The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09.

scientific article published on 26 June 2013

The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/RHEUMATOLOGY/KET219
P932PMC publication ID3798713
P698PubMed publication ID23804219
P5875ResearchGate publication ID242333555

P50authorPaul BownessQ56942640
Alessandra VaccaQ59676931
Matteo PigaQ37829183
Giorgio La NasaQ37830557
P2093author name stringChristoph Renner
Simon Kollnberger
Sravan Payeli
Alberto Cauli
Alessandro Mathieu
Pietro Garau
Jacqueline Shaw
Amanda Carette
Carlos López-Larrea
Kirsty McHugh
Hiroko Hatano
Soraya Hölper
Miguel Angel Blanco-Gelaz
Giovanni Porru
Oliwia Rysnik
Valentina Ibba
Elisabetta Desogus
Grazia Dessole
Joanna Giles
Sarah Fiedler
P2860cites workRapid detection of all HLA-B*27 alleles (B*2701-B*2725) by group-specific polymerase chain reaction.Q54739480
Free HLA class I heavy chain-carrying monocytes--a potential role in the pathogenesis of spondyloarthropathiesQ74141459
[The role of HLA-B27 molecules in the pathogenesis of ankylosing spondylitis]Q78439108
Cell-surface expression and immune receptor recognition of HLA-B27 homodimersQ78505485
Interaction of HLA-B27 homodimers with KIR3DL1 and KIR3DL2, unlike HLA-B27 heterotrimers, is independent of the sequence of bound peptideQ80094575
Thermodynamic and structural analysis of peptide- and allele-dependent properties of two HLA-B27 subtypes exhibiting differential disease associationQ27642338
Dual, HLA-B27 Subtype-dependent Conformation of a Self-peptideQ27642989
NK cell recognitionQ29615107
Beta 2-microglobulin-free HLA class I heavy chain epitope mimicry by monoclonal antibody HC-10-specific peptideQ31152009
HLA class I associations of ankylosing spondylitis in the white population in the United Kingdom.Q33578883
Inhibiting HLA-B27 homodimer-driven immune cell inflammation in spondylarthritis.Q34265730
The LILR family: modulators of innate and adaptive immune pathways in health and disease.Q34340048
KIR expression shapes cytotoxic repertoires: a developmental program of survivalQ34584964
Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d)Q35133849
Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitisQ35534758
The pathogenetic role of HLA-B27 and its subtypesQ36731856
KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitisQ37076771
Progress in spondylarthritis. Immunopathogenesis of spondyloarthritis: which cells drive disease?Q37547278
The role of B27 heavy chain dimer immune receptor interactions in spondyloarthritis.Q37592176
HLA-B27 homodimers and free H chains are stronger ligands for leukocyte Ig-like receptor B2 than classical HLA class I.Q39739585
Class I HLA folding and antigen presentation in beta 2-microglobulin-defective Daudi cellsQ39876473
Novel detection of in vivo HLA-B27 conformations correlates with ankylosing spondylitis associationQ39922842
Expansion and enhanced survival of natural killer cells expressing the killer immunoglobulin-like receptor KIR3DL2 in spondylarthritisQ40357001
Allele-dependent similarity between viral and self-peptide presentation by HLA-B27 subtypesQ40493543
HLA-B27 heavy chain homodimers are expressed in HLA-B27 transgenic rodent models of spondyloarthritis and are ligands for paired Ig-like receptors.Q40533173
Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling.Q40666712
Differential association of HLA-B*2705 and B*2709 to ankylosing spondylitis correlates with limited peptide subsets but not with altered cell surface stabilityQ40728026
HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulumQ40735553
Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structureQ40956687
HLA-B27 structure, function, and disease association.Q41157905
HLA-B∗0702 antibody epitopes are affected indirectly by distant antigen residuesQ41577346
Follow the leader: NK cell receptors for classical and nonclassical MHC class I.Q41732625
Different HLA-B27 subtypes present the same immunodominant Epstein-Barr virus peptideQ41780808
Structural and functional analysis of monomorphic determinants recognized by monoclonal antibodies reacting with the HLA class I alpha 3 domainQ43714881
Relevance of residue 116 of HLA-B27 in determining susceptibility to ankylosing spondylitis.Q43814358
HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptidesQ45151315
A nucleoprotein peptide of influenza A virus stimulates assembly of HLA-B27 class I heavy chains and beta 2-microglobulin translated in vitroQ45849901
HLA-B27 polymorphism at position 116 critically influences the association with TAP/tapasin, intracellular trafficking and conformational homodimers formationQ46148610
Consistent patterns of expression of HLA class I free heavy chains in healthy individuals and raised expression in spondyloarthropathy patients point to physiological and pathological roles.Q48546469
Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells.Q52020036
P433issue11
P304page(s)1952-1962
P577publication date2013-06-26
P1433published inRheumatologyQ7320492
P1476titleThe arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09
P478volume52

Reverse relations

cites work (P2860)
Q36866358Activation-Induced Killer Cell Immunoglobulin-like Receptor 3DL2 Binding to HLA-B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis
Q88698604Allele-specific Alterations in the Peptidome Underlie the Joint Association of HLA-A*29:02 and Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with Birdshot Chorioretinopathy
Q39177486Associations between polymorphisms of HLA-B gene and postmenopausal osteoporosis in Chinese Han population
Q38912297Current perspective on the role of the interleukin-23/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis).
Q58803841Distinct mechanisms survey the structural integrity of HLA-B*27:05 intracellularly and at the surface
Q64981419Expression analysis of HLA-E and NKG2A and NKG2C receptors points at a role for natural killer function in ankylosing spondylitis.
Q89303279Expression and Metabolomic Profiling in Axial Spondyloarthritis
Q92052787HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications
Q38266317Killer-cell immunoglobulin-like receptors (KIR) and HLA-class I heavy chains in ankylosing spondylitis.
Q51530811Multi-modal Binding of a 'Self' Peptide by HLA-B*27:04 and B*27:05 Allelic Variants, but not B*27:09 or B*27:06 Variants: Fresh Support for Some Theories Explaining Differential Disease Association.
Q36913820Non-conventional forms of HLA-B27 are expressed in spondyloarthritis joints and gut tissue.
Q38959953Peptide handling by HLA-B27 subtypes influences their biological behavior, association with ankylosing spondylitis and susceptibility to endoplasmic reticulum aminopeptidase 1 (ERAP1).
Q33987886Presence of the full-length KIR2DS4 gene reduces the chance of rheumatoid arthritis patients to respond to methotrexate treatment
Q37720215Role of HLA-B27 in the pathogenesis of ankylosing spondylitis (Review).
Q48002099Spondyloarthropathies: Ligand-receptor interactions implicated in pathogenesis
Q35670468The Leukocyte Immunoglobulin-Like Receptor Family Member LILRB5 Binds to HLA-Class I Heavy Chains.
Q35564107The danger model approach to the pathogenesis of the rheumatic diseases
Q40101435The interplay between HLA-B27 and ERAP1/ERAP2 aminopeptidases: from anti-viral protection to spondyloarthritis.
Q52881483The investigation of killer cell immunoglobulin-like receptor genotyping in patients with systemic lupus erytematosus and systemic sclerosis.
Q90660254Two Lineages of KLRA with Contrasting Transcription Patterns Have Been Conserved at a Single Locus during Ruminant Speciation
Q88126401WITHDRAWN: Associations between polymorphisms of HLA-B gene and postmenopausal osteoporosis in Chinese Han population

Search more.