CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice

scientific article published on September 2008

CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.181.6.3906
P932PMC publication ID2709752
P698PubMed publication ID18768845
P5875ResearchGate publication ID23235606

P50authorKeri Csencsits-SmithQ59917199
P2093author name stringGuanyi Lu
D Keith Bishop
Svetlana Grabauskiene
Bryna E Burrell
P2860cites workNFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expressionQ24556668
Control of Effector CD8 + T Cell Function by the Transcription Factor EomesoderminQ28589387
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesQ29547871
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cellsQ29614226
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cellsQ29616148
Phenotypic and functional features of human Th17 cellsQ29619323
IL-17 family cytokines and the expanding diversity of effector T cell lineagesQ29619361
Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection.Q33740453
The role of CD154 in organ transplant rejection and acceptanceQ33772261
The role of TNF receptor and TNF superfamily molecules in organ transplantationQ34719084
Non-classical pathways of cell-mediated allograft rejection: new challenges for tolerance induction?Q35072090
Contrasting alloreactive CD4+ and CD8+ T cells: there's more to it than MHC restrictionQ35072094
Heterologous immunity provides a potent barrier to transplantation toleranceQ35095576
CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responsesQ35231921
Effector mechanisms in transplant rejectionQ35583498
Heterologous immunity: an overlooked barrier to toleranceQ35583521
CD40/CD154 interactions at the interface of tolerance and immunityQ35698455
Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune diseaseQ36228235
T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17Q36228767
Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulationQ36229698
The T-box transcription factor T-bet in immunity and autoimmunityQ36476813
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune diseaseQ36747499
Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironmentQ40130406
Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6.Q40132546
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cellsQ40757721
Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival?Q41389910
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype.Q42742129
Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.Q46001789
Origins of the T(H)1-T(H)2 model: a personal perspectiveQ46303124
Evidence for a nonclassical pathway of graft rejection involving interleukin 5 and eosinophils.Q46541813
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.Q51065721
High-resolution characterization of cytokine-producing alloreactivity in naive and allograft-primed mice.Q52039522
T-cell costimulatory pathways in allograft rejection and toleranceQ56902638
The role of the IL-2 pathway in costimulation blockade-resistant rejection of allograftsQ56904634
IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathwaysQ56907841
What does it mean to be just 17?Q59072217
Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent MechanismQ61357092
Mobilization of T lymphocytes following cardiac transplantation. Evidence that CD4-positive cells are required for cytotoxic T lymphocyte activation, inflammatory endothelial development, graft infiltration, and acute allograft rejectionQ68054864
IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. Evidence against a dominant protective role for T helper 2 cytokines in alloimmunityQ71396687
In vivo depletion of CD8+ T cells results in Th2 cytokine production and alternate mechanisms of allograft rejectionQ72196808
Immunobiology of allograft rejection in the absence of IFN-gamma: CD8+ effector cells develop independently of CD4+ cells and CD40-CD40 ligand interactionsQ73509932
The immunobiology of inductive anti-CD40L therapy in transplantation: allograft acceptance is not dependent upon the deletion of graft-reactive T cellsQ74464420
Alloantigen-reactive Th1 development in IL-12-deficient miceQ74506164
Development of spontaneous airway changes consistent with human asthma in mice lacking T-betQ77476285
Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditisQ79236402
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitisQ79755041
Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infectionQ79929535
Understanding the IL-23-IL-17 immune pathwayQ81485100
Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitisQ82136598
Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejectionQ93747372
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)3906-3914
P577publication date2008-09-01
P1433published inJournal of ImmunologyQ3521441
P1476titleCD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice
P478volume181

