Moderate and high amounts of tamoxifen in αMHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death.

scientific article published on 07 August 2013

Moderate and high amounts of tamoxifen in αMHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/DMM.010447
P932PMC publication ID3820268
P698PubMed publication ID23929941

P50authorBalakrishnan GanapathyQ84649467
P2093author name stringStuart Walsh
Brian D Polizzotti
Bernhard Kühn
Shima Arab
Sangita Choudhury
Kevin Bersell
Brian Wadugu
Mariya Mollova
P2860cites workCardiac-Specific Loss of N-Cadherin Leads to Alteration in Connexins With Conduction Slowing and ArrhythmogenesisQ57396516
Transgenic expression of green fluorescence protein can cause dilatedcardiomyopathyQ61995637
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Switch from caspase-dependent to caspase-independent death during heart development: essential role of endonuclease G in ischemia-induced DNA processing of differentiated cardiomyocytesQ83929474
Intrapericardial delivery of gelfoam enables the targeted delivery of Periostin peptide after myocardial infarction by inducing fibrin clot formationQ27303167
A new mathematical model for relative quantification in real-time RT-PCRQ27860781
Generalized lacZ expression with the ROSA26 Cre reporter strainQ27860837
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Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injuryQ28252995
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Growth inhibition and DNA damage induced by Cre recombinase in mammalian cellsQ33930407
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Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injuryQ34657173
Systolic dysfunction in cardiac-specific ligand-inducible MerCreMer transgenic miceQ35087050
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Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathwayQ35740259
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Mammalian genomes contain active recombinase recognition sitesQ40898133
High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly.Q41919230
Avoidance of transient cardiomyopathy in cardiomyocyte-targeted tamoxifen-induced MerCreMer gene deletion modelsQ42560803
Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alphaMHC-MerCreMer) miceQ42923082
Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre proteinQ43664631
Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2.Q46043692
Tamoxifen modulates apoptosis in multiple modes of action in CreER miceQ46185200
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Effect of caspase inhibitors on myocardial infarct size and myocyte DNA fragmentation in the ischemia-reperfused rat heartQ47243708
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P275copyright licenseCreative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P433issue6
P921main subjectheart failureQ181754
tamoxifenQ412178
DNA damageQ5205747
P304page(s)1459-1469
P577publication date2013-08-07
P1433published inDisease Models & MechanismsQ1524006
P1476titleModerate and high amounts of tamoxifen in αMHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death
P478volume6