Identification of driver genes in hepatocellular carcinoma by exome sequencing

scientific article published on 24 September 2013

Identification of driver genes in hepatocellular carcinoma by exome sequencing is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/HEP.26540
P932PMC publication ID3830584
P698PubMed publication ID23728943
P5875ResearchGate publication ID237005025

P50authorGad GetzQ32646381
P2093author name stringKui Chen
Xiaobei Zhao
Michael C Wu
Michael S Lawrence
Derek Y Chiang
Scott Powers
Maha Guindi
Joel S Parker
Jinyu Li
Anand Ghanekar
Sean P Cleary
Gleb L Savich
Hyeja Kim
Sandra Fischer
Sara R Selitsky
Ting-Xu Tan
William R Jeck
P2860cites workExome sequencing of hepatitis B virus-associated hepatocellular carcinomaQ39290981
Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathwayQ39717064
Chromosome alterations in human hepatocellular carcinomas correlate with aetiology and histological grade--results of an explorative CGH meta-analysisQ41886998
Mixed lineage leukaemia-4 regulates cell-cycle progression and cell viability and its depletion suppresses growth of xenografted tumour in vivoQ42234071
Genome-wide survey of recurrent HBV integration in hepatocellular carcinomaQ44395085
Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma.Q46099165
Marked, homogeneous, and early [18F]fluorodeoxyglucose-positron emission tomography responses to vemurafenib in BRAF-mutant advanced melanoma.Q53168966
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in CancerQ24608391
Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinomaQ24609544
Initial genome sequencing and analysis of multiple myelomaQ24629117
Somatic mutations affect key pathways in lung adenocarcinomaQ24648102
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Fast gapped-read alignment with Bowtie 2Q27860699
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing dataQ27860742
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinomaQ27860881
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulatorsQ28267500
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing dataQ29547161
A framework for variation discovery and genotyping using next-generation DNA sequencing dataQ29547262
High-resolution characterization of a hepatocellular carcinoma genomeQ31005512
Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome dataQ33951424
Cancer gene discovery in hepatocellular carcinomaQ34002120
Sequence analysis of mutations and translocations across breast cancer subtypesQ34032470
Gene expression in fixed tissues and outcome in hepatocellular carcinoma.Q34235518
genenames.org: the HGNC resources in 2011.Q34456662
Mcl-1 overexpression in hepatocellular carcinoma: a potential target for antisense therapyQ34467880
Association of TP53 mutations with stem cell-like gene expression and survival of patients with hepatocellular carcinoma.Q34672668
A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4Q34980453
Targeted therapies for hepatocellular carcinoma.Q36928888
Focal gains of VEGFA and molecular classification of hepatocellular carcinomaQ36984575
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinomaQ37284612
Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cellsQ37321181
Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma.Q37777019
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolutionQ37830775
Strategies for hepatocellular carcinoma therapy and diagnostics: lessons learned from high throughput and profiling approaches.Q37857056
Genetics of hepatobiliary carcinogenesisQ37871482
Molecularly targeted therapy for advanced hepatocellular carcinoma in 2012: current status and future perspectivesQ38030783
P433issue5
P407language of work or nameEnglishQ1860
P921main subjecthepatocellular carcinomaQ1148337
P304page(s)1693-1702
P577publication date2013-09-24
P1433published inHepatologyQ15724398
P1476titleIdentification of driver genes in hepatocellular carcinoma by exome sequencing
P478volume58

