Enhanced oxidative stress and increased mitochondrial mass during efavirenz-induced apoptosis in human hepatic cells

scientific article

Enhanced oxidative stress and increased mitochondrial mass during efavirenz-induced apoptosis in human hepatic cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1476-5381.2010.00866.X
P932PMC publication ID2958650
P698PubMed publication ID20649602
P5875ResearchGate publication ID45280677

P50authorNadezda ApostolovaQ43661087
P2093author name stringJ V Esplugues
A Alvarez
A Blas-Garcia
A Moran
L J Gomez-Sucerquia
P2860cites workRapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysQ25939005
Genomic Analysis Reveals a Potential Role for Cell Cycle Perturbation in HCV-Mediated Apoptosis of Cultured HepatocytesQ27487541
Cell death: critical control pointsQ28240722
Caspases 3 and 7: key mediators of mitochondrial events of apoptosisQ28588439
Free radicals, metals and antioxidants in oxidative stress-induced cancerQ29547711
Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteriaQ29616614
Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patientsQ31977562
Growing tissue-like constructs with Hep3B/HepG2 liver cells on PHBV microspheres of different sizesQ33260035
Evaluation of fluorescent dyes for measuring intracellular glutathione content in primary cultures of human neurons and neuroblastoma SH-SY5Y.Q34166941
Prediction of neuropsychiatric adverse events associated with long-term efavirenz therapy, using plasma drug level monitoringQ34464997
Selective fluorescent imaging of superoxide in vivo using ethidium-based probesQ35062293
Toxicity of non-nucleoside analogue reverse transcriptase inhibitorsQ35151048
Interpatient variability in the pharmacokinetics of the HIV non-nucleoside reverse transcriptase inhibitor efavirenz: the effect of gender, race, and CYP2B6 polymorphismQ35827416
Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress.Q36032328
Hepatotoxicity of antiretroviral drugsQ36321070
Central role of mitochondria in metabolic regulation of liver pathophysiologyQ36849033
Cellular and molecular mechanisms of liver injuryQ36908855
Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitusQ37215415
Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panelQ37234205
Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studiesQ37244314
Caspases in apoptosis and beyondQ37302731
Induction of apoptosis by a nonnucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitorQ39652630
Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesisQ39867349
Enhanced oxidative stress and aberrant mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells during methamphetamine induced apoptosis.Q40160898
Reverse transcriptase inhibitors down-regulate cell proliferation in vitro and in vivo and restore thyrotropin signaling and iodine uptake in human thyroid anaplastic carcinoma.Q40395729
Mitochondrial proliferation during apoptosis induced by anticancer agents: effects of doxorubicin and mitoxantrone on cancer and cardiac cells.Q40531832
Increased long-term mitochondrial toxicity in combinations of nucleoside analogue reverse-transcriptase inhibitorsQ40693184
Resveratrol induces colon tumor cell apoptosis independently of p53 and precede by epithelial differentiation, mitochondrial proliferation and membrane potential collapseQ40763086
Flow cytometric measurement of mitochondrial mass and function: a novel method for assessing chemoresistanceQ41038244
The specificity of neuroprotection by antioxidantsQ42647233
Hepatotoxicity in patients prescribed efavirenz or nevirapine.Q42980795
Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cellsQ43011656
Penetration of efavirenz into the male genital tract: drug concentrations and antiviral activity in semen and blood of HIV-1-infected men.Q43766805
Hepatotoxicity associated with nevirapine or efavirenz-containing antiretroviral therapy: role of hepatitis C and B infectionsQ43851688
Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults. Study 006 TeamQ44088437
Lipid changes in patients initiating efavirenz- and indinavir-based antiretroviral regimensQ44309075
A paediatric case of acute liver failure associated with efavirenz-based highly active antiretroviral therapy and effective use of raltegravir in combination antiretroviral treatment after liver transplantationQ44556634
An extremely different dysmetabolic profile between the two available nonnucleoside reverse transcriptase inhibitors: efavirenz and nevirapineQ45239039
Combination therapy with efavirenz, nelfinavir, and nucleoside reverse-transcriptase inhibitors in children infected with human immunodeficiency virus type 1. Pediatric AIDS Clinical Trials Group 382 TeamQ45745660
Are adverse events of nevirapine and efavirenz related to plasma concentrations?Q46614058
Oxidative stress-induced apoptosis prevented by TroloxQ72150904
Human hepatocyte cultureQ83830231
P4510describes a project that usesImageQuantQ112270642
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectefavirenzQ422645
apoptotic processQ14599311
P304page(s)2069-2084
P577publication date2010-08-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleEnhanced oxidative stress and increased mitochondrial mass during efavirenz-induced apoptosis in human hepatic cells
P478volume160

