Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies

scientific article published on August 2008

Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1472-8206.2008.00608.X
P698PubMed publication ID18705745
P5875ResearchGate publication ID23173393

P2093author name stringBernard Fromenty
Gilles Labbe
Dominique Pessayre
P2860cites workEffects of alcohol and oxidative stress on liver pathology: the role of the mitochondrionQ34689211
PerhexilineQ36795930
Mitochondrial damage associated with long-term antiretroviral treatment: associated alteration or causal disorder?Q40621030
Immunological study of the tissue expression of D-beta-hydroxybutyrate dehydrogenase, a ketone body-converting enzymeQ48255495
P433issue4
P921main subjectmitochondrionQ39572
P304page(s)335-353
P577publication date2008-08-01
P1433published inFundamental and Clinical PharmacologyQ15760364
P1476titleDrug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies
P478volume22

Reverse relations

cites work (P2860)
Q39483338A High Dose of Isoniazid Disturbs Endobiotic Homeostasis in Mouse Liver
Q43528067A high content screening assay to predict human drug-induced liver injury during drug discovery
Q46364739A lipidomic cell-based assay for studying drug-induced phospholipidosis and steatosis
Q42707141A simple transcriptomic signature able to predict drug-induced hepatic steatosis.
Q46408637Allicin enhances chemotherapeutic response and ameliorates tamoxifen-induced liver injury in experimental animals
Q37706542Analysis of molecular mechanisms of 5-fluorouracil-induced steatosis and inflammation in vitro and in mice
Q57037050Ascorbic acid inhibits visceral obesity and nonalcoholic fatty liver disease by activating peroxisome proliferator-activated receptor α in high-fat-diet-fed C57BL/6J mice
Q42354312CSH guidelines for the diagnosis and treatment of drug-induced liver injury
Q26749054Case Characterization, Clinical Features and Risk Factors in Drug-Induced Liver Injury
Q30278737Chronic liver injury induced by drugs: a systematic review.
Q34668643Comparative proteomics study on liver mitochondria of primary biliary cirrhosis mouse model
Q55920548DeepTox: Toxicity Prediction using Deep Learning
Q37251993Determination of intracellular unbound concentrations and subcellular localization of drugs in rat sandwich-cultured hepatocytes compared with liver tissue.
Q55345230Drug-Induced Liver Injury: An Institutional Case Series and Review of Literature.
Q38845891Drug-induced hepatotoxicity in cancer patients - implication for treatment
Q56541717Drug-induced steatohepatitis
Q91789694Dyslipidemia is a Risk Factor for the Incidence and Severity of Drug-Induced Liver Injury (DILI): A Retrospective Population-Based Study in China
Q43181274Effect of dietary monosodium glutamate on HFCS-induced hepatic steatosis: expression profiles in the liver and visceral fat.
Q41679878Effects of 4-nonylphenol on oxidant/antioxidant balance system inducing hepatic steatosis in male rat.
Q92604420Effects of N-acetyl cysteine, vitamin E and vitamin C on liver glutathione levels following amiodarone treatment in rats
Q54937303Effects of mid-respiratory chain inhibition on mitochondrial function in vitro and in vivo.
Q59132384Efficacy of sertraline against : an in vitro and in silico study
Q34219621Enhanced oxidative stress and increased mitochondrial mass during efavirenz-induced apoptosis in human hepatic cells
Q28069617Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man
Q64069758Experimental observation of mitochondrial oxidative damage of liver cells induced by isonicotinic acid hydrazide
Q37756278Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening
Q34715847Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway
Q38793908High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis
Q28479257High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria
Q58680687High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins
Q38383132High-content screening technology for studying drug-induced hepatotoxicity in cell models.
Q34786843High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury
Q35781121Identification of a Mitochondrial DNA Polymerase Affecting Cardiotoxicity of Sunitinib Using a Genome-Wide Screening on S. pombe Deletion Library