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cites work (P2860)
Q398098679H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomain
Q28553513A Hybrid Chalcone Combining the Trimethoxyphenyl and Isatinyl Groups Targets Multiple Oncogenic Proteins and Pathways in Hepatocellular Carcinoma Cells
Q42064611A Surgical Perspective on Targeted Therapy of Hepatocellular Carcinoma
Q90862936A Survey of Molecular Heterogeneity in Hepatocellular Carcinoma
Q36935210A genomic case study of mixed fibrolamellar hepatocellular carcinoma
Q36134242Accumulation of Deleterious Passenger Mutations Is Associated with the Progression of Hepatocellular Carcinoma
Q39062813Action and function of Wnt/β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma
Q90961665Advancements in the Development of non-BET Bromodomain Chemical Probes
Q61451065Advances in genomic hepatocellular carcinoma research
Q64272351Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology
Q64227878Application of plasma circulating cell-free DNA detection to the molecular diagnosis of hepatocellular carcinoma
Q38788315Biological function and histone recognition of family IV bromodomain-containing proteins
Q33765935CRISPR/Cas9-mediated p53 and Pten dual mutation accelerates hepatocarcinogenesis in adult hepatitis B virus transgenic mice
Q47802066Camptothecin suppresses NRF2-ARE activity and sensitises hepatocellular carcinoma cells to anticancer drugs
Q59806022Cancer Metabolism as a Mechanism of Treatment Resistance and Potential Therapeutic Target in Hepatocellular Carcinoma
Q47128083Chemical probes and inhibitors of bromodomains outside the BET family
Q52597449Circulating Cell-Free DNA in Hepatocellular Carcinoma: Current Insights and Outlook.
Q92068298Circulating tumor DNA correlates with microvascular invasion and predicts tumor recurrence of hepatocellular carcinoma
Q88654160Circulating-free tumour DNA and the promise of disease phenotyping in hepatocellular carcinoma
Q38906201Clinical Outcomes of TP53 Mutations in Cancers
Q37373034Clinical implication of Keap1 and phosphorylated Nrf2 expression in hepatocellular carcinoma
Q37718221Clinical outcomes based on multigene profiling in metastatic breast cancer patients
Q59131869Clinical significance of APOB inactivation in hepatocellular carcinoma
Q58699543Comprehensive assessment for miRNA polymorphisms in hepatocellular cancer risk: a systematic review and meta-analysis
Q42107172Comprehensive characterization of hepatitis B virus-associated multifocal hepatocellular carcinoma using a multi-omics strategy
Q38329400Critical roles of non-histone protein lysine methylation in human tumorigenesis
Q64959827Current issues on genomic heterogeneity in hepatocellular carcinoma and its implication in clinical practice.
Q89767561DNA and RNA sequencing identified a novel oncogene VPS35 in liver hepatocellular carcinoma
Q35781255DNA markers in molecular diagnostics for hepatocellular carcinoma
Q37290515Detecting Circulating Tumor DNA in Hepatocellular Carcinoma Patients Using Droplet Digital PCR Is Feasible and Reflects Intratumoral Heterogeneity
Q92619638Diffuse Adenomatosis and Hepatocellular Carcinoma Treated with Liver Transplantation in an Adolescent Female with Kabuki Syndrome with a Novel KMT2D Gene Mutation
Q49589002Distinction of intrahepatic metastasis from multicentric carcinogenesis in multifocal hepatocellular carcinoma using molecular alterations.
Q47554590Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing.
Q60950078Dynamics of Axl Receptor Shedding in Hepatocellular Carcinoma and Its Implication for Theranostics
Q47108372Dysregulation of NRF2 in Cancer: from Molecular Mechanisms to Therapeutic Opportunities.
Q60920505Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance
Q28086796Dysregulation of ubiquitin ligases in cancer
Q38997020Emergence of the Noncoding Cancer Genome: A Target of Genetic and Epigenetic Alterations
Q34619389Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis.
Q26849263Epigenetics in liver disease
Q28079271Epigenetics in liver disease: from biology to therapeutics
Q36319724Epigenomic annotation of noncoding mutations identifies mutated pathways in primary liver cancer
Q64900609Establishment and genomic characterization of gingivobuccal carcinoma cell lines with smokeless tobacco associated genetic alterations and oncogenic PIK3CA mutation.
Q38214535Examining the impact of gene variants on histone lysine methylation
Q38182833Exploration of liver cancer genomes
Q37631655From Clinical Standards to Translating Next-Generation Sequencing Research into Patient Care Improvement for Hepatobiliary and Pancreatic Cancers
Q38614249Functional and genetic deconstruction of the cellular origin in liver cancer.
Q39067631Functions of bromodomain-containing proteins and their roles in homeostasis and cancer.
Q36863127Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.
Q28073241Genetic alterations in hepatocellular carcinoma: An update
Q64238165Genome-wide profiling of Epstein-Barr virus integration by targeted sequencing in Epstein-Barr virus associated malignancies
Q49884832Genomic Analysis Revealed New Oncogenic Signatures in TP53-Mutant Hepatocellular Carcinoma.
Q58612842Genomic Medicine and Implications for Hepatocellular Carcinoma Prevention and Therapy
Q42220401Genomic portrait of resectable hepatocellular carcinomas: implications of RB1 and FGF19 aberrations for patient stratification
Q47132620Genomic sequencing identifies a few mutations driving the independent origin of primary liver tumors in a chronic hepatitis murine model.
Q39404128Hepatocellular Malignant Neoplasm-NOS: A Clinicopathologic Study of 11 Cases from a Single Institution.
Q85238211Hepatocellular carcinoma
Q41682711High-throughput flow cytometry screening of human hepatocellular carcinoma reveals CD146 to be a novel marker of tumor-initiating cells
Q56976434Host and Viral Genetic Variation in HBV-Related Hepatocellular Carcinoma