Reverse relations

cites work (P2860)
Q39835072A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity
Q90701402A novel model for dissecting roles of IL-17 in lung transplantation
Q48025939A pathogenic role of IL- 17 at the early stage of corneal allograft rejection
Q54628324Absence of IL-23p19 in donor allogeneic cells reduces mortality from acute GVHD.
Q36280335Absence of MyD88 signaling induces donor-specific kidney allograft tolerance
Q44561822Absence of donor CD40 protects renal allograft epithelium and preserves renal function.
Q54418980Administration of anti-interleukin-6 monoclonal antibody prolongs cardiac allograft survival.
Q38081174CD4(+) T-cell subsets in transplantation
Q35816448CD8(+)IL-17(+) T Cells Mediate Neutrophilic Airway Obliteration in T-bet-Deficient Mouse Lung Allograft Recipients
Q33913346CXC chemokine ligand (CXCL) 9 and CXCL10 are antagonistic costimulation molecules during the priming of alloreactive T cell effectors
Q34484754Coevolution of TH1, TH2, and TH17 responses during repeated pulmonary exposure to Aspergillus fumigatus conidia.
Q33811918Connective tissue growth factor promotes fibrosis downstream of TGFbeta and IL-6 in chronic cardiac allograft rejection.
Q37373747Critical role for IL-6 in hypertrophy and fibrosis in chronic cardiac allograft rejection
Q50002899Differential modulation of IL-12 family cytokines in autoimmune islet graft failure in mice
Q37977126Direct and indirect regulatory mechanisms in TH17 cell differentiation and functions
Q85203273Eicosapentaenoic Acid Disrupts the Balance Between Tregs and IL-17+ T Cells Through PPARγ Nuclear Receptor Activation and Protects Cardiac Allografts
Q85370236Expression levels of Notch1 and Delta-like 4 in peripheral lymphocytes and their relationship with T helper 17 (Th17) cells in renal transplant recipients
Q38216200Heterogeneity in the differentiation and function of CD8⁺ T cells
Q35022593IL-17A and IL-2-expanded regulatory T cells cooperate to inhibit Th1-mediated rejection of MHC II disparate skin grafts
Q35032693IL-17A-dependent CD4+CD25+ regulatory T cells promote immune privilege of corneal allografts
Q38328539IL-17A-producing CD8(+)T cells as therapeutic targets in autoimmunity.
Q35566506IL-6 promotes cardiac graft rejection mediated by CD4+ cells
Q37864694Immunologic unresponsiveness to alloantigen in vivo: a role for regulatory T cells
Q38008077Immunology mini-review: the basics of T(H)17 and interleukin-6 in transplantation
Q39440909Infectious pathogens may trigger specific allo-HLA reactivity via multiple mechanisms.
Q33823699Inflammation and transplantation tolerance
Q42025217Innate immunity and resistance to tolerogenesis in allotransplantation
Q34086917Interleukin-17 promotes early allograft inflammation
Q37273910Interleukins 17 and 23 influence the host response to Histoplasma capsulatum
Q57462291Loss of T-bet confers survival advantage to influenza-bacterial superinfection
Q37836540Loss of tolerance to self after transplant
Q43106558Mycophenolic acid suppresses granulopoiesis by inhibition of interleukin-17 production
Q36694466NK cells inhibit T-bet-deficient, autoreactive Th17 cells
Q88200625Platelet factor 4 protects kidney allograft in a rat kidney transplantation model
Q35813877Protective role of T-bet and Th1 cytokines in pulmonary graft-versus-host disease and peribronchiolar fibrosis.
Q56547729RETRACTED: Blockade of NKG2D synergized with CTLA4-Ig in promoting long-term graft survival in murine models of cardiac transplantation
Q37721479Recent progress and new perspectives in studying T cell responses to allografts
Q42232279Regulatory role of CD4(+)CD25 (+)Foxp3 (+) regulatory T cells on IL-17-secreting T cells in chronic hepatitis B patients
Q37622866Role of Th17 cells and IL-17 in lung transplant rejection
Q37411201Sequential evolution of IL-17 responses in the early period of allograft rejection.
Q28486264Significance and suppression of redundant IL17 responses in acute allograft rejection by bioinformatics based drug repositioning of fenofibrate
Q37012868Structure and function of major histocompatibility complex class I antigens
Q46019531T helper 1, 2 and 17 cell subsets in renal transplant patients with delayed graft function.
Q38185124T helper subsets & regulatory T cells: rethinking the paradigm in the clinical context of solid organ transplantation
Q37891668T-bet in disease.
Q42110315T-bet protects against exacerbation of schistosome egg-induced immunopathology by regulating Th17-mediated inflammation
Q28589692T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt
Q33873078T-cell co-stimulatory blockade in kidney transplantation: back to the bench
Q38148197T-cell co-stimulatory blockade in transplantation: two steps forward one step back!
Q36749425TIM-3: a novel regulatory molecule of alloimmune activation.
Q33711191TLR signals promote IL-6/IL-17-dependent transplant rejection.
Q37249890Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.
Q38150101Targeting co-stimulatory pathways: transplantation and autoimmunity
Q54976588Targeting the class IA PI3K isoforms p110α/δ attenuates heart allograft rejection in mice by suppressing the CD4+ T lymphocyte response.
Q34856750Tc17 CD8 T cells: functional plasticity and subset diversity.
Q38254602Tc17 Cells in Immunity and Systemic Autoimmunity
Q35327827Th17 cells and transplant acceptance
Q53385340Th17 cells induce a distinct graft rejection response that does not require IL-17A.
Q37771228The impact of Th17 cells on transplant rejection and the induction of tolerance
Q37587334Tim-1-Fc suppresses chronic cardiac allograft rejection and vasculopathy by reducing IL-17 production
Q35164666Transient blockade of delta-like Notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation.
Q51007543γδ T cell receptor deficiency attenuated cardiac allograft vasculopathy and promoted regulatory T cell expansion.

Search more.