In vitro and Ex vivo Neurotoxic Effects of Efavirenz are Greater than Those of Other Common Antiretrovirals.

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In vitro and Ex vivo Neurotoxic Effects of Efavirenz are Greater than Those of Other Common Antiretrovirals. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1090944576
P356DOI10.1007/S11064-017-2358-X
P698PubMed publication ID28770436

P50authorIris SpeigelQ83420073
P2093author name stringPaul S García
William R Tyor
Vincent T Ciavatta
Edyta K Bichler
Courtney C Elder
Shavonne L Teng
P2860cites workDevelopmental and regional expression in the rat brain and functional properties of four NMDA receptorsQ28570615
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Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenzQ36406259
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Efavirenz alters mitochondrial respiratory function in cultured neuron and glial cell linesQ38880828
Neuronal bioenergetics and acute mitochondrial dysfunction: a clue to understanding the central nervous system side effects of efavirenzQ38996720
Interferon-α induces neurotoxicity through activation of the type I receptor and the GluN2A subunit of the NMDA receptorQ39396414
CH05-10, a novel indinavir analog, is a broad-spectrum antitumor agent that induces cell cycle arrest, apoptosis, endoplasmic reticulum stress and autophagy.Q39644230
Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell lineQ40198849
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Central nervous system penetration of antiretroviral drugs: pharmacokinetic, pharmacodynamic and pharmacogenomic considerationsQ41208022
Combined antiretroviral therapy reduces brain viral load and pathological features of HIV encephalitis in a mouse model.Q42243855
Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cellsQ43011656
Sensory neuropathy in human immunodeficiency virus/acquired immunodeficiency syndrome patients: protease inhibitor-mediated neurotoxicityQ45417353
Meeting practical challenges of a trial involving a multitude of treatment regimens: an example of a multi-center randomized controlled clinical trial in neuroAIDS.Q46111007
Highly active antiretroviral therapy and human immunodeficiency virus encephalitisQ46456152
Antiretroviral drugs and the central nervous systemQ48350664
Intrinsic excitability of CA1 pyramidal neurones from the rat dorsal and ventral hippocampusQ48372373
Measurement of mitochondrial oxygen consumption rates in mouse primary neurons and astrocytesQ48488075
Nevirapine versus efavirenz based antiretroviral treatment in naive Indian patients: comparison of effectiveness in clinical cohortQ79861399
The relationship of CPE to HIV dementia: slain by an ugly fact?Q88035349
P433issue11
P921main subjectefavirenzQ422645
neurotoxicityQ3338704
anti-retroviral agentQ50430310
P304page(s)3220-3232
P577publication date2017-08-02
P1433published inNeurochemical ResearchQ15716728
P1476titleIn vitro and Ex vivo Neurotoxic Effects of Efavirenz are Greater than Those of Other Common Antiretrovirals
P478volume42

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cites work (P2860)
Q57310566Effects of HIV Infection, methamphetamine dependence and age on cortical thickness, area and volume
Q90071250Evaluating Neurodevelopmental Consequences of Perinatal Exposure to Antiretroviral Drugs: Current Challenges and New Approaches
Q92158622HIV-1 infection alters energy metabolism in the brain: Contributions to HIV-associated neurocognitive disorders
Q93168370Interactive effects of HIV and ageing on neural oscillations: independence from neuropsychological performance
Q90108881Neuroinflammation & pre-mature aging in the context of chronic HIV infection and drug abuse: Role of dysregulated autophagy

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