Age-dependent differences in the inhibition of HCN2 current in rat ventricular myocytes by the tyrosine kinase inhibitor erbstatin

scientific article published on 12 August 2008

Age-dependent differences in the inhibition of HCN2 current in rat ventricular myocytes by the tyrosine kinase inhibitor erbstatin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00424-008-0565-7
P932PMC publication ID2701652
P698PubMed publication ID18696104
P5875ResearchGate publication ID23164694

P2093author name stringRichard B Robinson
Yelena Kryukova
Susan F Steinberg
Jihong Qu
Vitalyi O Rybin
P2860cites workI K1 and I f in ventricular myocytes isolated from control and hypertrophied rat heartsQ82183813
Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cellsQ28218949
Disinactivation of N-type inactivation of voltage-gated K channels by an erbstatin analogueQ28261102
Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotideQ28364054
Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein-protein interactionQ28569156
MiRP1 modulates HCN2 channel expression and gating in cardiac myocytesQ28571262
Regulation of HCN channel surface expression by a novel C-terminal protein-protein interactionQ28586966
A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinaseQ28592015
Interaction of the pacemaker channel HCN1 with filamin A.Q33205475
Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissuesQ33867597
Constitutively active Src tyrosine kinase changes gating of HCN4 channels through direct binding to the channel proteinsQ35215363
Genes, stem cells and biological pacemakersQ35886096
Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2Q36295878
Potassium channel phosphorylation in excitable cells: providing dynamic functional variability to a diverse family of ion channelsQ37082375
Src tyrosine kinase alters gating of hyperpolarization-activated HCN4 pacemaker channel through Tyr531.Q37445040
Direct inhibition of the pacemaker (If) current in rabbit sinoatrial node cells by genistein.Q38738342
Inhibition of Abelson oncogene function by erbstatin analogues.Q40662411
The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinasesQ40684182
Tyrosine kinase-independent inhibition of cyclic-AMP phosphodiesterase by genistein and tyrphostin 51.Q40950881
Modulation of cyclic AMP levels in a clonal neural cell line by inhibitors of tyrosine phosphorylationQ41110591
Effects of protein kinase inhibitors on canine Purkinje fibre pacemaker depolarization and the pacemaker current i(f)Q41149915
The contribution of the 'pacemaker' current (if) to generation of spontaneous activity in rabbit sino-atrial node myocytesQ41183437
Inhibition by genistein of the hyperpolarization-activated cation current in porcine sino-atrial node cellsQ42047413
HCN2 overexpression in newborn and adult ventricular myocytes: distinct effects on gating and excitabilityQ42506846
Action of internal pronase on the f-channel kinetics in the rabbit SA node.Q42612910
Proto-oncogene expression in proliferating and differentiating cardiac and skeletal muscleQ42857101
Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissuesQ43542437
Inhibition of protein kinase C by the tyrosine kinase inhibitor erbstatinQ43852688
Tyrosine kinase inhibition differentially regulates heterologously expressed HCN channelsQ44666971
Pacemaking by HCN channels requires interaction with phosphoinositidesQ48333850
Neuropeptide Y contributes to innervation-dependent increase in I(Ca, L) via ventricular Y2 receptors.Q52174552
Developmental change in the voltage-dependence of the pacemaker current, if, in rat ventricle cells.Q52196629
Epidermal growth factor increases i(f) in rabbit SA node cells by activating a tyrosine kinase.Q53831073
The Properties of the Pacemaker Current IFin Human Ventricular Myocytes are Modulated by Cardiac DiseaseQ59591148
A serum-free, chemically-defined medium for function and growth of primary neonatal rat heart cell culturesQ70990470
Epidermal growth factor produces inotropic and chronotropic effects in rat hearts by increasing cyclic AMP accumulationQ72956103
Phosphatase inhibition by calyculin A increases i(f) in canine Purkinje fibers and myocytesQ72964047
Differential control of the hyperpolarization-activated current (i(f)) by cAMP gating and phosphatase inhibition in rabbit sino-atrial node myocytesQ73362911
Tyrosine kinase inhibition reduces i(f) in rabbit sinoatrial node myocytesQ73555639
Comparison of ion-channel subunit expression in canine cardiac Purkinje fibers and ventricular muscleQ78460665
P433issue4
P304page(s)821-830
P577publication date2008-08-12
P1433published inPfluegers ArchivQ1091689
P1476titleAge-dependent differences in the inhibition of HCN2 current in rat ventricular myocytes by the tyrosine kinase inhibitor erbstatin
P478volume457

Reverse relations

cites work (P2860)
Q35947167Ca2+-activated adenylyl cyclase 1 introduces Ca2+-dependence to beta-adrenergic stimulation of HCN2 current
Q37310450Gene therapy to treat cardiovascular disease
Q37547401The cardiac pacemaker current

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