| scholarly article | Q13442814 |
| P356 | DOI | 10.1021/JA3125417 |
| P8608 | Fatcat ID | release_vwct3hzlcjdkjhmj7tavwkp54i |
| P932 | PMC publication ID | 3806051 |
| P698 | PubMed publication ID | 23641733 |
| P5875 | ResearchGate publication ID | 236635851 |
| P50 | author | Jeffrey R. Deschamps | Q37371382 |
| P2093 | author name string | Wei Sun | |
| Denzil Bernard | |||
| Liu Liu | |||
| Shaomeng Wang | |||
| Xiaoqin Li | |||
| Yujun Zhao | |||
| Duxin Sun | |||
| Donna McEachern | |||
| Jianfeng Lu | |||
| Jean-Christophe Carry | |||
| Philippe Ochsenbein | |||
| Shanghai Yu | |||
| Vincent Ferey | |||
| P2860 | cites work | Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products | Q39664659 |
| Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction. | Q40270647 | ||
| Organocatalytic synthesis of spiro[pyrrolidin-3,3'-oxindoles] with high enantiopurity and structural diversity. | Q43279699 | ||
| Pteropodine and isopteropodine positively modulate the function of rat muscarinic M(1) and 5-HT(2) receptors expressed in Xenopus oocyte | Q44111191 | ||
| Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization. | Q45027288 | ||
| Structure-based design of potent non-peptide MDM2 inhibitors | Q46608003 | ||
| Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53 | Q74247134 | ||
| THE STRUCTURE AND STEREOISOMERISM OF THREE MITRAGYNA ALKALOIDS | Q105103548 | ||
| In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 | Q27642888 | ||
| Structure-based design of novel inhibitors of the MDM2-p53 interaction | Q27678657 | ||
| A library of spirooxindoles based on a stereoselective three-component coupling reaction. | Q31134582 | ||
| A Rapid Total Synthesis of Spirotryprostatin B: Proof of Its Relative and Absolute Stereochemistry F.v.N. gratefully acknowledges the Alexander-von-Humboldt-Stiftung for a Feodor-Lynen fellowship that was kindly backed by Dr. R. Breslow as second ho | Q33913633 | ||
| Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition | Q36499146 | ||
| Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents | Q36974491 | ||
| Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction | Q37483244 | ||
| P433 | issue | 19 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 7223-7234 | |
| P577 | publication date | 2013-05-03 | |
| P1433 | published in | Journal of the American Chemical Society | Q898902 |
| P1476 | title | Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors | |
| P478 | volume | 135 |
| Q37432745 | A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice. |
| Q37620132 | Additive-assisted regioselective 1,3-dipolar cycloaddition of azomethine ylides with benzylideneacetone |
| Q26747255 | Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update |
| Q48254967 | Catalytic enantioselective cascade Michael/cyclization reaction of 3-isothiocyanato oxindoles with exocyclic α,β-unsaturated ketones en route to 3,2'-pyrrolidinyl bispirooxindoles |
| Q50228671 | Cerium oxide-catalyzed multicomponent condensation approach to spirooxindoles in water |
| Q26749008 | Chemical Variations on the p53 Reactivation Theme |
| Q45930139 | Counterion effects in the catalytic stereoselective synthesis of 2,3'-pyrrolidinyl spirooxindoles. |
| Q42099865 | Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles. |
| Q39608263 | Development of a novel immunoassay to detect interactions with the transactivation domain of p53: application to screening of new drugs |
| Q30670705 | Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions†Electronic supplementary information (ESI) available: Experimental details for compound synthesis, analytical data for all compounds and in |
| Q33572704 | Discovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine [...] |
| Q27684218 | Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development |
| Q28550874 | Energetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 Interaction |
| Q38865504 | Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction. |
| Q50074454 | Organocatalytic [3 + 2] cycloaddition of oxindole-based azomethine ylides with 3-nitrochromenes: a facile approach to enantioenriched polycyclic spirooxindole-chromane adducts |
| Q64106699 | Protoporphyrin IX is a dual inhibitor of p53/MDM2 and p53/MDM4 interactions and induces apoptosis in B-cell chronic lymphocytic leukemia cells |
| Q38238600 | Resistance acquisition to MDM2 inhibitors. |
| Q39205536 | Reviving the guardian of the genome: Small molecule activators of p53. |
| Q34584722 | SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression |
| Q35411745 | Searching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach |
| Q90328524 | Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders |
| Q54992503 | Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets. |
| Q35617077 | Small-molecule MDM2-p53 inhibitors: recent advances |
| Q38181445 | Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system |
| Q92485714 | Synthesis of DNA-coupled isoquinolones and pyrrolidines by solid phase ytterbium- and silver-mediated imine chemistry |
| Q93240867 | Targeted Synthesis of Complex Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2-p53 Inhibitors |
| Q35030217 | Targeting MDM2-p53 interaction for cancer therapy: are we there yet? |
| Q47337952 | Targeting oncoproteins for degradation by small molecules in myeloid leukemia. |
| Q38749151 | Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapy: Progress and Challenges. |
| Q43078018 | Titanium(IV)-catalyzed stereoselective synthesis of spirooxindole-1-pyrrolines |
| Q27680560 | Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction |
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