Maturation and emigration of single-positive thymocytes

scientific article published on 29 September 2013

Maturation and emigration of single-positive thymocytes is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2013/282870
P932PMC publication ID3804360
P698PubMed publication ID24187562
P5875ResearchGate publication ID258255415

P2093author name stringQing Ge
Xi Xu
Jin Lu
Pingping Li
Qun Xuan
Shusong Zhang
P2860cites workHomeostatic signals do not drive post-thymic T cell maturationQ42078076
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Microvasculature of normal and involuted mouse thymus. Light- and electron-microscopic studyQ42498855
An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domainsQ24313206
Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunityQ24643886
Deletional tolerance mediated by extrathymic Aire-expressing cellsQ24652952
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4Q24670840
Cellular and molecular determinants for the development of natural and induced regulatory T cellsQ26853475
The thymic medulla: a unique microenvironment for intercellular self-antigen transferQ42572856
CCR7 signals are essential for cortex-medulla migration of developing thymocytes.Q42971212
Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodentsQ43610489
Thymocyte Sensitivity and Supramolecular Activation Cluster Formation Are Developmentally Regulated: A Partial Role for SialylationQ44625252
Induction of high level IL-2 production in CD4+8- T helper lymphocytes requires post-thymic developmentQ45143053
Autophagy is essential for mitochondrial clearance in mature T lymphocytesQ45162920
The majority of CD4+8- thymocytes are functionally immatureQ45196734
Processing and presentation of HLA class I and II epitopes by dendritic cells after transfection with in vitro-transcribed MUC1 RNA.Q45200866
Phosphatidylinositol 3-kinase regulates thymic exitQ46095509
Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradientsQ46265539
Programmed death-1 is required for systemic self-tolerance in newly generated T cells during the establishment of immune homeostasisQ46624018
CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epitheliumQ46624087
Role of the aryl hydrocarbon receptor in thymocyte emigration in vivoQ46662081
CD69 down-modulation and inhibition of thymic egress by short- and long-term selective chemical agonism of sphingosine 1-phosphate receptorsQ46846172
CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central toleranceQ46941016
Developmentally distinct Th cells control plasma cell production in vivoQ47194599
Mature human thymocytes migrate on laminin-5 with activation of metalloproteinase-14 and cleavage of CD44.Q47252412
Impaired migration of NOD mouse thymocytes: a fibronectin receptor-related defectQ47431193
Continued maturation of thymic emigrants in the peripheryQ48022294
Thymic microenvironments for T-cell repertoire formationQ37360649
CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigensQ37386006
MHC drives TCR repertoire shaping, but not maturation, in recent thymic emigrantsQ37436190
The impact of negative selection on thymocyte migration in the medulla.Q37476326
Antigen presentation in the thymus for positive selection and central tolerance inductionQ37638193
Dysregulation of Thymic Clonal Deletion and the Escape of Autoreactive T CellsQ37792913
Th17 cell development: from the cradle to the graveQ38081169
The mechanism of tissue-restricted antigen gene expression by AIRE.Q38086140
Intrathymic and Extrathymic T Cell MaturationQ39230335
CCL25 mediates the localization of recently activated CD8alphabeta(+) lymphocytes to the small-intestinal mucosaQ39737286
Endogenous presentation of a nuclear antigen on MHC class II by autophagy in the absence of CRM1-mediated nuclear exportQ39961894
Intercellular MHC transfer between thymic epithelial and dendritic cellsQ39992060
Endogenous MHC class II processing of a viral nuclear antigen after autophagy.Q40481959
Lymphotoxin pathway directs thymic Aire expressionQ40630236
Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagyQ40649977
Excessive degradation of intracellular protein in macrophages prevents presentation in the context of major histocompatibility complex class II moleculesQ41107379
Turnover of naive- and memory-phenotype T cellsQ41475935
T cells require Foxo1 to populate the peripheral lymphoid organsQ41486256
Restoration of T-cell homeostasis after T-cell depletionQ41665917
Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammationQ41889460
The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses.Q50890356
Development of TCRB CDR3 length repertoire of human T lymphocytes.Q51025029
Characterization of the in vivo dynamics of medullary CD4+CD8- thymocyte development.Q51965107
NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner.Q52093900
Two developmentally distinct populations of dendritic cells inhabit the adult mouse thymus: demonstration by differential importation of hematogenous precursors under steady state conditions.Q52107789
Subpopulations of mature murine thymocytes: properties of CD4-CD8+ and CD4+CD8- thymocytes lacking the heat-stable antigen.Q52120543
Comparison of CDR3 length among thymocyte subpopulations: impacts of MHC and BV segment on the CDR3 shortening.Q53584018
Control of recent thymic emigrant survival by positive selection signals and early growth response gene 1.Q53663075
Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo.Q54000307
Characterization of the extracellular matrix-containing giant perivascular spaces in the NOD mouse thymus.Q54254669
Rapid migration of thymic emigrants to the colonic mucosa in ulcerative colitis patientsQ54411454
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.Q55035366
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for toleranceQ56701390
Thymic emigrants isolated by a new method possess unique phenotypic and functional propertiesQ56905330
Reactive Oxygen Species Regulate Activation-Induced T Cell ApoptosisQ56922123
RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouseQ57161977
Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortexQ59071991
Recent thymic emigrants are distinct from most medullary thymocytesQ62230549
Immunosuppressant FTY720 inhibits thymocyte emigrationQ63965617
Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenovirusesQ64382382
Qa-2 expression in the adult murine thymus. A unique marker for a mature thymic subsetQ69481428
Analysis of recent thymic emigrants with subset- and maturity-related markersQ70264823
CD45 up-regulation during lymphocyte maturationQ71834277
Production, selection, and maturation of thymocytes with high surface density of TCRQ72527019
CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selectionQ72658265
