Translocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis

scientific article published on May 2009

Translocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M901902200
P932PMC publication ID2719417
P698PubMed publication ID19411255
P5875ResearchGate publication ID24397823

P2093author name stringHeidi M McBride
Liqun Xu
Rodolfo Zunino
Emélie Braschi
P2860cites workTOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteinsQ24292751
A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamicsQ24298316
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53Q24299024
Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunctionQ36995104
Ulp2 and the DNA damage response: desumoylation enables safe passage through mitosisQ37057564
The E3 ligase Topors induces the accumulation of polysumoylated forms of DNA topoisomerase I in vitro and in vivoQ40058676
The synthesis of acidic chromosomal proteins during the cell cycle of HeLa S-3 cells. I. The accelerated accumulation of acidic residual nuclear protein before the initiation of DNA replicationQ41150190
Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in DrosophilaQ44349060
Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpointQ45069287
Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarizationQ46477108
Mitochondrial movement and inheritance in budding yeastQ46567378
Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fissionQ47197847
Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology.Q53548157
Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.Q53571110
Dimeric Dnm1-G385D interacts with Mdv1 on mitochondria and can be stimulated to assemble into fission complexes containing Mdv1 and Fis1.Q53628380
The SUMO protease SENP5 is required to maintain mitochondrial morphology and functionQ56907347
Intermolecular and interdomain interactions of a dynamin-related GTP-binding protein, Dnm1p/Vps1p-like proteinQ77896851
MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphologyQ24300832
PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencingQ24303619
The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial divisionQ24316439
Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondriaQ24320227
SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosisQ24647369
Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific proteaseQ24669884
SUSP1 antagonizes formation of highly SUMO2/3-conjugated speciesQ24682911
Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3.Q27863917
The SUMO-specific protease SENP5 is required for cell divisionQ27863924
Dnm1 forms spirals that are structurally tailored to fit mitochondriaQ27930356
The role of karyopherins in the regulated sumoylation of septinsQ27936933
A new protease required for cell-cycle progression in yeastQ27938681
The nucleoporin RanBP2 has SUMO1 E3 ligase activityQ28115025
The polycomb protein Pc2 is a SUMO E3Q28115324
The Ki-67 protein: from the known and the unknownQ28143714
The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosisQ28247891
In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategyQ28253409
Concepts in sumoylation: a decade onQ28257220
PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcriptionQ28258345
Phosphorylation of SUMO-1 occurs in vivo and is conserved through evolutionQ28291034
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transitionQ28301955
Modification in reverse: the SUMO proteasesQ28302162
Protein modification by SUMOQ29547919
Mitochondria: more than just a powerhouseQ29617386
Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell deathQ29620448
Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell deathQ30480587
The machinery of mitochondrial inheritance and behaviorQ33538526
The GTPase effector domain sequence of the Dnm1p GTPase regulates self-assembly and controls a rate-limiting step in mitochondrial fissionQ33946730
Cell-cycle-dependent localisation of Ulp1, a Schizosaccharomyces pombe Pmt3 (SUMO)-specific protease.Q34117514
The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificityQ34185745
Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1.Q34340187
Noncovalent binding of small ubiquitin-related modifier (SUMO) protease to SUMO is necessary for enzymatic activities and cell growthQ34618303
Mitotic arrest and cell fate: why and how mitotic inhibition of transcription drives mutually exclusive eventsQ36716332
P433issue26
P407language of work or nameEnglishQ1860
P921main subjectmitochondrionQ39572
P304page(s)17783-17795
P577publication date2009-05-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleTranslocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis
P478volume284

