Targeting the progression of Parkinson's disease.

scientific article published on March 2009

Targeting the progression of Parkinson's disease. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2174/157015909787602814
P932PMC publication ID2724666
P698PubMed publication ID19721815
P5875ResearchGate publication ID26781443

P50authorSimon WilkinsQ55537273
Ashley I. BushQ39880503
P2093author name stringJ L George
S Mok
D I Finkelstein
R A Cherny
D Moses
P2860cites workChronic Parkinsonism in humans due to a product of meperidine-analog synthesisQ22242250
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligaseQ22254584
A role for alpha-synuclein in the regulation of dopamine biosynthesisQ24293727
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stabilityQ24299939
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesisQ24304952
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonismQ24309753
Hereditary early-onset Parkinson's disease caused by mutations in PINK1Q24337084
Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36.Q24535854
Relation between aluminum concentrations in drinking water and Alzheimer's disease: an 8-year follow-up studyQ24644989
Occupational exposures to solvents and aluminium and estimated risk of Alzheimer's diseaseQ24672121
Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27Q24680250
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's modelsQ24683059
Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synucleinQ26269955
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPaseQ27649733
Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseasesQ27740782
Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding siteQ27765365
Mutation in the alpha-synuclein gene identified in families with Parkinson's diseaseQ27860459
alpha-Synuclein locus triplication causes Parkinson's diseaseQ27860533
Alpha-synuclein in Lewy bodiesQ27860680
Staging of brain pathology related to sporadic Parkinson's diseaseQ28131702
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathologyQ28131833
Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson diseaseQ28187904
Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquatQ28215248
Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factorQ28237467
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's diseaseQ28292932
Mapping of a gene for Parkinson's disease to chromosome 4q21-q23Q28295005
Improvement of abnormal pyruvate metabolism and cardiac conduction defect with coenzyme Q10 in Kearns-Sayre syndromeQ28307882
Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's diseaseQ28317593
"On-off" effects in patients with Parkinson's disease on chronic levodopa therapyQ28317866
Influence of neuromelanin on oxidative pathways within the human substantia nigraQ34802086
Techniques for gene transfer into neurons.Q34942440
Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and agingQ34944292
Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brainQ35000819
Neural transplantation for the treatment of Parkinson's diseaseQ35172255
Parkinson's disease: is the initial treatment established?Q35203983
Long-term follow up of bilateral deep brain stimulation of the subthalamic nucleus in patients with advanced Parkinson diseaseQ35213394
Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulationQ35490116
The origin of motor fluctuations in Parkinson's disease: importance of dopaminergic innervation and basal ganglia circuits.Q35626716
Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse modelQ35747138
The relevance of iron in the pathogenesis of Parkinson's disease.Q35754511
A critical review of the development and importance of proteinaceous aggregates in animal models of Parkinson's disease: new insights into Lewy body formationQ35761478
Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neuronsQ35786982
Metals in our minds: therapeutic implications for neurodegenerative disordersQ35811065
Placebo mechanisms and reward circuitry: clues from Parkinson's disease.Q35825195
Superoxide accelerates DNA damage by elevating free-iron levelsQ35921515
Regional dissection and determination of loosely bound and non-heme iron in the developing mouse brainQ35962705
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned model of parkinson's disease, with emphasis on mice and nonhuman primates.Q35969693
Is levodopa toxic?Q36022114
Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connectionQ36160457
PINK1 mutation heterozygosity and the risk of Parkinson's diseaseQ36227281
Imaging of calcium and aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of GuamQ36256318
Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's diseaseQ36288717
Prospective study of dietary pattern and risk of Parkinson diseaseQ36426202
The neurotoxicity of amphetamines: bridging drugs of abuse and neurodegenerative disorders.Q36469891
A new look at levodopa based on the ELLDOPA studyQ36611595
Complex I, iron, and ferritin in Parkinson's disease substantia nigraQ36730657
Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal gangliaQ36739461
NACP, a protein implicated in Alzheimer's disease and learning, is natively unfoldedQ36830682
In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange stainingQ36857701
Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra.Q36880531
A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease.Q36880536
Alterations in the distribution of glutathione in the substantia nigra in Parkinson's diseaseQ36895132
Redox imbalance in Parkinson's diseaseQ36899782