Q36236839How do persistent infections with hepatitis C virus cause liver cancer?
Q34177518Identification and analysis of driver missense mutations using rotation forest with feature selection.
Q92316251Immunotherapy in Hepatocellular Carcinoma: Is There a Light at the End of the Tunnel?
Q90697982Implications of driver genes associated with a high tumor mutation burden identified using next-generation sequencing on immunotherapy in hepatocellular carcinoma
Q90270048Inflammatory Mechanisms of HCC Development
Q42248935KEAP the balance between life and death
Q99562760Ligation-Mediated Polymerase Chain Reaction Detection of 8-Oxo-7,8-Dihydro-2'-Deoxyguanosine and 5-Hydroxycytosine at the Codon 176 of the p53 Gene of Hepatitis C-Associated Hepatocellular Carcinoma Patients
Q38176242Liver cancer in 2013: Mutational landscape of HCC--the end of the beginning.
Q35913384Liver cancer oncogenomics: opportunities and dilemmas for clinical applications
Q46847748Local hypothyroidism favors the progression of preneoplastic lesions to hepatocellular carcinoma in rats
Q38686790Locoregional and systemic therapy for hepatocellular carcinoma
Q47393672Long Noncoding RNAs as a Key Player in Hepatocellular Carcinoma
Q56951623Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography
Q64977889Mechanisms of hepatocarcinogenesis in chronic hepatitis C.
Q38770560Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib.
Q34675280MicroRNAs in liver cancer: a model for investigating pathogenesis and novel therapeutic approaches.
Q41544729Molecular Pathogenesis of Hepatocellular Carcinoma.
Q26745338Molecular pathogenesis of hepatocellular carcinoma and impact of therapeutic advances
Q26766689Molecularly targeted therapy for advanced hepatocellular carcinoma - a drug development crisis?
Q26998606Multidisciplinary perspective of hepatocellular carcinoma: A Pacific Northwest experience
Q91637401Multimodal Meta-Analysis of 1,494 Hepatocellular Carcinoma Samples Reveals Significant Impact of Consensus Driver Genes on Phenotypes
Q54300991Mutational landscape of intrahepatic cholangiocarcinoma.
Q33618512Mutations acquired by hepatocellular carcinoma recurrence give rise to an aggressive phenotype
Q87416815New advances in precision medicine for hepatocellular carcinoma recurrence prediction and treatment
Q54170203Nrf2, but not β-catenin, mutation represents an early event in rat hepatocarcinogenesis.
Q92859614Phenotype-Based Screens with Conformation-Specific Inhibitors Reveal p38 Gamma and Delta as Targets for HCC Polypharmacology
Q64056540Potential Applications of NRF2 Inhibitors in Cancer Therapy
Q41547474Precision medicine for hepatocellular carcinoma: driver mutations and targeted therapy
Q47550861Primary Liver Cancers, Part 2: Progression Pathways and Carcinogenesis.
Q34734133Profiling of exome mutations associated with progression of HBV-related hepatocellular carcinoma.
Q58101915Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next Generation Sequencing for Matching Patients to Targeted and Immune Therapies
Q35147588Reciprocal interaction of Wnt and RXR-α pathways in hepatocyte development and hepatocellular carcinoma
Q33820159Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors
Q93016086Regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways in liver tumors: a review
Q56972496Roles of p53 in extrinsic factor-induced liver carcinogenesis
Q35919725Significance of genetic variants in DLC1 and their association with hepatocellular carcinoma
Q91657327Somatic mutation signatures in primary liver tumors of workers exposed to ionizing radiation
Q90911608Somatic mutations and clonal dynamics in healthy and cirrhotic human liver
Q37031712Sorafenib in advanced hepatocellular carcinoma: current status and future perspectives
Q26746255T3/TRs axis in hepatocellular carcinoma: new concepts for an old pair
Q37722129TP53 and RET may serve as biomarkers of prognostic evaluation and targeted therapy in hepatocellular carcinoma
Q92740295TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway
Q37408915Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma
Q36356419Targeted DNA and RNA sequencing of fine-needle biopsy FFPE specimens in patients with unresectable hepatocellular carcinoma treated with sorafenib
Q92504694Targeted genomic profiling identifies frequent deleterious mutations in FAT4 and TP53 genes in HBV-associated hepatocellular carcinoma
Q38923977Targeting multiple oncogenic pathways for the treatment of hepatocellular carcinoma
Q26830194Targeting the mTOR pathway in hepatocellular carcinoma: current state and future trends
Q53232555Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis.
Q57067866Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?
Q37336099The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers
Q89454724The critical role of glucose deprivation in epithelial-mesenchymal transition in hepatocellular carcinoma under hypoxia
Q98891422The genomic landscape of Mongolian hepatocellular carcinoma
Q34458870The genomic landscape of fibrolamellar hepatocellular carcinoma: whole genome sequencing of ten patients.
Q37720697The importance of a multidisciplinary approach to hepatocellular carcinoma
Q26777478The mutational landscape of hepatocellular carcinoma
Q41191439Therapeutic strategies for hepatocellular carcinoma: new advances and challenges
Q99352179Therapy of Primary Liver Cancer
Q40493822Transcriptome sequencing identified hub genes for hepatocellular carcinoma by weighted-gene co-expression analysis.
Q46609299Ubiquitin ligases in oncogenic transformation and cancer therapy
Q40046596Viral hepatitis and liver cancer.
Q98946922Whole-exome mutational landscape of metastasis in patient-derived hepatocellular carcinoma cells
Q35169245p53 requires the stress sensor USF1 to direct appropriate cell fate decision.
Q28392820p62 links autophagy and Nrf2 signaling
Q38893853p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer

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