is really happening?Q34866256
Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritisQ35764588
Clinical development of anti-RANKL therapyQ35901092
TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factorQ36380989
Preliminary evidence for a structural benefit of the new bisphosphonate zoledronic acid in early rheumatoid arthritisQ56420412
Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trialQ57752107
Bisphosphonate-Associated Osteonecrosis of the Jaw: Report of a Task Force of the American Society for Bone and Mineral ResearchQ58216587
Two-Year Treatment With Denosumab (AMG 162) in a Randomized Phase 2 Study of Postmenopausal Women With Low BMDQ58971166
Suggested Sequential Mode of Control of Changes in Cell Behaviour in Adult Bone RemodellingQ59076842
Randomized Active-Controlled Phase II Study of Denosumab Efficacy and Safety in Patients With Breast Cancer-Related Bone MetastasesQ62392239
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Osteoclastogenesis inhibitory factor exhibits hypocalcemic effects in normal mice and in hypercalcemic nude mice carrying tumors associated with humoral hypercalcemia of malignancyQ77690444
Advances in the biology and treatment of myeloma bone diseaseQ78769316
Eating bone or adding it: the Wnt pathway decidesQ79751142
Targeted ablation of osteocytes induces osteoporosis with defective mechanotransductionQ80432871
RANKL protein is expressed at the pannus-bone interface at sites of articular bone erosion in rheumatoid arthritisQ82615147
The ratio of circulating osteoprotegerin to RANKL in early rheumatoid arthritis predicts later joint destructionQ83880460
Bone quality--the material and structural basis of bone strength and fragilityQ36488553
Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease.Q36860987
Drug Insight: choosing a drug treatment strategy for women with osteoporosis-an evidence--based clinical perspective.Q37132710
Quantum concept of bone remodeling and turnover: Implications for the pathogenesis of osteoporosisQ39693077
Role of osteoblasts in hormonal control of bone resorption—A hypothesisQ41551873
The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts.Q41649459
Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing.Q42505465
Preference and satisfaction with a 6-month subcutaneous injection versus a weekly tablet for treatment of low bone massQ43297986
The effect of a single dose of osteoprotegerin in postmenopausal womenQ43520860
Two year randomized controlled trial of etidronate in rheumatoid arthritis: changes in serum aminoterminal telopeptides correlate with radiographic progression of diseaseQ44334690
Effects of high dose IV pamidronate on disease activity and bone metabolism in patients with active RA: a randomized, double-blind, placebo-controlled trial.Q44579771
A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal womenQ46133598
The deceiving appearances of osteoclastsQ46178064
Extended efficacy and safety of denosumab in breast cancer patients with bone metastases not receiving prior bisphosphonate therapyQ46312540
Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trialQ46393065
Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: a randomized blinded phase 2 clinical trialQ46551911
Effects of denosumab on the geometry of the proximal femur in postmenopausal women in comparison with alendronateQ46582756
A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancerQ46952812
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectosteoporosisQ165328
peptideQ172847
globulinsQ321710
monoclonal antibodyQ422248
blood proteinsQ425056
postmenopausal osteoporosisQ55950294
P304page(s)241-250
P577publication date2009-06-09
P1433published inClinical Interventions in AgingQ5133768
P1476titleEmerging treatments for postmenopausal osteoporosis - focus on denosumab
P478volume4

Reverse relations

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