Aluminum but not iron treatment induces pro-oxidant events in the rat brainQ41664962
Measuring the rate of progression and estimating the preclinical period of Parkinson's disease with [18F]dopa PET.Q41953550
Decreased ferritin levels in brain in Parkinson's diseaseQ42000755
Pigmentation in the nucleus substantiae nigrae of mammals.Q42112197
Copper(II)-induced self-oligomerization of alpha-synuclein.Q42158800
Comparative resistance of the 20S and 26S proteasome to oxidative stress.Q42159087
Effects of flavonoids on Naja naja and human recombinant synovial phospholipases A2 and inflammatory responses in mice.Q42285800
Neuroferritinopathy: a window on the role of iron in neurodegeneration.Q42436187
Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in ratsQ42436464
Cellular distribution of transferrin, ferritin, and iron in normal and aged human brainsQ42477389
Role of striatal L-DOPA in the production of dyskinesia in 6-hydroxydopamine lesioned rats.Q42492136
Aluminum-induced neurofibrillary degeneration affects a subset of neurons in rabbit cerebral cortex, basal forebrain and upper brainstemQ42498358
Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutationQ42501526
Pathophysiology of L-dopa-induced abnormal involuntary movementsQ42507094
An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.Q42524820
Chronic low-Ca/Mg high-Al diet induces neuronal lossQ42527569
Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.Q42617687
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloidQ42620617
Exposure to aluminium and the subsequent development of a disorder with features of Alzheimer's diseaseQ42765223
Genetic analysis of families with Parkinson disease that carry the Ala53Thr mutation in the gene encoding alpha-synucleinQ43218554
Water quality has a pronounced effect on cholesterol-induced accumulation of Alzheimer amyloid beta (Abeta) in rabbit brain.Q43359935
Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers.Q43619529
Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's diseaseQ43624453
Development of potential iron chelators for the treatment of Friedreich's ataxia: ligands that mobilize mitochondrial ironQ43640204
Failure to find a relationship between mnestic skills of octogenarians and aluminum in drinking waterQ43646719
Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's diseaseQ43668015
6-hydroxydopamine-induced nuclear factor-kappa B activation in PC12 cells.Q43670369
A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese populationQ43727689
Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegenerationQ43735211
Nitration and inactivation of tyrosine hydroxylase by peroxynitriteQ43759048
The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synucleinQ43798526
Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal culturesQ43832105
Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphismsQ43849066
Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic cultureQ43868527
Effects of aluminum and zinc on the oxidative stress caused by 6-hydroxydopamine autoxidation: relevance for the pathogenesis of Parkinson's disease.Q43963316
Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic culturesQ44027697
Proteasome inhibition causes nigral degeneration with inclusion bodies in ratsQ44094584
Homozygous deletions in parkin gene in European and North African families with autosomal recessive juvenile parkinsonism. The European Consortium on Genetic Susceptibility in Parkinson's Disease and the French Parkinson's Disease Genetics Study GroQ44182363
Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in ratsQ44183832
Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk.Q44187776
Vitamin E supplements fail to protect mice from acute MPTP neurotoxicity.Q44215292
Aggresome-related biogenesis of Lewy bodiesQ44242992
Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.Q44264439
Altered proteasomal function in sporadic Parkinson's diseaseQ44264446
Neurotoxic effects of aluminium among foundry workers and Alzheimer's diseaseQ44273876
Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's diseaseQ44386905
Cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons.Q44396203
Movement disorders in the Hfe knockout mouseQ44452286
Adult nutrient intake as a risk factor for Parkinson's diseaseQ44487546
Manganese, copper, and zinc in cerebrospinal fluid from patients with multiple sclerosisQ44497674
Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modificationsQ44511146
A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's diseaseQ44571920
Genetic analysis of LRRK2 mutations in patients with Parkinson diseaseQ46857317
Effects of pallidotomy on motor symptoms in an animal model of Parkinson's diseaseQ46889281
Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficitsQ47072826
Dopamine D2-type agonists protect mesencephalic neurons from glutamate neurotoxicity: mechanisms of neuroprotective treatment against oxidative stress.Q47831483
UCHL1 is a Parkinson's disease susceptibility geneQ47866612
The ubiquitin pathway in Parkinson's diseaseQ48015939
Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implicationsQ48088787
Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress.Q48144142
Peroxynitrite induces tryosine nitration and modulates tyrosine phosphorylation of synaptic proteinsQ48148974
Iron and other metals in neuromelanin, substantia nigra, and putamen of human brainQ48164667
Histochemical and X-ray microanalytical localization of aluminum in amyotrophic lateral sclerosis and parkinsonism-dementia of GuamQ48167005
Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson diseaseQ48168351
Alpha-tocopherol and beta-carotene do not protect marmosets against the dopaminergic neurotoxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridineQ48189797
High dose levodopa therapy is not toxic in multiple system atrophy: experimental evidenceQ48207785
MRI evaluation of brain iron in earlier- and later-onset Parkinson's disease and normal subjectsQ48228911
Monoamine oxidase, hydrogen peroxide, and Parkinson's disease.Q48254031
Biochemical pathophysiology of Parkinson's disease.Q48258284
Expression of ferritin protein and subunit mRNAs in normal and iron deficient rat brainQ48270964
Brain iron in the rat: extremely slow turnover in normal rats may explain long-lasting effects of early iron deficiencyQ48288693
Chronic rotenone treatment induces behavioral effects but no pathological signs of parkinsonism in miceQ48336800
Unilateral subthalamotomy in the treatment of Parkinson's diseaseQ48338772
Total and paramagnetic metals in human substantia nigra and its neuromelaninQ48367595
Growth of transplanted monoaminergic neurones into the adult hippocampus along the perforant pathQ48369614
Nigrostriatal damage with 6-OHDA: validation of routinely applied proceduresQ48369923
Oral administration of metal chelator ameliorates motor dysfunction after a small hemorrhage near the internal capsule in rat.Q48388799
Possible regeneration of gamma-aminobutyric acid-containing fibres into irides transplanted into the central nervous systemQ48402514
M30, a novel multifunctional neuroprotective drug with potent iron chelating and brain selective monoamine oxidase-ab inhibitory activity for Parkinson's disease.Q48405800
Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA studyQ48419227
Role of manganese in dystoniaQ48419648
Iron- and manganese-catalyzed autoxidation of dopamine in the presence of L-cysteine: possible insights into iron- and manganese-mediated dopaminergic neurotoxicityQ48427127
Ascorbic acid reduces the dopamine depletion induced by MPTP.Q48432320
Effects of chronic methamphetamine on the nigral-striatal dopamine system in rat brain: tyrosine hydroxylase immunochemistry and quantitative light microscopic studiesQ48434326
Postnatal iron overload destroys NA-DA functional interactionsQ48437217
Actions of 6-hydroxydopamine quinones on catecholamine neuronsQ48438065
Gastrointestinal absorption of aluminium and citrate in man.Q48448209
Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration.Q48449992
Pergolide scavenges both hydroxyl and nitric oxide free radicals in vitro and inhibits lipid peroxidation in different regions of the rat brainQ48450630
Lack of up-regulation of ferritin is associated with sustained iron regulatory protein-1 binding activity in the substantia nigra of patients with Parkinson's diseaseQ48450930
Partial protection from the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by four different antioxidants in the mouseQ48452041
Uptake and distribution of iron and transferrin in the adult rat brain.Q48459489
Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivityQ48463677
PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat modelQ48465219
Aluminium salts accelerate peroxidation of membrane lipids stimulated by iron saltsQ48468985
Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged miceQ48482071
Levels of alpha-synuclein mRNA in sporadic Parkinson disease patientsQ48489167
4-hydroxynonenal, a lipid peroxidation product, impairs glutamate transport in cortical astrocytes.Q48490623
Increasing striatal iron content associated with normal agingQ48491547
Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and ironQ48491695
Genetic vitamin E deficiency does not affect MPTP susceptibility in the mouse brainQ48492232
Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age.Q48502457
The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicityQ64777142
Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patientsQ64778242
Microstimulation-induced inhibition of neuronal firing in human globus pallidusQ64779027
Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's diseaseQ64821269
Synthetic carotenoids, novel polyene polyketones and new capsorubin isomers as efficient quenchers of singlet molecular oxygenQ68188283
Immunological and biochemical studies and pilot therapeutic trial with ubidecarenone in Kearns-Sayre patientsQ68247909
Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxideQ68255434
Clinical and biochemical correlations in mitochondrial myopathies treated with coenzyme Q10Q68352956
Monoamine oxidase and oxidative stress at dopaminergic synapsesQ68382268
Positron emission tomography in manganese intoxicationQ69248608
Comparison of the regional distribution of transferrin receptors and aluminium in the forebrain of chronic renal dialysis patientsQ69429374
Role of dopamine in manganese neurotoxicityQ69850146
Induction of DNA breakage and suppression of DNA synthesis by the OH radical generated in a Fenton-like reactionQ70139579
A brainstem atlas of catecholaminergic neurons in man, using melanin as a natural markerQ70765260
Mechanism of in vivo iron chelation by pyridoxal isonicotinoyl hydrazone and other imino derivatives of pyridoxalQ70831530
Dietary lipids and antioxidants in Parkinson's disease: a population-based, case-control studyQ70928225
4-Hydroxynonenal triggers Ca2+ influx in isolated rat hepatocytesQ70946276
Mapping of the gracile axonal dystrophy (gad) gene to a region between D5Mit197 and D5Mit113 on proximal mouse chromosome 5Q71739707
Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidantsQ71778889
Lipid peroxidation and changes in the ubiquinone content and the respiratory chain enzymes of submitochondrial particlesQ71939401
The correlation between active oxygens scavenging and antioxidative effects of flavonoidsQ72150971
Relations between tocopherol depletion and coenzyme Q during lipid peroxidation in rat liver mitochondriaQ72177081
Intranigral injected iron progressively reduces striatal dopamine metabolismQ72232437
Bromocriptine scavenges methamphetamine-induced hydroxyl radicals and attenuates dopamine depletion in mouse striatumQ72438789
Activated oxygen species at the origin of chromosome breakage and sister-chromatid exchangesQ72921258
MR evaluation of age-related increase of brain iron in young adult and older normal malesQ73184477
Antioxidant and prooxidant behavior of flavonoids: structure-activity relationshipsQ73268875
Role of oxidative stress in the manganese and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced apoptosis in PC12 cellsQ73504495
Absorption of aluminium-26 in Alzheimer's disease, measured using accelerator mass spectrometryQ73516357
Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathiesQ73626218
Impaired proteasome function in Alzheimer's diseaseQ73897101
Oligodendrocyte progenitor cells internalize ferritin via clathrin-dependent receptor mediated endocytosisQ73911882
Axonal sprouting following lesions of the rat substantia nigraQ73947220
Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's diseaseQ74016935
Neuropathology in mice expressing human alpha-synucleinQ74139704
Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residuesQ74248716
Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat modelQ28344741
Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout miceQ28505777
Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridineQ28510205
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in miceQ28510424
alpha-Synuclein produces a long-lasting increase in neurotransmitter releaseQ28510893
Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synucleinQ28511573
Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in miceQ28588544
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neuronsQ28590748
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.Q28593258
Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoidsQ28609442
Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of dataQ28943545
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementiaQ29547174
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagyQ29614178
Alpha-synuclein locus duplication as a cause of familial Parkinson's diseaseQ29614762
Chronic systemic pesticide exposure reproduces features of Parkinson's diseaseQ29614763
Why are "natively unfolded" proteins unstructured under physiologic conditions?Q29615739
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by ParkinQ29617063
Transplantation of embryonic dopamine neurons for severe Parkinson's diseaseQ29617304
Oxidative stress and neurodegeneration: where are we now?Q29617324
Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranesQ29617606
The 26S proteasome: a molecular machine designed for controlled proteolysisQ29619692
The E46K mutation in alpha-synuclein increases amyloid fibril formation.Q30349931
Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad miceQ30764264
L-DOPA-induced dyskinesia in the intrastriatal 6-hydroxydopamine model of parkinson's disease: relation to motor and cellular parameters of nigrostriatal functionQ30837835
Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adductQ31029246
Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synucleinQ31120123
Delivery of a GDNF gene into the substantia nigra after a progressive 6-OHDA lesion maintains functional nigrostriatal connectionsQ31457974
Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insultQ31961798
Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in miceQ33215982
Antioxidants protect PINK1-dependent dopaminergic neurons in DrosophilaQ33255660
Review of the therapeutic management of Parkinson's disease. Report of a joint task force of the European Federation of Neurological Societies and the Movement Disorder Society-European Section. Part I: early (uncomplicated) Parkinson's diseaseQ33260250
Review of the therapeutic management of Parkinson's disease. Report of a joint task force of the European Federation of Neurological Societies (EFNS) and the Movement Disorder Society-European Section (MDS-ES). Part II: late (complicated) Parkinson'Q33260251
Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal gangliaQ33322579
Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's diseaseQ33323265
Motor response to acute dopaminergic challenge with apomorphine and levodopa in Parkinson's disease: implications for the pathogenesis of the on-off phenomenonQ33735320
Evaluation of surgery for Parkinson's disease: a report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. The Task Force on Surgery for Parkinson's DiseaseQ33795694
Effects on the nervous system among welders exposed to aluminium and manganeseQ33819551
Environmental exposure to trace elements and risk of amyotrophic lateral sclerosis: a population-based case-control studyQ74477216
Effect of plant flavonoids on immune and inflammatory cell functionQ77440716
Induction of DNA strand breakage and base oxidation by nitroxyl anion through hydroxyl radical productionQ77919964
