Efavirenz alters mitochondrial respiratory function in cultured neuron and glial cell lines

scientific article published on 29 April 2015

Efavirenz alters mitochondrial respiratory function in cultured neuron and glial cell lines is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/JAC/DKV098
P8608Fatcat IDrelease_obvu7edj75c5zgcnlzq73esazi
P698PubMed publication ID25925594

P2093author name stringJuan V Esplugues
Nadezda Apostolova
Ana Blas-Garcia
Haryes A Funes
P2860cites workHypometabolism as a therapeutic target in Alzheimer's diseaseQ21262020
Efavirenz promotes β-secretase expression and increased Aβ1-40,42 via oxidative stress and reduced microglial phagocytosis: implications for HIV associated neurocognitive disorders (HAND).Q31159582
Bioenergetic characterization of mouse podocytesQ34085737
Assessing mitochondrial dysfunction in cells.Q34793639
Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related diseaseQ34801664
The acute extracellular flux (XF) assay to assess compound effects on mitochondrial functionQ35405000
Protein-free efavirenz concentrations in cerebrospinal fluid and blood plasma are equivalent: applying the law of mass action to predict protein-free drug concentrationQ36667153
Neuropsychiatric side effects of efavirenz therapyQ36762436
Advances in measuring cellular bioenergetics using extracellular fluxQ37110791
Implications of efavirenz for neuropsychiatry: a review.Q37801927
Involvement of nitric oxide in the mitochondrial action of efavirenz: a differential effect on neurons and glial cells.Q38925613
Neuronal bioenergetics and acute mitochondrial dysfunction: a clue to understanding the central nervous system side effects of efavirenzQ38996720
Cell surface oxygen consumption: a major contributor to cellular oxygen consumption in glycolytic cancer cell linesQ40176788
The antiretroviral protease inhibitors indinavir and nelfinavir stimulate Mrp1-mediated GSH export from cultured brain astrocytesQ44176745
Energy thresholds in brain mitochondria. Potential involvement in neurodegeneration.Q48462986
Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms.Q52741772
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectefavirenzQ422645
P304page(s)2249-2254
P577publication date2015-04-29
P1433published inJournal of Antimicrobial ChemotherapyQ6294770
P1476titleEfavirenz alters mitochondrial respiratory function in cultured neuron and glial cell lines
P478volume70

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cites work (P2860)
Q38628801An Overview of Human Immunodeficiency Virus Type 1-Associated Common Neurological Complications: Does Aging Pose a Challenge?
Q37691000Antiretroviral Treatment in HIV-1-Positive Mothers: Neurological Implications in Virus-Free Children
Q40051820Central nervous system-penetrating antiretrovirals impair energetic reserve in striatal nerve terminals
Q92150931Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice
Q90253728Combination of Tenofovir and Emtricitabine with Efavirenz Does Not Moderate Inhibitory Effect of Efavirenz on Mitochondrial Function and Cholesterol Biosynthesis in Human T Lymphoblastoid Cell Line
Q39364925Consequences of a Chronic Exposure of Cultured Brain Astrocytes to the Anti-Retroviral Drug Efavirenz and its Primary Metabolite 8-Hydroxy Efavirenz.
Q89398971Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy
Q92570343Improved Central Nervous System Symptoms in People with HIV without Objective Neuropsychiatric Complaints Switching from Efavirenz to Rilpivirine Containing cART
Q38645161In vitro and Ex vivo Neurotoxic Effects of Efavirenz are Greater than Those of Other Common Antiretrovirals.
Q59355519Nanoformulated Antiretroviral Therapy Attenuates Brain Metabolic Oxidative Stress
Q36330202Neurobehavioral Manifestations of Human Immunodeficiency Virus/AIDS: Diagnosis and Treatment
Q61797159Neurodevelopmental and behavioral consequences of perinatal exposure to the HIV drug efavirenz in a rodent model
Q92135854Neuropsychiatric and Neurocognitive Manifestations in HIV-Infected Children Treated With Efavirenz in South Africa-A Retrospective Case Series
Q38882614Neurotoxicity in the Post-HAART Era: Caution for the Antiretroviral Therapeutics
Q90140528The far-reaching HAND of cART: cART effects on astrocytes

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