CXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic mice

scientific article published on 23 June 2010

CXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.0903710
P932PMC publication ID3824617
P698PubMed publication ID20574003
P5875ResearchGate publication ID44698320

P2093author name stringPeggy L Kendall
Rachel A Henry
P2860cites workB cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissueQ24669900
A chemokine-driven positive feedback loop organizes lymphoid folliclesQ28142202
Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD miceQ34035323
Vkappa polymorphisms in NOD mice are spread throughout the entire immunoglobulin kappa locus and are shared by other autoimmune strainsQ34267403
Activation of Rheumatoid Factor (RF) B Cells and Somatic Hypermutation Outside of Germinal Centers in Autoimmune‐Prone MRL/lpr MiceQ35119889
Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptorQ36369174
A critical role for lymphotoxin-beta receptor in the development of diabetes in nonobese diabetic miceQ36369177
Lymphoid neogenesis in chronic inflammatory diseases.Q36405080
BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis.Q41740089
Anti-chromatin antibodies drive in vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sitesQ42206660
Th1-biased tertiary lymphoid tissue supported by CXC chemokine ligand 13-producing stromal network in chronic lesions of autoimmune gastritis.Q42451126
Tertiary lymphoid structures in the pancreas promote selection of B lymphocytes in autoimmune diabetesQ42617543
Multiple germline kappa light chains generate anti-insulin B cells in nonobese diabetic miceQ42661803
Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5.Q44999948
Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis.Q51027456
Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjögren's syndromeQ60810881
Systematic microanatomical analysis of CXCL13 and CCL21in situ production and progressive lymphoid organization in rheumatoid synovitisQ60810884
Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: a longitudinal studyQ67298313
Lymphoid neogenesis in rheumatoid synovitisQ74147962
B cell specificity contributes to the outcome of diabetes in nonobese diabetic miceQ77136854
Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjögren's syndromeQ77179303
Mature antigen-experienced T helper cells synthesize and secrete the B cell chemoattractant CXCL13 in the inflammatory environment of the rheumatoid jointQ79765411
Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structureQ80171529
Peritoneal B cells govern the outcome of diabetes in non-obese diabetic miceQ80442791
CXC chemokine ligand 13 plays a role in experimental autoimmune encephalomyelitisQ83918246
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectlymphocyteQ715347
biasQ742736
tertiary lymphoid structureQ54928327
P304page(s)1460-1465
P577publication date2010-06-23
P1433published inJournal of ImmunologyQ3521441
P1476titleCXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic mice
P478volume185

Reverse relations

cites work (P2860)
Q50882786A distinct human CD4+ T cell subset that secretes CXCL13 in rheumatoid synovium.
Q55038717A novel approach to improve immune effector responses post transplant by restoration of CCL21 expression.
Q99711793Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?
Q37238275CXCL13 is elevated in Sjögren's syndrome in mice and humans and is implicated in disease pathogenesis
Q91596260Circulating CXCR5-PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes
Q26799117Control of CD8 T-Cell Infiltration into Tumors by Vasculature and Microenvironment
Q28071695Development and Function of Secondary and Tertiary Lymphoid Organs in the Small Intestine and the Colon
Q40557011Early IL-1 Signaling Promotes iBALT Induction after Influenza Virus Infection
Q26778348Ectopic lymphoid follicles: inducible centres for generating antigen-specific immune responses within tissues
Q38221815Ectopic lymphoid-like structures in infection, cancer and autoimmunity
Q38091729Effects of CXCL13 inhibition on lymphoid follicles in models of autoimmune disease
Q38939468IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung
Q26742160Inducible Bronchus-Associated Lymphoid Tissue: Taming Inflammation in the Lung
Q37469720Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8+ T cells
Q42128925Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice
Q37729359Regulatory B cells in autoimmune diseases
Q49123591Role of CXCL13 in cigarette smoke-induced lymphoid follicle formation and chronic obstructive pulmonary disease
Q37548717Severe clinical presentation of visceral leishmaniasis in naturally infected dogs with disruption of the splenic white pulp.
Q35597162T cell-driven initiation and propagation of autoimmune diabetes
Q36260514Targeting Anti-Insulin B Cell Receptors Improves Receptor Editing in Type 1 Diabetes-Prone Mice
Q38012568Tertiary lymphoid organs in infection and autoimmunity
Q39201665Tertiary lymphoid organs in systemic autoimmune diseases:  pathogenic or protective?
Q26776542The Ins and Outs of B Cells in Multiple Sclerosis
Q35104199The lymphoid chemokine, CXCL13, is dispensable for the initial recruitment of B cells to the acutely inflamed central nervous system
Q38728631The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy
Q36838604Tolerant anti-insulin B cells are effective APCs

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