Aluminum enhances melanin-induced lipid peroxidationQ78230739
Toward identification of susceptibility genes for sporadic Parkinson's diseaseQ79209570
DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonismQ79249169
A common A340T variant in PINK1 gene associated with late-onset Parkinson's disease in ChineseQ79329781
Levodopa slows progression of Parkinson's disease: external validation by clinical trial simulationQ79796313
The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive elementQ79838827
CuZn-SOD deficiency causes ApoB degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in miceQ80142989
Case-control study of UCHL1 S18Y variant in Parkinson's diseaseQ80187773
Alpha-synuclein overexpression increases cytosolic catecholamine concentrationQ80223133
Causal relation between alpha-synuclein gene duplication and familial Parkinson's diseaseQ80794093
Levodopa and the progression of Parkinson's diseaseQ81595933
Selegiline slows the progression of the symptoms of Parkinson diseaseQ82843497
Differential involvement of mitochondrial permeability transition in cytotoxicity of 1-methyl-4-phenylpyridinium and 6-hydroxydopamineQ83178182
Striatal FP-CIT uptake differs in the subtypes of early Parkinson's diseaseQ48529629
Bilateral pallidotomy in Parkinson's disease: a retrospective studyQ48552730
Distribution of paraquat into the brain after its systemic injection in rats.Q48563982
Glutathione deficiency potentiates manganese toxicity in rat striatum and brainstem and in PC12 cells.Q48566534
Intranuclear aluminum accumulation in chronic animals with experimental neurofibrillary changesQ48648073
Iron deposits in multiple sclerosis and Alzheimer's disease brainsQ48682014
Can cocaine abuse cause parkinsonism?Q48739953
Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's diseaseQ48774077
Intracerebral grafting of neuronal cell suspensions. II. Survival and growth of nigral cell suspensions implanted in different brain sites.Q48828178
Intracerebral grafting of neuronal cell suspensions. VIII. Survival and growth of implants of nigral and septal cell suspensions in intact brains of aged ratsQ48828185
Intracerebral grafting of neuronal cell suspensions. VII. Recovery of choline acetyltransferase activity and acetylcholine synthesis in the denervated hippocampus reinnervated by septal suspension implantsQ48828193
Intracerebral grafting of neuronal cell suspensions. VI. Survival and growth of intrahippocampal implants of septal cell suspensionsQ48828203
Intracerebral grafting of neuronal cell suspensions. I. Introduction and general methods of preparation.Q48828219
Intracerebral grafting of neuronal cell suspensions. V. Behavioural recovery in rats with bilateral 6-OHDA lesions following implantation of nigral cell suspensionsQ48829640
Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's diseaseQ48830095
Treatment of mice with methamphetamine produces cell loss in the substantia nigraQ48887098
Diet and Parkinson's disease. I: A possible role for the past intake of specific foods and food groups. Results from a self-administered food-frequency questionnaire in a case-control studyQ48935400
Neonatal iron potentiates adult MPTP-induced neurodegenerative and functional deficitsQ48952359
Correspondence of melanin-pigmented neurons in human brain with A1-A14 catecholamine cell groupsQ48973700
Variations in dietary iron alter behavior in developing ratsQ49069501
Influence of age on the passage of paraquat through the blood-brain barrier in rats: a distribution and pathological examinationQ49075919
Neurobehavioral dysfunctions associated with dietary iron overloadQ49129846
Stimulation of the subthalamic nucleus in a patient with Parkinson disease and essential tremorQ49157981
The natural history of neurological manganism over 18 yearsQ50277880
Dietary iron, animal fats, and risk of Parkinson's disease.Q50884333
Dietary antioxidants and Parkinson disease. The Rotterdam Study.Q50950498
EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION. I. LIGHT MICROSCOPIC OBSERVATIONSQ51253309
Disease progression and pharmacodynamics in Parkinson disease - evidence for functional protection with levodopa and other treatments.Q51943432
Dietary antioxidants and other dietary factors in the etiology of Parkinson's disease.Q52003162
Cognitive deficits in iron-deficient and iron-deficient anemic children.Q52078963
Inactivation of dehydratase [4Fe-4S] clusters and disruption of iron homeostasis upon cell exposure to peroxynitrite.Q52527681
Membrane binding and self-association of alpha-synucleins.Q52543652
Aluminum exposure and risk of Alzheimer disease.Q53223016
Aluminum forms in drinking water and risk of Alzheimer's disease.Q53343948
Mechanism for manganese enhancement of dopamine-induced oxidative DNA damage and neuronal cell death.Q53606465
The role of pathogenic DJ-1 mutations in Parkinson's disease.Q54757155
Parkinson's diseaseQ56877819
3-Hydroxykynurenine and 3-Hydroxyanthranilic Acid Generate Hydrogen Peroxide and Promote α-Crystallin Cross-Linking by Metal Ion Reduction†Q57080763
The iron-responsive element is the single element responsible for iron-dependent translational regulation of ferritin biosynthesis. Evidence for function as the binding site for a translational repressorQ57397579
Copper- and iron-induced differential fibril formation in α-synuclein: TEM studyQ57459956
Thermodynamics imprinting reveals differential binding of metals to α-synuclein: Relevance to parkinson’s diseaseQ57459960
A heterozygous effect for PINK1 mutations in Parkinson's disease?Q58617948
