Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members

scientific article published on 05 May 2009

Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/PHYSIOLGENOMICS.90309.2008
P932PMC publication ID2712220
P698PubMed publication ID19417012

P50authorSanjay K NigamQ111165276
P2093author name stringWei Wu
Michael E Baker
Kevin T Bush
Satish A Eraly
P2860cites workMolecular identification of a renal urate anion exchanger that regulates blood urate levelsQ24297979
Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrateQ24301143
Global variation in copy number in the human genomeQ24658083
Mutations of OCTN2, an organic cation/carnitine transporter, lead to deficient cellular carnitine uptake in primary carnitine deficiencyQ28138497
Organic anion and cation transporters occur in pairs of similar and similarly expressed genesQ28198250
Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and RoctQ28508498
Drug excretion mediated by a new prototype of polyspecific transporterQ28568689
Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidneyQ28576093
Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidneyQ28592258
Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transportersQ28624134
Hidden Markov model analysis of motifs in steroid dehydrogenases and their homologsQ30426715
Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestineQ30829378
Identification of six putative human transporters with structural similarity to the drug transporter SLC22 familyQ33294945
Organic anion and cation transporter expression and function during embryonic kidney development and in organ culture modelsQ33674894
Isolation of a family of organic anion transporters from human liver and kidneyQ33944666
Predicting the three-dimensional structure of the human facilitative glucose transporter glut1 by a novel evolutionary homology strategy: insights on the molecular mechanism of substrate migration, and binding sites for glucose and inhibitory molecuQ34187609
Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transportersQ34309854
Multiple organic anion transporters contribute to net renal excretion of uric acidQ34470733
Transport of organic anions across the basolateral membrane of proximal tubule cellsQ35073206
A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transportQ35740999
Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discriminationQ36704152
Mutations in the organic cation/carnitine transporter OCTN2 in primary carnitine deficiencyQ37183587
A conserved glutamate residue in transmembrane helix 10 influences substrate specificity of rabbit OCT2 (SLC22A2).Q40398708
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family membersQ41905911
Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levelsQ42461979
An artificial intelligence approach to motif discovery in protein sequences: application to steriod dehydrogenases.Q42667238
Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice.Q43993855
Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradientQ44253313
Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permeaseQ45232114
Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice.Q46312451
P433issue2
P304page(s)116-124
P577publication date2009-05-05
P1433published inPhysiological GenomicsQ2506446
P1476titleAnalysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members
P478volume38

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cites work (P2860)
Q35128143Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury
Q28550639Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs
Q35080483Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney
Q37001887Growth hormone treatment of premature ovarian failure in a mouse model via stimulation of the Notch-1 signaling pathway
Q33500929Interaction of organic cations with organic anion transporters
Q95795711Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach
Q37193094Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways
Q36103220Phylogenetic, syntenic, and tissue expression analysis of slc22 genes in zebrafish (Danio rerio).
Q34865706Remote communication through solute carriers and ATP binding cassette drug transporter pathways: an update on the remote sensing and signaling hypothesis
Q36316477Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors
Q90162435Systems Biology Analysis Reveals Eight SLC22 Transporter Subgroups, Including OATs, OCTs, and OCTNs
Q47198594The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease.
Q38648038The drug transporter OAT3 (SLC22A8) regulates endogenous metabolite flow through the gut-liver-kidney axis
Q28085671The organic anion transporter (OAT) family: a systems biology perspective
Q37314370Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis
Q90280032Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies
Q35446350Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1).
Q36571217What do drug transporters really do?

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