Q47093593Impairment of Mitochondrial Biogenesis and Dynamics Involved in Isoniazid-Induced Apoptosis of HepG2 Cells Was Alleviated by p38 MAPK Pathway
Q42485953In-depth physiological characterization of primary human hepatocytes in a 3D hollow-fiber bioreactor.
Q28552676Inflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- Mice
Q90723016Limonin: A Review of Its Pharmacology, Toxicity, and Pharmacokinetics
Q52610392Major role of apolipoprotein B in cycloheximide-induced acute hepatic steatosis in mice.
Q35956406Mammalian Cells Exhibit a Range of Sensitivities to Silver Nanoparticles that are Partially Explicable by Variations in Antioxidant Defense and Metallothionein Expression
Q37557613Mechanism-based bioanalysis and biomarkers for hepatic chemical stress.
Q33856306Mechanisms of immune-mediated liver injury
Q38208324Mechanisms of isoniazid-induced idiosyncratic liver injury: emerging role of mitochondrial stress
Q26864710Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity
Q33954265Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria
Q90152339Metabolic Comorbidities and Risk of Development and Severity of Drug-Induced Liver Injury
Q38675826Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.
Q38084631Mitochondria as a pharmacological target: magnum overview
Q92619453Mitochondrial DNA Variants in Patients with Liver Injury Due to Anti-Tuberculosis Drugs
Q50049868Mitochondrial dysfunction induced by leflunomide and its active metabolite
Q42720801Mitochondrial dysfunction induced by sertraline, an antidepressant agent
Q42215667Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes unveiled by valproate
Q42959618Nonalcoholic steatohepatitis in a patient with ataxia-telangiectasia
Q57119333Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures
Q36051438Oxidative Stress and Liver Morphology in Experimental Cyclosporine A-Induced Hepatotoxicity.
Q42090708PharmGKB summary: isoniazid pathway, pharmacokinetics.
Q64389174Pharmacometabolomics Reveals Irinotecan Mechanism of Action in Cancer Patients
Q36247086Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria
Q42054933Protective effects of an ethanol extract of Angelica keiskei against acetaminophen-induced hepatotoxicity in HepG2 and HepaRG cells
Q51133492Protective role of thymoquinone against liver damage induced by tamoxifen in female rats.
Q36119623Red Palm Oil Attenuates Lead Acetate Induced Testicular Damage in Adult Male Sprague-Dawley Rats
Q93197421Role of Kupffer cells in liver injury induced by CpG oligodeoxynucleotide and flucloxacillin in mice
Q26765518Role of endoplasmic reticulum stress in drug-induced toxicity
Q38687132Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity
Q38268013SEURAT-1 liver gold reference compounds: a mechanism-based review
Q37529605Screening for the drug-phospholipid interaction: correlation to phospholipidosis
Q37802944Strategies for the early detection of drug-induced hepatic steatosis in preclinical drug safety evaluation studies
Q57067352Subchronic Toxicity Studies of Cortex Dictamni Extracts in Mice and Its Potential Hepatotoxicity Mechanisms in Vitro
Q36502027Tamoxifen induces hepatotoxicity and changes to hepatocyte morphology at the early stage of endocrinotherapy in mice
Q42359107Targeted transplantation of mitochondria to hepatocytes
Q92241354The Beneficial Roles of SIRT1 in Drug-Induced Liver Injury
Q44397464The antiestrogen 4-hydroxytamoxifen protects against isotretinoin-induced permeability transition and bioenergetic dysfunction of liver mitochondria: comparison with tamoxifen.
Q44060851The combination of glutamate receptor antagonist MK-801 with tamoxifen and its active metabolites potentiates their antiproliferative activity in mouse melanoma K1735-M2 cells.
Q46272510Tools to Measure Cell Health and Cytotoxicity Using High Content Imaging and Analysis
Q52981626Toxicity of Evodiae fructus on rat liver mitochondria: the role of oxidative stress and mitochondrial permeability transition.
Q99201941Treatments in Covid-19 patients with pre-existing metabolic dysfunction-associated fatty liver disease: A potential threat for drug-induced liver injury?
Q36195072Zolpidem Use Associated With Increased Risk of Pyogenic Liver Abscess: A Case-Control Study in Taiwan

Search more.