Functional reactivation of the deafferented neostriatum by nigral transplantsQ59067439
Degeneration of the centré median-parafascicular complex in Parkinson's diseaseQ59544666
Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brainQ61714016
Parkinson's disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridineQ64764588
An autopsy case of autosomal-recessive juvenile parkinsonism with a homozygous exon 4 deletion in the parkin gene.Q64768245
No tissue damage by chronic deep brain stimulation in Parkinson's diseaseQ64770078
Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson diseaseQ37671552
DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitriteQ37700756
Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's diseaseQ37713838
Carotenoids, tocopherols and thiols as biological singlet molecular oxygen quenchersQ37796068
Role of catechol autooxidation in the degeneration of dopamine neuronsQ37971848
Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone: protective effect of coenzyme Q10.Q38514050
Dietary factors in Parkinson's disease: the role of food groups and specific foodsQ38547790
Influence of methamphetamine on nigral and striatal tyrosine hydroxylase activity and on striatal dopamine levelsQ39097283
Presynaptic and postsynaptic striatal dopaminergic function in patients with manganese intoxication: a positron emission tomography studyQ39114810
Hereditary form of parkinsonism--dementiaQ39116097
Efficacy of bilateral subthalamic nucleus (STN) stimulation in Parkinson's diseaseQ39359246
Success and problems of long-term levodopa therapy in Parkinson's diseaseQ39419773
MPTP-induced deficits in striatal synaptic plasticity are prevented by glial cell line-derived neurotrophic factor expressed via an adeno-associated viral vector.Q40095787
Therapeutic targets and potential of the novel brain- permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's diseaseQ40201129
RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport.Q40203572
GDNF reduces oxidative stress in a 6-hydroxydopamine model of Parkinson's diseaseQ40204577
Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes.Q40216832
Parkin affects mitochondrial function and apoptosis in neuronal and myogenic cellsQ40244264
Clioquinol and docosahexaenoic acid act synergistically to kill tumor cells.Q40246736
GDNF in Parkinson disease: an object lesson in the tyranny of type II.Q40250019
Androgen and anti-androgen treatment modulates androgen receptor activity and DJ-1 stabilityQ40284570
Influence of different promoters on the expression pattern of mutated human alpha-synuclein in transgenic mice.Q40297921
Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat modelQ40320292
Silencing of human alpha-synuclein in vitro and in rat brain using lentiviral-mediated RNAiQ40321534
Parkin enhances mitochondrial biogenesis in proliferating cellsQ40322753
Clinical trials with rasagiline: evidence for short-term and long-term effectsQ40323136
The pathogenesis of cell death in Parkinson's diseaseQ40323146
Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson diseaseQ40326219
6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase CdeltaQ40339108
Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insultsQ40380055
Role of RNA secondary structure of the iron-responsive element in translational regulation of ferritin synthesisQ40396368
Effect of AdGDNF on dopaminergic neurotransmission in the striatum of 6-OHDA-treated ratsQ40427208
Anticancer activity of the antibiotic clioquinolQ40434343
Delayed gene therapy of glial cell line-derived neurotrophic factor is efficacious in a rat model of Parkinson's diseaseQ40442685
Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localizationQ40442695
Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10.Q40449016
Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation.Q40524258
Effects of 6-hydroxydopamine on primary cultures of substantia nigra: specific damage to dopamine neurons and the impact of glial cell line-derived neurotrophic factorQ40566456
Oxidative stress regulated genes in nigral dopaminergic neuronal cells: correlation with the known pathology in Parkinson's diseaseQ40672194
Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's diseaseQ40694627
Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell lineQ40714967
Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's diseaseQ40737427
Pro-inflammatory effects of aluminum in human glioblastoma cellsQ40740789
Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cellsQ40789736
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's diseaseQ40795664
Glial cell line-derived neurotrophic factor (GDNF) gene delivery protects dopaminergic terminals from degenerationQ40811477
The causes of Parkinson's disease are being unraveled and rational neuroprotective therapy is close to realityQ40842068
Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicityQ40844291
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's diseaseQ40846012
Immortalized dopamine neurons: A model to study neurotoxicity and neuroprotectionQ40918411
Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's diseaseQ40929764
Neuroprotection by pramipexole against dopamine- and levodopa-induced cytotoxicityQ40956717
Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregationQ40964871
Identification and characterization of a novel protein that regulates RNA-protein interactionQ40972571
The lipid peroxidation product 4-hydroxynonenal impairs glutamate and glucose transport and choline acetyltransferase activity in NSC-19 motor neuron cellsQ40978148
