Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women

scientific article published on 10 June 2009

Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3945/AJCN.2009.27747
P932PMC publication ID2709310
P698PubMed publication ID19515736
P5875ResearchGate publication ID26281935

P50authorJesse F. GregoryQ41844201
Yvonne LamersQ43146345
P2093author name stringPeter W Stacpoole
Dwight E Matthews
Christine Keeling
Lesa R Gilbert
Bruce O'Rourke
P2860cites workA simultaneous liquid chromatography/mass spectrometric assay of glutathione, cysteine, homocysteine and their disulfides in biological samplesQ44332538
Low Vitamin B6 but Not Homocyst(e)ine Is Associated With Increased Risk of Stroke and Transient Ischemic Attack in the Era of Folic Acid Grain FortificationQ44435312
Quantitative study in vivo of methionine cycle in humans using [methyl-2H3]- and [1-13C]methionineQ44494347
Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donorQ44618189
Oxidant/antioxidant status in liver tissue of vitamin B6 deficient ratsQ46492669
Red blood cells as a physiological source of glutathione for extracellular fluidsQ46928710
Low plasma vitamin B-6 concentrations and modulation of coronary artery disease riskQ47438621
Rat brain glutathione and pyridoxine deficiency.Q51312098
Effect of cysteine dosage on erythrocyte glutathione synthesis rate in a patient with cystathionine beta synthase deficiency.Q51718358
Plasma glutathione and cystathionine concentrations are elevated but cysteine flux is unchanged by dietary vitamin B-6 restriction in young men and women.Q51822809
Glycine turnover and decarboxylation rate quantified in healthy men and women using primed, constant infusions of [1,2-(13)C2]glycine and [(2)H3]leucine.Q53515095
Vitamin B6 deficiency affects antioxidant defences in rat liver and heartQ57013686
Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory settingQ64132337
High-performance liquid chromatographic assay of erythrocyte enzyme activity levels involved in vitamin B6 metabolismQ68062714
Cysteine concentration regulates cysteine metabolism to glutathione, sulfate and taurine in rat hepatocytesQ68066065
Direct measurement of apolipoprotein B synthesis in human very low density lipoprotein using stable isotopes and mass spectrometryQ69572541
Plasma methionine and cysteine kinetics in response to an intravenous glutathione infusion in adult humansQ71464217
Comparison of serine and hippurate as precursor equivalents during infusion of [15N]glycine for measurement of fractional synthetic rates of apolipoprotein B of very-low-density lipoproteinQ71521545
Effects of exhaustive exercise and vitamin B6 deficiency on free radical oxidative process in male trained ratsQ71716409
Protein-deficient pigs cannot maintain reduced glutathione homeostasis when subjected to the stress of inflammationQ72317141
In vivo rates of erythrocyte glutathione synthesis in children with severe protein-energy malnutritionQ73532633
Glutathione turnover is increased during the acute phase of sepsis in ratsQ73763539
Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activityQ77300083
Erythrocyte glutathione deficiency in symptom-free HIV infection is associated with decreased synthesis rateQ77788848
Low pyridoxal 5'-phosphate is associated with increased risk of coronary artery diseaseQ79256266
Vitamin B-6 deficiency suppresses the hepatic transsulfuration pathway but increases glutathione concentration in rats fed AIN-76A or AIN-93G dietsQ79954676
Plasma pyridoxal 5'-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004Q81247681
Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and menQ81498008
Stability of pyridoxal-5-phosphate semicarbazone: applications in plasma vitamin B6 analysis and population surveys of vitamin B6 nutritional statusQ93633948
Inborn errors in the metabolism of glutathioneQ21203014
Regulation of hepatic glutathione synthesis: current concepts and controversies.Q33672601
Vitamin B-6: a status reportQ34262523
Glutathione metabolism and its implications for healthQ34301684
Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteineQ34326009
Synthesis of erythrocyte glutathione in healthy adults consuming the safe amount of dietary proteinQ34328608
Methionine-adequate cysteine-free diet does not limit erythrocyte glutathione synthesis in young healthy adult men.Q34599008
Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC GroupQ34745701
Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free dietQ36961927
Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and womenQ37105818
In vivo rates of erythrocyte glutathione synthesis in adults with sickle cell disease.Q39390814
Redox regulation of homocysteine-dependent glutathione synthesisQ40664755
The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changesQ40847581
Estimating glutathione synthesis with deuterated water: a model for peptide biosynthesisQ40949753
Transport accounts for glutathione turnover in human erythrocytesQ41608815
Role of pyridoxine in glutathione metabolismQ41837821
A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism.Q41912932
Measurement of intracellular sulfur amino acid metabolism in humansQ43606115
Cysteine metabolism and whole blood glutathione synthesis in septic pediatric patientsQ43617662
Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levelsQ43636903
Response of vitamin B-6 content of muscle to changes in vitamin B-6 intake in men.Q43665766
Deficiencies of folate and vitamin B(6) exert distinct effects on homocysteine, serine, and methionine kineticsQ43794362
Plasma L-5-oxoproline kinetics and whole blood glutathione synthesis rates in severely burned adult humansQ43852573
Homocysteine, vitamin B6, and vascular disease in AD patientsQ44009306
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectglutathioneQ116907
vitaminQ34956
vitamin BQ183206
P304page(s)336-343
P577publication date2009-06-10
P1433published inAmerican Journal of Clinical NutritionQ7713500
P1476titleVitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women
P478volume90

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cites work (P2860)
Q36802077Can paracetamol (acetaminophen) be administered to patients with liver impairment?
Q34684231Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contracept
Q37229200Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women
Q34775573Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects
Q34802087Moderate vitamin B-6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transsulfuration but increases the fractional synthesis rate of cystathionine in healthy young men and women.
Q38696053Risk of Deficiency in Multiple Concurrent Micronutrients in Children and Adults in the United States.
Q35561821Role of vitamin B6 status on antioxidant defenses, glutathione, and related enzyme activities in mice with homocysteine-induced oxidative stress
Q36728514Short-Term Vitamin B-6 Restriction Does Not Affect Plasma Concentrations of Hydrogen Sulfide Biomarkers Lanthionine and Homolanthionine in Healthy Men and Women
Q33839922Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells
Q64112690Vitamin B improves blood parameters in rats fed a protein-deficient diet and subjected to moderate, long-term exercise
Q36984149Vitamin B6 nutritional status and cellular availability of pyridoxal 5'-phosphate govern the function of the transsulfuration pathway's canonical reactions and hydrogen sulfide production via side reactions

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