Three-dimensional ultrastructure of the perivascular space in the rat thymusQ73361840
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptideQ73688337
Phenotypic identification of the subgroups of murine T-cell receptor alphabeta+ CD4+ CD8- thymocytes and its implication in the late stage of thymocyte developmentQ78157778
Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcriptionQ80427894
Lack of reactive oxygen species breaks T cell tolerance to collagen type II and allows development of arthritis in miceQ80641623
The regulated expression of a diverse set of genes during thymocyte positive selection in vivoQ80884490
Influx of recent thymic emigrants into autoimmune thyroid disease glands in humansQ81661426
Crucial contribution of thymic Sirp alpha+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent mannerQ84394189
Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selectionQ27666863
Positional cloning of the APECED geneQ28116470
The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9Q28140646
Aire deficient mice develop multiple features of APECED phenotype and show altered immune responseQ28202432
Projection of an immunological self shadow within the thymus by the aire proteinQ28207164
Aire regulates negative selection of organ-specific T cellsQ28213185
Kruppel-like factor 2 regulates thymocyte and T-cell migrationQ28253004
Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptorsQ28268052
miR-181a is an intrinsic modulator of T cell sensitivity and selectionQ28294631
Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytesQ28512316
Dependence of self-tolerance on TRAF6-directed development of thymic stromaQ28590193
Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigrationQ28592508
Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central toleranceQ28593303
Expression of relB is required for the development of thymic medulla and dendritic cellsQ28594949
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1Q29619644
Heterogeneity within medullary-type TCRalphabeta(+)CD3(+)CD4(-)CD8(+) thymocytes in normal mouse thymusQ32061851
Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant.Q33188469
Vascular endothelium as a contributor of plasma sphingosine 1-phosphateQ33378571
The central effectors of cell death in the immune systemQ33652530
Maturation-dependent licensing of naive T cells for rapid TNF productionQ33760914
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte traffickingQ33800990
Thymic emigration: when and how T cells leave homeQ33817100
Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin.Q33839955
Different contributions of thymopoiesis and homeostasis-driven proliferation to the reconstitution of naive and memory T cell compartmentsQ34015733
The molecular signature underlying the thymic migration and maturation of TCRαβ+ CD4+ CD8 thymocytesQ34055641
Pericapillary collagen in the human thymus: implications for the concept of the 'blood-thymus' barrierQ34086746
Control of central and peripheral tolerance by AireQ34177944
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel familyQ34317095
Clues to immune tolerance: the monogenic autoimmune syndromesQ34440616
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell developmentQ34577749
Homeostatic properties and phenotypic maturation of murine CD4+ pre-thymic emigrants in the thymusQ34586912
Self-antigen presentation by dendritic cells and lymphoid stroma and its implications for autoimmunityQ34590424
The impact of circulating dendritic cells on the development and differentiation of thymocytesQ34601204
Recent thymic emigrants are biased against the T-helper type 1 and toward the T-helper type 2 effector lineageQ34666914
Thymic output in aged miceQ34694301
Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junctionQ35022130
NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathwayQ35070399
Lipid phosphate phosphatase 3 enables efficient thymic egressQ35213578
NKAP is required for T cell maturation and acquisition of functional competencyQ35213582
Post-thymic maturation: young T cells assert their individualityQ35620794
Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central toleranceQ35861549
Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonistQ35978652
Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation thresholdQ35982959
Molecular genetics of T cell developmentQ36072446
Developmental pathway of CD4+CD8- medullary thymocytes during mouse ontogeny and its defect in Aire-/- miceQ36156870
Heterogeneity of thymic dendritic cellsQ36157476
Linking signalling pathways, thymic stroma integrity and autoimmunityQ36204784
Thymic emigration revisitedQ36229138
Murine thymic CD4+ T cell subsets: a subset (Thy0) that secretes diverse cytokines and overexpresses the V beta 8 T cell receptor gene familyQ36231469
Autoimmune polyendocrinopathy syndrome type 1 (APS1) and AIRE gene: new views on molecular basis of autoimmunityQ36313770
Autocrine production of extracellular catalase prevents apoptosis of the human CEM T-cell line in serum-free mediumQ36315481
Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR.Q36371648
The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte poolQ36400977
CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidityQ36401360
Journey through the thymus: stromal guides for T-cell development and selectionQ36402237
A central role for central toleranceQ36427372
A central role for thymic emigrants in peripheral T cell homeostasisQ36433740
Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virusQ36509892
Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.Q36603522
Thymic output: influence factors and molecular mechanismQ36648117
T-cell potential and development in vitro: the OP9-DL1 approachQ36736613
The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte developmentQ36750060
PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medullaQ37041684
Effector CD8 T cell development: a balancing act between memory cell potential and terminal differentiationQ37061697
Postthymic maturation influences the CD8 T cell response to antigen.Q37140129
Cutting edge: Contact with secondary lymphoid organs drives postthymic T cell maturationQ37185833
Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymusQ37234298
The thymus medulla slowly yields its secrets.Q37348444
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectcellQ7868
cell motilityQ14873676
cell differentiationQ210861
thymocyteQ7799635
bone marrow cellsQ66004840
P304page(s)282870
P577publication date2013-09-29
P1433published inClinical and Developmental ImmunologyQ15754140
P1476titleMaturation and emigration of single-positive thymocytes
P478volume2013

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