Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/β-catenin signaling

scientific article published on 19 August 2013

Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/β-catenin signaling is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.00418-13
P932PMC publication ID3811687
P698PubMed publication ID23959799

P2093author name stringXin Wang
Lin Li
Chen Li
Rong Zeng
Li Mao
Xiaoli He
Yuelei Chen
Zhenfei Li
Cong Fei
Zhangcheng Chen
P2860cites workA SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formationQ22003817
Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligaseQ24290743
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signallingQ24299327
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of DvlQ24302528
Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membraneQ24303055
Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylationQ24309342
The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-cateninQ24310085
Regulation of planar cell polarity by Smurf ubiquitin ligasesQ24317525
Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradationQ24321456
Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.Q24534260
Wnt/beta-catenin signaling in development and diseaseQ27860784
The Wnt signaling pathway in development and diseaseQ27861019
Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathwayQ28118992
Regulation of cell polarity and protrusion formation by targeting RhoA for degradationQ28189565
The ubiquitin codeQ28265104
Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cellsQ28297767
Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradationQ28513591
Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signalingQ28595033
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantificationQ29547200
Nonproteolytic functions of ubiquitin in cell signalingQ29617294
Protein regulation by monoubiquitinQ29620221
The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpointQ30484127
The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2)Q30989535
Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylationQ33366930
Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarityQ34176698
Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interactionQ34871118
Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts.Q35156225
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.Q35619339
Smurf1 protein negatively regulates interferon-γ signaling through promoting STAT1 protein ubiquitination and degradationQ36006811
The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled proteinQ36277250
HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.Q36596124
Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilutionQ36731097
BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signallingQ37084834
The HECT family of E3 ubiquitin ligases: multiple players in cancer developmentQ37206488
Smad6 inhibits the transcriptional activity of Tbx6 by mediating its degradationQ37358135
The various roles of ubiquitin in Wnt pathway regulation.Q37798661
Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages.Q38028343
Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.Q40036004
Phosphorylation of E3 ligase Smurf1 switches its substrate preference in support of axon developmentQ44702276
Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometryQ79491768
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)4095-4105
P577publication date2013-08-19
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleSmurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/β-catenin signaling
P478volume33

Reverse relations

cites work (P2860)
Q24304398ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance
Q90749875Axin Family of Scaffolding Proteins in Development: Lessons from C. elegans
Q64068213Detailed Dissection of UBE3A-Mediated DDI1 Ubiquitination
Q38606750E3 ubiquitin ligases in regulating stress fiber, lamellipodium, and focal adhesion dynamics
Q38870518EGF Inhibits Wnt/β-Catenin-Induced Osteoblast Differentiation by Promoting β-Catenin Degradation
Q55021581Generation of Smurf2 Conditional Knockout Mice.
Q89967592How to Inactivate Human Ubiquitin E3 Ligases by Mutation
Q36676430Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins.
Q36594044Linkage-specific conformational ensembles of non-canonical polyubiquitin chains
Q83227819N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration
Q37666459New insights into the regulation of Axin function in canonical Wnt signaling pathway
Q91707618Nonproteolytic K29-Linked Ubiquitination of the PB2 Replication Protein of Influenza A Viruses by Proviral Cullin 4-Based E3 Ligases
Q55324989Overexpression of HACE1 in gastric cancer inhibits tumor aggressiveness by impeding cell proliferation and migration.
Q38239592Rapid development of proteomics in China: from the perspective of the Human Liver Proteome Project and technology development
Q52654047Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking.
Q38193259Regulation of Wnt/β-catenin signaling by posttranslational modifications
Q89700542Ring finger protein 5 activates sterol regulatory element-binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP
Q49469323SMURF1 facilitates estrogen receptor ɑ signaling in breast cancer cells.
Q102141757SMURF1, a promoter of tumor cell progression?
Q51193182SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling.
Q39005862Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways
Q33619482Smurf1-mediated axin ubiquitination requires Smurf1 C2 domain and is cell cycle-dependent
Q54979954TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis.
Q38948247TRIB2 inhibits Wnt/β-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, β-TrCP, COP1 and Smurf1, in liver cancer cells
Q47745372The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy
Q90093670The role of ubiquitination in tumorigenesis and targeted drug discovery
Q92147741USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification
Q26767117Ubiquitin chain diversity at a glance
Q58606339Ubiquitination in Scleroderma Fibrosis and Its Treatment
Q37637735Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains

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