| scholarly article | Q13442814 |
| P50 | author | Anton M. Jetten | Q37382404 |
| P2093 | author name string | Hong Soon Kang | |
| Andrzej Slominski | |||
| Yukimasa Takeda | |||
| P2860 | cites work | Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma | Q24301662 |
| ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle | Q24308275 | ||
| Oxysterols direct immune cell migration via EBI2 | Q24317301 | ||
| Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors | Q24322658 | ||
| Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands | Q24336344 | ||
| Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta | Q24553340 | ||
| Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages | Q24642180 | ||
| Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis | Q24642725 | ||
| Post-translational regulation of RORγt-A therapeutic target for the modulation of interleukin-17-mediated responses in autoimmune diseases | Q26740155 | ||
| Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity | Q26863295 | ||
| Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors | Q41108727 | ||
| Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols | Q41200217 | ||
| TH17 cell differentiation is regulated by the circadian clock. | Q41809497 | ||
| Immunology: A helping hand against autoimmunity | Q42534508 | ||
| RORγt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease. | Q42700037 | ||
| High incidence of T-cell lymphomas in mice deficient in the retinoid-related orphan receptor RORgamma. | Q43878486 | ||
| A two-amino-acid substitution in the transcription factor RORγt disrupts its function in TH17 differentiation but not in thymocyte development. | Q46075995 | ||
| SUMOylation of RORalpha potentiates transcriptional activation function. | Q46223432 | ||
| Synthesis and Biological Evaluation of New Triazolo- and Imidazolopyridine RORγt Inverse Agonists | Q46452260 | ||
| The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity. | Q46623322 | ||
| Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo. | Q47097758 | ||
| Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity | Q47129226 | ||
| Group 3 Innate Lymphoid Cells: Communications Hubs of the Intestinal Immune System | Q47138366 | ||
| The intestinal microbiota regulates body composition through NFIL3 and the circadian clock. | Q47163566 | ||
| SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology | Q47692117 | ||
| Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors | Q47879931 | ||
| Structural States of RORγt: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds. | Q48014086 | ||
| Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-γt ubiquitination. | Q48193515 | ||
| Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) i | Q50268732 | ||
| Identification of tertiary sulfonamides as RORc inverse agonists. | Q50458464 | ||
| RORγt inhibitors as potential back-ups for the phase II candidate VTP-43742 from Vitae Pharmaceuticals: patent evaluation of WO2016061160 and US20160122345. | Q51324517 | ||
| Retinoid-related orphan receptor γ (RORγ) adult induced knockout mice develop lymphoblastic lymphoma. | Q51435866 | ||
| Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ. | Q51442356 | ||
| Retinoid-related orphan receptor gamma t (RORγt) inhibitors from Vitae Pharmaceuticals (WO2015116904) and structure proposal for their Phase I candidate VTP-43742. | Q53170530 | ||
| Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors. | Q53301557 | ||
| Protein kinase A activates and phosphorylates RORα4 in vitro and takes part in RORα activation by CaMK-IV. | Q54594902 | ||
| Exacerbation of type II collagen-induced arthritis in apolipoprotein E-deficient mice in association with the expansion of Th1 and Th17 cells | Q83173546 | ||
| Defining the functional states of Th17 cells | Q26998296 | ||
| Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis. | Q27335241 | ||
| X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha | Q27640112 | ||
| Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A | Q27642943 | ||
| Structural Basis of Digoxin That Antagonizes ROR t Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production | Q27670714 | ||
| A reversed sulfonamide series of selective RORc inverse agonists | Q27696283 | ||
| Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH 17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor RORγ | Q27702597 | ||
| The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells | Q27860620 | ||
| Group 3 innate lymphoid cells (ILC3s): Origin, differentiation, and plasticity in humans and mice | Q28081074 | ||
| Requirement for RORgamma in thymocyte survival and lymphoid organ development | Q28139666 | ||
| The role of the nuclear hormone receptor RORγt in the development of lymph nodes and Peyer's patches | Q28206376 | ||
| Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists | Q28254889 | ||
| Cloning of a cDNA encoding the murine orphan receptor RZR/ROR gamma and characterization of its response element | Q28299853 | ||
| Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity | Q28302355 | ||
| Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc) | Q28307363 | ||
| T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma | Q28506783 | ||
| Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin | Q28550171 | ||
| RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo | Q28586352 | ||
| Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism | Q28594055 | ||
| Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells | Q28829881 | ||
| Protein sensors for membrane sterols | Q29617313 | ||
| Identification of an allosteric binding site for RORγt inhibition | Q30394306 | ||
| The effect of Am-80, one of retinoids derivatives on experimental allergic encephalomyelitis in rats | Q31483941 | ||
| Innate IL-17-producing cells: the sentinels of the immune system | Q33608575 | ||
| Retinoic acid-related orphan receptor γ (RORγ): a novel participant in the diurnal regulation of hepatic gluconeogenesis and insulin sensitivity | Q33617767 | ||
| RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D. | Q33775152 | ||
| Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms | Q33791610 | ||
| An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition | Q33798102 | ||
| A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol) | Q33915348 | ||
| Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation. | Q34082917 | ||
| Retinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes | Q34249578 | ||
| Action of RORs and their ligands in (patho)physiology. | Q34287702 | ||
| Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases | Q34315555 | ||
| REV-ERB and ROR nuclear receptors as drug targets. | Q34407313 | ||
| Recent progress on nuclear receptor RORγ modulators | Q34537890 | ||
| RORγ antagonists and inverse agonists: a patent review | Q34540327 | ||
| Oxysterols: From cholesterol metabolites to key mediators. | Q34541558 | ||
| Normocaloric low cholesterol diet modulates Th17/Treg balance in patients with chronic hepatitis C virus infection | Q34756669 | ||
| Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist | Q34789625 | ||
| Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism | Q34976906 | ||
| Retinoic acid-related orphan receptor γ directly regulates neuronal PAS domain protein 2 transcription in vivo | Q35040936 | ||
| Identification of natural RORγ ligands that regulate the development of lymphoid cells | Q35050670 | ||
| Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein | Q35067655 | ||
| ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes | Q35088799 | ||
| Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo | Q35091158 | ||
| Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-associated inflammation and hepatic steatosis | Q35095209 | ||
| The REV-ERBs and RORs: molecular links between circadian rhythms and lipid homeostasis | Q35099319 | ||
| Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand | Q35143424 | ||
| Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity | Q35210669 | ||
| SIRT1 deacetylates RORγt and enhances Th17 cell generation | Q35568434 | ||
| MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORγt⁺ T cells | Q35687488 | ||
| MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells. | Q35745717 | ||
| Antiobesity Effect of a Small Molecule Repressor of RORγ. | Q35745907 | ||
| Pharmacologic repression of retinoic acid receptor-related orphan nuclear receptor γ is therapeutic in the collagen-induced arthritis experimental model | Q35760186 | ||
| RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages | Q35905052 | ||
| The microbiome and innate immunity | Q36069070 | ||
| Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland. | Q36134223 | ||
| Oral administration of a novel RORγt antagonist attenuates psoriasis-like skin lesion of two independent mouse models through neutralization of IL-17. | Q36160256 | ||
| In vivo evidence for a novel pathway of vitamin D₃ metabolism initiated by P450scc and modified by CYP27B1. | Q36183704 | ||
| Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity | Q36232234 | ||
| CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity | Q36352360 | ||
| Transcriptome profiling unveils the role of cholesterol in IL-17A signaling in psoriasis | Q36500064 | ||
| Determinants of target gene specificity for ROR alpha 1: monomeric DNA binding by an orphan nuclear receptor | Q36550845 | ||
| Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity | Q36562670 | ||
| Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism | Q36571294 | ||
| Novel activities of CYP11A1 and their potential physiological significance. | Q36591625 | ||
| Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity | Q36839721 | ||
| Transcriptional regulation of Th17 cell differentiation | Q37021803 | ||
| Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ. | Q37238055 | ||
| Inhibition of RORα/γ suppresses atherosclerosis via inhibition of both cholesterol absorption and inflammation | Q37278564 | ||
| Retinoic acid-related orphan receptor α regulates diurnal rhythm and fasting induction of sterol 12α-hydroxylase in bile acid synthesis | Q37415659 | ||
| Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis | Q37460263 | ||
| Synthetic RORγt Agonists Enhance Protective Immunity | Q37526761 | ||
| Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling | Q37591214 | ||
| Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations. | Q37677422 | ||
| Statins: from cholesterol-lowering drugs to novel immunomodulators for the treatment of Th17-mediated autoimmune diseases | Q38198394 | ||
| Uncoupling nuclear receptor LXR and cholesterol metabolism in cancer | Q38415891 | ||
| N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists | Q38434701 | ||
| CYP19A1, MIF and ABCA1 genes are targets of the RORα in monocyte and endothelial cells. | Q38727292 | ||
| Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells | Q38750834 | ||
| Innate lymphoid cells in secondary lymphoid organs | Q38810910 | ||
| Tolerance to the Intestinal Microbiota Mediated by ROR(γt)(+) Cells | Q38851818 | ||
| Oxysterols in Metabolic Syndrome: From Bystander Molecules to Bioactive Lipids. | Q38861390 | ||
| Immunity around the clock | Q39019210 | ||
| Functional and phenotypic heterogeneity of group 3 innate lymphoid cells | Q39034173 | ||
| Small molecule mediated inhibition of RORγ-dependent gene expression and autoimmune disease pathology in vivo | Q40180519 | ||
| Oxysterols are allosteric activators of the oncoprotein Smoothened | Q40530687 | ||
| P921 | main subject | autoimmune disease | Q8084905 |
| P304 | page(s) | 66-80 | |
| P577 | publication date | 2018-02-01 | |
| P1476 | title | Retinoic acid-related Orphan Receptor γ (RORγ): connecting sterol metabolism to regulation of the immune system and autoimmune disease | |
| P478 | volume | 8 |
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