Reverse relations

cites work (P2860)
Q58702057A Disturbance in the Force: Cellular Stress Sensing by the Mitochondrial Network
Q34277011ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major
Q33845021Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases
Q35683658Activation of the pleiotropic drug resistance pathway can promote mitochondrial DNA retention by fusion-defective mitochondria in Saccharomyces cerevisiae
Q35879646Allosteric modulation of Drp1 mechanoenzyme assembly and mitochondrial fission by the variable domain
Q24630079An intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationship
Q26853356Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease
Q39386692Concepts and Methodologies to Study Protein SUMOylation: An Overview.
Q30587324Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging
Q39136019Coordination of Cellular Localization-Dependent Effects of Sumoylation in Regulating Cardiovascular and Neurological Diseases
Q36593242Different molecular mechanisms involved in spontaneous and oxidative stress-induced mitochondrial fragmentation in tripeptidyl peptidase-1 (TPP-1)-deficient fibroblasts
Q27313862Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration
Q94464358Distinct Contributions of the Peroxisome-Mitochondria Fission Machinery During Sexual Development of the Fungus Podospora anserina
Q90206029Divide et Impera: Drp1-mediated Mitochondrial Fission in Glioma Malignancy
Q90589756Drp1 modulates mitochondrial stress responses to mitotic arrest
Q37631600Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals
Q30819969Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission-fusion balance within mitochondrial networks
Q28300234Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases
Q35102259Dynamin-related protein 1 as a therapeutic target in cardiac arrest
Q38192623Dysfunctional Mitochondrial Dynamics in the Pathophysiology of Neurodegenerative Diseases
Q92811394Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson's Disease
Q92327896ELMOD2 regulates mitochondrial fusion in a mitofusin-dependent manner, downstream of ARL2
Q33790264Expression, Localization of SUMO-1, and Analyses of Potential SUMOylated Proteins in Bubalus bubalis Spermatozoa.
Q39063397Flow signaling and atherosclerosis
Q26991707Function and regulation of SUMO proteases
Q33761494Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells
Q28295816Human mitochondrial Fis1 links to cell cycle regulators at G2/M transition
Q35708874Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction
Q40240693Inhibition of SENP5 suppresses cell growth and promotes apoptosis in osteosarcoma cells
Q24337363Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission
Q37969636Less than perfect divorces: dysregulated mitochondrial fission and neurodegeneration.
Q27322213Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1
Q97884884Mechanisms and roles of mitochondrial localisation and dynamics in neuronal function
Q41949133Metabolic Stress and Disorders Related to Alterations in Mitochondrial Fission or Fusion
Q37786292Mitochondria and the culture of the Borg: understanding the integration of mitochondrial function within the reticulum, the cell, and the organism.
Q37688339Mitochondria in lung diseases
Q47752734Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages
Q35637102Mitochondrial Fragmentation Due to Inhibition of Fusion Increases Cyclin B through Mitochondrial Superoxide Radicals
Q37793525Mitochondrial dynamics
Q39084933Mitochondrial dynamics as regulators of cancer biology
Q90374857Mitochondrial dynamics: overview of molecular mechanisms
Q38128781Mitochondrial fission-fusion as an emerging key regulator of cell proliferation and differentiation
Q37686252Mitochondrial protein quality control in health and disease
Q37690524Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis
Q34295237Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction
Q37686829Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5-dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics
Q28115112Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes
Q49189773Phosphorylation and ubiquitination of dynamin-related proteins (AtDRP3A/3B) synergically regulate mitochondrial proliferation during mitosis.
Q26862395Quality matters: how does mitochondrial network dynamics and quality control impact on mtDNA integrity?
Q26829588Recent advances into the understanding of mitochondrial fission
Q30499681Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability
Q35929111Regulators of mitochondrial dynamics in cancer
Q45301628Ribosomal DNA copy number is coupled with gene expression variation and mitochondrial abundance in humans
Q38927612SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death
Q50641117SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy.
Q38115253SUMO and ischemic tolerance
Q39643661SUMO modification selectively regulates transcriptional activity of peroxisome-proliferator-activated receptor γ in C2C12 myotubes
Q99616863SUMO promotes longevity and maintains mitochondrial homeostasis during ageing in Caenorhabditis elegans
Q38132691SUMO rules: regulatory concepts and their implication in neurologic functions.
Q38757045SUMO-regulated mitochondrial function in Parkinson's disease
Q36492834SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1α.
Q38260216SUMO-specific proteases/isopeptidases: SENPs and beyond
Q24318317SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle
Q26776081SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer
Q37641735Shaping the mitochondrion: mitochondrial biogenesis, dynamics and dysfunction. Conference on Mitochondrial Assembly and Dynamics in Health and Disease
Q47761796Significance of Mitochondrial Protein Post-translational Modifications in Pathophysiology of Brain Injury
Q38118140Starting and stopping SUMOylation. What regulates the regulator?
Q39107046Sub-cellular localization specific SUMOylation in the heart
Q34532535TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression
Q37728628Targets and consequences of protein SUMOylation in neurons.
Q47750556The ARL2 GTPase regulates mitochondrial fusion from the intermembrane space
Q41669688The SUMO protease SENP6 is a direct regulator of PML nuclear bodies
Q89767729The cell biology of mitochondrial membrane dynamics
Q48056516The ever-growing complexity of the mitochondrial fission machinery
Q35532033The mitochondrial proteome: a dynamic functional program in tissues and disease states
Q39414023The regulation of tumor cell physiology by mitochondrial dynamics
Q34825960Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission
Q34347040Ubiquitin and ubiquitin-like proteins in the nucleolus: multitasking tools for a ribosome factory.
Q37167514WWOX dysfunction induces sequential aggregation of TRAPPC6AΔ, TIAF1, tau and amyloid β, and causes apoptosis
Q38182534Wrestling with stress: roles of protein SUMOylation and deSUMOylation in cell stress response

Search more.