Systems Pharmacology Dissection of the Integrated Treatment for Cardiovascular and Gastrointestinal Disorders by Traditional Chinese Medicine

scientific article published on 06 September 2016

Systems Pharmacology Dissection of the Integrated Treatment for Cardiovascular and Gastrointestinal Disorders by Traditional Chinese Medicine is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SREP32400
P932PMC publication ID5011655
P698PubMed publication ID27597117

P50authorZihu GuoQ61108142
Mohamed ShahenQ61108146
Yingxue FuQ61137649
P2093author name stringYonghua Wang
Jun Xue
Wenjuan Zhang
Wei Xiao
Zhenzhong Wang
Qin Tao
Xuetong Chen
Jinglin Zhu
Piar Ali Shar
Ziyin Wu
Yaofei Bai
P2860cites workDoes gastro-esophageal reflux provoke the myocardial ischemia in patients with CAD?Q46682563
Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in ratsQ46928591
The relationship between heart and stomach in Iranian traditional medicine: a new concept in cardiovascular disease management.Q47177811
Linkage and association of adrenergic and dopamine receptor genes in the distal portion of the long arm of chromosome 5 with systolic blood pressure variationQ47700987
Systems approaches and polypharmacology for drug discovery from herbal medicines: an example using licoriceQ47784795
Association of 5-HTR2A and 5-HTR2C serotonin receptor gene polymorphisms with depression risk in patients with coronary heart diseaseQ48305576
Systems pharmacology in drug discovery and therapeutic insight for herbal medicinesQ48465967
BioGPS: an extensible and customizable portal for querying and organizing gene annotation resourcesQ21183895
DrugBank: a comprehensive resource for in silico drug discovery and explorationQ24188653
KEGG: kyoto encyclopedia of genes and genomesQ24515297
Cytoscape: a software environment for integrated models of biomolecular interaction networksQ24515682
Ayurveda and traditional Chinese medicine: a comparative overviewQ24812529
Nitric oxide: physiology, pathophysiology, and pharmacologyQ26778243
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
Chemical Similarity SearchingQ28090770
Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trialQ28182767
Emerging features in the regulation of MMP-9 gene expression for the development of novel molecular targets and therapeutic strategiesQ28210187
Luteolin improves contractile function and attenuates apoptosis following ischemia-reperfusion in adult rat cardiomyocytesQ50437029
Milk-derived peptides, Val-Pro-Pro and Ile-Pro-Pro, attenuate atherosclerosis development in apolipoprotein e-deficient mice: a preliminary study.Q51029807
Patients with chronic gastrointestinal ischemia have a higher cardiovascular disease risk and mortality.Q51320520
Prediction of n-octanol/water partition coefficients from PHYSPROP database using artificial neural networks and E-state indices.Q52053484
Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis.Q53549680
Characterization of metabolites of tanshinone IIA in rats by liquid chromatography/tandem mass spectrometryQ57269480
Endoscopic controlled trial of four drug regimens in the treatment of chronic duodenal ulcerationQ69896532
Congenital Cardiovascular Disease and Anomalies of the Third and Fourth Pharyngeal PouchQ70408532
Deglycyrrhizinised liquorice (DGL) and the renewal of rat stomach epitheliumQ70825627
Differential changes in left and right ventricular adenylyl cyclase activities in congestive heart failureQ73281722
Diarylheptanoids from Alpinia officinarumQ79393556
The evaluation of nitric oxide scavenging activity of certain Indian medicinal plants in vitro: a preliminary studyQ80596643
The effect of double dose of omeprazole on the course of angina pectoris and treadmill stress test in patients with coronary artery disease--a randomised, double-blind, placebo controlled, crossover trialQ80774966
The number of lymph node metastases in gastric cancer correlates with the angiotensin I-converting enzyme gene insertion/deletion polymorphismQ81621768
Role of endogenous nitric oxide in mucosal defense of inflamed rat stomach following iodoacetamide treatmentQ83858161
Gastroprotective action of Cissus quadrangularis extract against NSAID induced gastric ulcer: role of proinflammatory cytokines and oxidative damageQ28219475
The potential role of honey and its polyphenols in preventing heart diseases: a reviewQ28242454
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decadeQ28288148
Network pharmacology: the next paradigm in drug discoveryQ28297997
A review on the dietary flavonoid kaempferolQ28307823
A system-level investigation into the mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for cardiovascular disease treatmentQ28483412
A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological dataQ28484011
Hepatitis B virus infection in Latin America: a genomic medicine approachQ28657861
PharmGKB: an integrated resource of pharmacogenomic data and knowledgeQ33372157
Phospholipase A(2) enzymes in metabolic and cardiovascular diseasesQ33773427
Helicobacter pylori: from the stomach to the heartQ33774677
Regulation of the expression of the inflammatory nitric oxide synthase (NOS2) by cyclic AMP.Q33792310
Atrial fibrillation in patients with gastroesophageal reflux disease: a comprehensive reviewQ33948440
Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (AQ33989952
Effects of (-)-epicatechin on myocardial infarct size and left ventricular remodeling after permanent coronary occlusionQ34042151
Does nitric oxide modulate mitochondrial energy generation and apoptosis?Q34127186
Ryanodine receptors/calcium release channels in heart failure and sudden cardiac deathQ34198372
Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trialQ34246898
Towards the identification of protein complexes and functional modules by integrating PPI network and gene expression dataQ34279008
Nitric oxide in immunity and inflammationQ34342605
HINT: High-quality protein interactomes and their applications in understanding human diseaseQ34356822
Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasisQ34415813
Estrogen receptor activation and cardioprotection in ischemia reperfusion injuryQ34447516
HIT: linking herbal active ingredients to targetsQ34456364
Bioavailability and bioequivalence: an FDA regulatory overviewQ34489341
Ginger: an ethnomedical, chemical and pharmacological reviewQ34494797
Disruption of type 5 adenylyl cyclase prevents β-adrenergic receptor cardiomyopathy: a novel approach to β-adrenergic receptor blockadeQ34519386
Effect and mechanism of action of isosorbide-5-mononitrateQ34530357
The relationship between infection, inflammation, and cardiovascular disease: an overviewQ34557639
Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9Q34786508
Network analyses in systems pharmacologyQ34995155
Effects of natural products on ischemic heart diseases and cardiovascular system.Q35017045
PDE3 cyclic nucleotide phosphodiesterases and the compartmentation of cyclic nucleotide-mediated signalling in cardiac myocytes.Q35024246
Omega-3 PUFAs induce apoptosis of gastric cancer cells via ADORA1.Q38988415
Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancerQ39012316
Expression of estrogen receptors in gastric cancer and their clinical significanceQ39378829
Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathwayQ39930080
Molecular and cellular biology of the senescent hypertrophied and failing heartQ40380052
alpha- and beta-adrenergic pathways differentially regulate cell type-specific apoptosis in rat cardiac myocytesQ40941082
Role of dietary flavonoids in protection against cancer and coronary heart diseaseQ41173461
The common biological basis for common complex diseases: evidence from lipoprotein lipase geneQ41739972
The potential benefit of complementary/alternative medicine in cardiovascular diseasesQ42010362
Role of cGMP-PKG signaling in the protection of neonatal rat cardiac myocytes subjected to simulated ischemia/reoxygenationQ43116126
The impact of cellular networks on disease comorbidityQ43125319
Vitamin C, vitamin E, and multivitamin supplement use and stomach cancer mortality in the Cancer Prevention Study II cohortQ43869260
Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressureQ43908096
Boldine protects endothelial function in hyperglycemia-induced oxidative stress through an antioxidant mechanism.Q44211889
Flavonoids, vitamin C and adenocarcinoma of the stomachQ44768687
PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice.Q45023435
Protective effect of ginger, Zingiber officinale Rosc on experimental atherosclerosis in rabbits.Q45037957
Activation of estrogen receptor-alpha protects the in vivo rabbit heart from ischemia-reperfusion injuryQ46581030
???Q94737227
Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiologyQ35037364
Xiangshaliujunzi Decoction for the treatment of diabetic gastroparesis: a systematic reviewQ35103674
Drug-target network in myocardial infarction reveals multiple side effects of unrelated drugsQ35551379
Modeling of intestinal drug absorption: roles of transporters and metabolic enzymes (for the Gillette Review Series).Q35587726
Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery.Q35631111
Human Phenome based on traditional Chinese medicine--a solution to congenital syndromologyQ35679006
Absorption and metabolism of flavonoidsQ35690769
Systems Pharmacology Dissecting Holistic Medicine for Treatment of Complex Diseases: An Example Using Cardiocerebrovascular Diseases Treated by TCMQ35697884
Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosisQ35742409
Cytochrome P450 regulation and drug biotransformation during inflammation and infectionQ35793938
Large-scale Direct Targeting for Drug Repositioning and Discovery.Q35833951
Mechanisms of glucocorticoid receptor signaling during inflammationQ35947911
Role of soluble adenylyl cyclase in the heartQ35964984
Alterations in cAMP-mediated signaling and their role in the pathophysiology of dilated cardiomyopathyQ36241719
Tanshinones: sources, pharmacokinetics and anti-cancer activitiesQ36396623
The Comparative Toxicogenomics Database: update 2013.Q36491395
Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases.Q36622456
Renin-angiotensin system and cardiovascular riskQ36784673
The role of nitric oxide in inflammatory reactionsQ36954629
Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent researchQ36976622
Pathway analysis of seven common diseases assessed by genome-wide associationQ37014849
Licorice: a possible anti-inflammatory and anti-ulcer drugQ37360681
Structure and organization of drug-target networks: insights from genomic approaches for drug discoveryQ37599365
Recent advances on HPLC/MS in medicinal plant analysisQ37815973
Atrial fibrillation and acid reflux disease.Q37982664
Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular diseaseQ38059011
Selection of a mineralocorticoid receptor antagonist for patients with hypertension or heart failureQ38182029
Adenylyl cyclases in the digestive system.Q38187513
Network pharmacology: a Rosetta Stone for traditional Chinese medicineQ38243629
Microbial biotransformation of bioactive flavonoidsQ38275162
Systems pharmacology strategies for drug discovery and combination with applications to cardiovascular diseasesQ38314138
A novel chemometric method for the prediction of human oral bioavailabilityQ38323150
Gadd45beta is a novel mediator of cardiomyocyte apoptosis induced by ischaemia/hypoxiaQ38488490
Tissue-specific transplantation antigen P35B (TSTA3) immune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by biocomputationQ38497502
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectpharmacologyQ128406
traditional Chinese medicineQ200253
P304page(s)32400
P577publication date2016-09-06
P1433published inScientific ReportsQ2261792
P1476titleSystems Pharmacology Dissection of the Integrated Treatment for Cardiovascular and Gastrointestinal Disorders by Traditional Chinese Medicine
P478volume6