Reverse relations

cites work (P2860)
Q94601929Anti-HIV drugs promote β-amyloid deposition and impair learning and memory in BALB/c mice
Q38954255Antileishmanial activity of antiretroviral drugs combined with miltefosine.
Q33784656Antiretroviral therapy-induced mitochondrial toxicity: potential mechanisms beyond polymerase-γ inhibition
Q57299773Apoptosis inducing factor deficiency causes retinal photoreceptor degeneration. The protective role of the redox compound methylene blue
Q35007676Association of circulating cytochrome c with clinical manifestations of antiretroviral-induced toxicity
Q47141835Autophagy in drug-induced liver toxicity
Q37926590Central role of mitochondria in drug-induced liver injury
Q37460217Cited2 is required for the maintenance of glycolytic metabolism in adult hematopoietic stem cells
Q90253728Combination of Tenofovir and Emtricitabine with Efavirenz Does Not Moderate Inhibitory Effect of Efavirenz on Mitochondrial Function and Cholesterol Biosynthesis in Human T Lymphoblastoid Cell Line
Q43558721Compromising mitochondrial function with the antiretroviral drug efavirenz induces cell survival-promoting autophagy
Q49726714Cytotoxic effect of Efavirenz in BxPC-3 pancreatic cancer cells is based on oxidative stress and is synergistic with ionizing radiation.
Q35076879Cytotoxicity of lidocaine to human corneal endothelial cells in vitro
Q36442232Development and evaluation of a thermosensitive vaginal gel containing raltegravir+efavirenz loaded nanoparticles for HIV prophylaxis
Q37139458EFV/FTC/TDF-associated hepatotoxicity: a case report and review
Q28548473Efavirenz Has the Highest Anti-Proliferative Effect of Non-Nucleoside Reverse Transcriptase Inhibitors against Pancreatic Cancer Cells
Q28085028Efavirenz and the CNS: what we already know and questions that need to be answered
Q40386326Effect of the Anti-retroviral Drugs Efavirenz, Tenofovir and Emtricitabine on Endothelial Cell Function: Role of PARP.
Q92887670Effects of quercetin on bisphenol A-induced mitochondrial toxicity in rat liver
Q38193602Endoplasmic reticulum stress in drug- and environmental toxicant-induced liver toxicity
Q58549748Examining Relationships between Metabolism and Persistent Inflammation in HIV Patients on Antiretroviral Therapy
Q36368683HIV nonnucleoside reverse transcriptase inhibitors and trimethoprim-sulfamethoxazole inhibit plasmodium liver stages
Q28729025HIV-1 infection and first line ART induced differential responses in mitochondria from blood lymphocytes and monocytes: the ANRS EP45 "Aging" study
Q41935715HIV/HAART-associated oxidative stress is detectable by metabonomics
Q38722124Harmonization of Mangiferin on methylmercury engendered mitochondrial dysfunction.
Q56829831High plasma efavirenz level and CYP2B6*6 are associated with efavirenz-based HAART-induced liver injury in the treatment of naïve HIV patients from Ethiopia: a prospective cohort study
Q58680687High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins
Q38383132High-content screening technology for studying drug-induced hepatotoxicity in cell models.
Q36868348Human leukocyte/endothelial cell interactions and mitochondrial dysfunction in type 2 diabetic patients and their association with silent myocardial ischemia.
Q38645161In vitro and Ex vivo Neurotoxic Effects of Efavirenz are Greater than Those of Other Common Antiretrovirals.
Q90231170In vitro antioxidant efficacy and the therapeutic potential of Wendlandia heynei (Schult.) Santapau & Merchant against bisphenol A-induced hepatotoxicity in rats
Q46250998Increased MMAB level in mitochondria as a novel biomarker of hepatotoxicity induced by Efavirenz
Q30393445Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells
Q38695833Inhibition of Plasmodium Hepatic Infection by Antiretroviral Compounds
Q36063046Intracellular expression of Tat alters mitochondrial functions in T cells: a potential mechanism to understand mitochondrial damage during HIV-1 replication
Q38976612Lack of mitochondrial toxicity of darunavir, raltegravir and rilpivirine in neurons and hepatocytes: a comparison with efavirenz
Q47757120Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress.
Q35045143Mechanisms of cell death pathway activation following drug-induced inhibition of mitochondrial complex I.
Q38208324Mechanisms of isoniazid-induced idiosyncratic liver injury: emerging role of mitochondrial stress
Q35223924Mitochondrial (dys)function - a factor underlying the variability of efavirenz-induced hepatotoxicity?
Q39295078Mitochondrial accumulation under oxidative stress is due to defects in autophagy.
Q36306214Mitochondrial alteration in malignantly transformed human small airway epithelial cells induced by α-particles
Q42700407Mitochondrial dysfunction induced by Bisphenol A is a factor of its hepatotoxicity in rats
Q93050517NNRTI-induced HIV-1 protease-mediated cytotoxicity induces rapid death of CD4 T cells during productive infection and latency reversal
Q42090708PharmGKB summary: isoniazid pathway, pharmacokinetics.
Q28478275Pharmacogenetic & pharmacokinetic biomarker for efavirenz based ARV and rifampicin based anti-TB drug induced liver injury in TB-HIV infected patients
Q46257896Reactive oxygen species modulate itraconazole-induced apoptosis via mitochondrial disruption in Candida albicans
Q36663879Risk Factors for Incident Diabetes in a Cohort Taking First-Line Nonnucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy
Q36283681Robust glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI family member protein, is critical for oxidative stress resistance in Saccharomyces cerevisiae
Q26765518Role of endoplasmic reticulum stress in drug-induced toxicity
Q37077573Role of mitochondria in HIV infection and associated metabolic disorders: focus on nonalcoholic fatty liver disease and lipodystrophy syndrome.
Q47392916Role of p62/SQSTM1 beyond autophagy: a lesson learned from drug-induced toxicity in vitro
Q35615469Suppression of Human T Cell Proliferation Mediated by the Cathepsin B Inhibitor, z-FA-FMK Is Due to Oxidative Stress
Q46271945The cathepsin B inhibitor z-FA-CMK induces cell death in leukemic T cells via oxidative stress
Q38955273The interplay between apoptosis, mitophagy and mitochondrial biogenesis induced by resveratrol can determine activated hepatic stellate cells death or survival
Q45732791Toxicological study and oxidative stress evaluation for safety assessment of xylanase preparations in Wistar rats
Q39034431Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies.
Q35206515bFGF attenuates endoplasmic reticulum stress and mitochondrial injury on myocardial ischaemia/reperfusion via activation of PI3K/Akt/ERK1/2 pathway

Search more.