Inhibition of RORα/γ suppresses atherosclerosis via inhibition of both cholesterol absorption and inflammation

scientific article published on 25 July 2016

Inhibition of RORα/γ suppresses atherosclerosis via inhibition of both cholesterol absorption and inflammation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MOLMET.2016.07.001
P932PMC publication ID5034492
P698PubMed publication ID27689012

P50authorThomas BurrisQ67982842
P2093author name stringCyrielle Billon
Sadichha Sitaula
P2860cites workInterleukin-4 deficiency promotes gallstone formationQ24295010
Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterolQ24306058
Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesisQ24642725
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gammaQ28506783
Atherosclerosis. the road aheadQ29618972
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammationQ34474230
Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscleQ34768447
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolismQ34976906
Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-associated inflammation and hepatic steatosisQ35095209
Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligandQ35143424
Attenuated atherosclerotic lesions in apoE-Fcγ-chain-deficient hyperlipidemic mouse model is associated with inhibition of Th17 cells and promotion of regulatory T cellsQ35566640
Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in miceQ36202916
Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosisQ37377439
The T(reg)/Th17 cell balance: a new paradigm for autoimmunityQ37393703
T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemiaQ43624009
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in self-tolerance and autoimmune diseaseQ56902429
Natural regulatory T cells control the development of atherosclerosis in miceQ58149268
Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalphaQ77677370
Role of naturally occurring CD4+ CD25+ regulatory T cells in experimental atherosclerosisQ79711302
Cellular immunity, low-density lipoprotein and atherosclerosis: break of tolerance in the artery wallQ85054596
CD4+ T cells in atherosclerosis: regulation by plateletsQ86213488
P4510describes a project that usesImageJQ1659584
P433issue10
P921main subjectinflammationQ101991
atherosclerosisQ12252367
P304page(s)997-1005
P577publication date2016-07-25
P1433published inMolecular MetabolismQ27724805
P1476titleInhibition of RORα/γ suppresses atherosclerosis via inhibition of both cholesterol absorption and inflammation
P478volume5

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cites work (P2860)
Q92540743A Critical Role of PCSK9 in Mediating IL-17-Producing T Cell Responses in Hyperlipidemia
Q50055223Adropin: An endocrine link between the biological clock and cholesterol homeostasis
Q51132724Central role of T helper 17 cells in chronic hypoxia-induced pulmonary hypertension.
Q88921523Emerging role of circadian clock disruption in alcohol-induced liver disease
Q38661300Metabolic Characterization of a Novel RORα Knockout Mouse Model without Ataxia
Q89296979Pharmacological activation of REV-ERBα represses LPS-induced microglial activation through the NF-κB pathway
Q93222327RORγ regulates the NLRP3 inflammasome
Q88141299Retinoic acid-related Orphan Receptor γ (RORγ): connecting sterol metabolism to regulation of the immune system and autoimmune disease
Q61812343Small Molecule Modulators of the Circadian Molecular Clock With Implications for Neuropsychiatric Diseases