Reverse relations

cites work (P2860)
Q64274684A Novel Discovery: Holistic Efficacy at the Special Organ Level of Pungent Flavored Compounds from Pungent Traditional Chinese Medicine
Q64916094Acupuncture and Neural Mechanism in the Management of Low Back Pain-An Update.
Q99557329Mechanisms of indigo naturalis on treating ulcerative colitis explored by GEO gene chips combined with network pharmacology and molecular docking
Q43947854Network pharmacology exploration reveals endothelial inflammation as a common mechanism for stroke and coronary artery disease treatment of Danhong injection
Q59335213Network pharmacology-based identification of major component of and its action mechanism for the treatment of acute myocardial infarction
Q98177902Systematic Elucidation of the Mechanism of Oroxylum indicum via Network Pharmacology
Q51050981Systematic Understanding of the Mechanism of Salvianolic Acid A via Computational Target Fishing.
Q64075810Systematic elucidation of the mechanism of geraniol via network pharmacology
Q33809040Systems Pharmacological Approach of Pulsatillae Radix on Treating Crohn's Disease
Q90536722Systems Pharmacological Approach to Investigate the Mechanism of Acori Tatarinowii Rhizoma for Alzheimer's Disease
Q47145365Systems Pharmacological Approach to the Effect of Bulsu-san Promoting Parturition.
Q92403114Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery
Q91791008Unraveling the action mechanism of polygonum cuspidatum by a network pharmacology approach

Search more.