Glial cell line-derived neurotrophic growth factor inhibits apoptotic death of postnatal substantia nigra dopamine neurons in primary cultureQ41021656
Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokinesQ41059727
Gastrointestinal absorption of aluminium in Alzheimer's disease: response to aluminium citrate.Q41117220
The history of iron in the brainQ41144685
Unilateral 6-hydroxydopamine lesions of meso-striatal dopamine neurons and their physiological sequelaeQ41173089
Efficient transduction of human neurons with an adeno-associated virus vectorQ41222907
Selective vulnerability of glutathione metabolism and cellular defense mechanisms in rat striatum to manganese.Q41347591
Case-control study of early life dietary factors in Parkinson's diseaseQ41405298
Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of GuamQ41624368
Iron in the basal ganglia in Parkinson's disease. An in vitro study using extended X-ray absorption fine structure and cryo-electron microscopyQ41632791
Intron-exon structure of ubiquitin c-terminal hydrolase-L1.Q33853339
Low frequency of pathogenic mutations in the ubiquitin carboxy-terminal hydrolase gene in familial Parkinson's diseaseQ33858726
Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles.Q33922930
Alzheimer disease beta-amyloid activity mimics cholesterol oxidaseQ33925332
Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysisQ34020005
Preclinical (premotor) Parkinson's diseaseQ34035624
Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson diseaseQ34049606
Pathophysiology of the basal ganglia in Parkinson's disease.Q34070859
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.Q34082498
Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.Q34086208
Impaired iron homeostasis in Parkinson's disease.Q34155212
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibilityQ34157005
Histochemical observations on rodent brain melaninQ34264554
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trialQ34283745
Metabolism and function of coenzyme Q.Q34294224
In vivo generation of hydroxyl radicals and MPTP-induced dopaminergic toxicity in the basal ganglia.Q34316878
Aluminium as a risk factor in Alzheimer's disease, with emphasis on drinking waterQ34317933
Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's diseaseQ34331409
Identification of two distinct synucleins from human brainQ34341909
Novel PINK1 mutations in early-onset parkinsonismQ34345898
Progression after chronic manganese exposureQ34352765
Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's diseaseQ34358956
Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP.Q34361701
Analysis of the PINK1 gene in a large cohort of cases with Parkinson diseaseQ34376115
Aluminum concentrations in drinking water and risk of Alzheimer's diseaseQ34422708
Long-term progression in chronic manganism: ten years of follow-upQ34461867
Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional declineQ34528059
Functional effects of neuromelanin and synthetic melanin in model systems.Q34534985
Pesticide exposure and risk for Parkinson's diseaseQ34542115
Levodopa and the progression of Parkinson's diseaseQ34553278
Therapeutic effects of coenzyme Q10 (CoQ10) and reduced CoQ10 in the MPTP model of Parkinsonism.Q34584417
Diet and Parkinson's disease. II: A possible role for the past intake of specific nutrients. Results from a self-administered food-frequency questionnaire in a case-control studyQ34734597
???Q64767196
???Q64782380
???Q64786912
???Q64867043
???Q64976807
Timecourse of striatal re-innervation following lesions of dopaminergic SNpc neurons of the rat.Q44574098
Do patients with Parkinson?s disease benefit from embryonic dopamine cell transplantation?Q44632473
Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's diseaseQ44653423
Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in ratsQ44697081
How does Parkinson's disease begin? The role of compensatory mechanisms.Q44809582
Autoxidation and MAO-mediated metabolism of dopamine as a potential cause of oxidative stress: role of ferrous and ferric ions.Q44843169
Intranigral iron injection induces behavioral and biochemical "parkinsonism" in ratsQ44848373
Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28.Q44856789
A perspective on transplantation therapy and stem cells for Parkinson's diseaseQ44931899
Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloidQ44961994
L-DOPA reverses the hypokinetic behaviour and rigidity in rotenone-treated ratsQ44987162
Lipid rafts mediate the synaptic localization of alpha-synuclein.Q44999245
Inhibition of proteasome activity sensitizes dopamine neurons to protein alterations and oxidative stressQ45104002
Similarities between methamphetamine toxicity and proteasome inhibition.Q45149968
PCTH: a novel orally active chelator of the aroylhydrazone class that induces iron excretion from mice.Q45192666
Prevalence of parkinsonism and relationship to exposure in a large sample of Alabama weldersQ45236735
Subthalamic stimulation activates internal pallidus: evidence from cGMP microdialysis in PD patients.Q45283166
"Levodopa phobia": a new iatrogenic cause of disability in Parkinson diseaseQ45309188
Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine.Q45711545
Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vectorQ45769447
Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson's diseaseQ45881923
Iron deprivation during fetal development changes the behavior of juvenile rhesus monkeysQ46064657
Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicityQ46070812
Evidence for a partially folded intermediate in alpha-synuclein fibril formationQ46097239
MPTP toxicity in the mouse brain and vitamin E.Q46306995
Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration.Q46377129
Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures.Q46404063
Occurrence of neuronal inclusions combined with increased nigral expression of alpha-synuclein within dopaminergic neurons following treatment with amphetamine derivatives in miceQ46440075
Haloperidol treatment reverses behavioural and anatomical changes in cocaine-dependent miceQ46443518
Histological, behavioural and neurochemical evaluation of medial forebrain bundle and striatal 6-OHDA lesions as rat models of Parkinson's diseaseQ46452329
Role of oxidative stress in paraquat-induced dopaminergic cell degeneration.Q46460372
Acute or repeated cocaine administration generates reactive oxygen species and induces antioxidant enzyme activity in dopaminergic rat brain structuresQ46460578
Postural changes after lesions of the substantia nigra pars reticulata in hemiparkinsonian monkeys.Q46465349
Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathwayQ46537593
Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degenerationQ46541429
Hydrophobicity as the signal for selective degradation of hydroxyl radical-modified hemoglobin by the multicatalytic proteinase complex, proteasomeQ46557220
Sprouting of dopamine terminals and altered dopamine release and uptake in Parkinsonian dyskinaesia.Q46589894
A combinatorial code for the interaction of alpha-synuclein with membranesQ46601588
Regional distributions of manganese, iron, copper, and zinc in the brains of 6-hydroxydopamine-induced parkinsonian ratsQ46678106
Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseasesQ46682421
Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stressQ46684001
Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibitionQ46718285
Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletionQ46718289
A slowly developing dysfunction of dopaminergic nigrostriatal neurons induced by long-term paraquat administration in rats: an animal model of preclinical stages of Parkinson's disease?Q46725802
Structure-property studies on the antioxidant activity of flavonoids present in diet.Q46730721
Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction.Q46734652
Dityrosine and tyrosine oxidation products are endogenous markers for the selective proteolysis of oxidatively modified red blood cell hemoglobin by (the 19 S) proteasome.Q46736712
Neural activity controls the synaptic accumulation of alpha-synuclein.Q46832286
P433issue1
P921main subjectParkinson's diseaseQ11085
P304page(s)9-36
P577publication date2009-03-01
P1433published inCurrent NeuropharmacologyQ20181354
P1476titleTargeting the progression of Parkinson's disease
P478volume7

Reverse relations

cites work (P2860)
Q51764192Animal Toxins as Therapeutic Tools to Treat Neurodegenerative Diseases.
Q55049102Aqueous Extract of Dendropanax morbiferus Leaves Effectively Alleviated Neuroinflammation and Behavioral Impediments in MPTP-Induced Parkinson's Mouse Model.
Q26829742Cellular models to investigate biochemical pathways in Parkinson's disease
Q58715913Characteristics of the mitochondrial and cellular uptake of MPP+, as probed by the fluorescent mimic, 4'I-MPP
Q45873810Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments
Q26765787Is Modulation of Oxidative Stress an Answer? The State of the Art of Redox Therapeutic Actions in Neurodegenerative Diseases
Q38981601Mathematical models of α-synuclein transport in axons
Q26772733Melatonin and Other Tryptophan Metabolites Produced by Yeasts: Implications in Cardiovascular and Neurodegenerative Diseases
Q96953438Mismatch Negativity and Impaired Social Functioning in Long-Term and in First Episode Schizophrenia Spectrum Psychosis
Q37764793Mitochondrial dysfunction in neurodegenerative diseases and cancer
Q34184725Molecular imaging of cell death in an experimental model of Parkinson's disease with a novel apoptosis-targeting peptide
Q38111373NADPH oxidase and neurodegeneration
Q44593403Neuroprotective effect of aqueous extract of Selaginella delicatula as evidenced by abrogation of rotenone-induced motor deficits, oxidative dysfunctions, and neurotoxicity in mice
Q37825631Parkinson's disease dementia and potential therapeutic strategies
Q46952414Polygalasaponin F against rotenone-induced apoptosis in PC12 cells via mitochondria protection pathway
Q34398474Predictive association of copper metabolism proteins with Alzheimer's disease and Parkinson's disease: a preliminary perspective
Q36946543Selective brain penetrable Nurr1 transactivator for treating Parkinson's disease
Q30512976Sensorimotor assessment of the unilateral 6-hydroxydopamine mouse model of Parkinson's disease
Q33556006Staging neurodegenerative disorders: structural, regional, biomarker, and functional progressions
Q92406209The Ameliorative Effects of the Ethyl Acetate Extract of Salicornia europaea L. and Its Bioactive Candidate, Irilin B, on LPS-Induced Microglial Inflammation and MPTP-Intoxicated PD-Like Mouse Model
Q89509387The Potential Role of Astrocytes in Parkinson's Disease (PD)
Q41497337The effect of red grape juice and exercise, and their combination on parkinson(')s disease in rats
Q39063048The novel tetramethylpyrazine bis-nitrone (TN-2) protects against MPTP/MPP+-induced neurotoxicity via inhibition of mitochondrial-dependent apoptosis

Search more.