Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth.

scientific article published on 09 June 2009

Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/1078-0432.CCR-08-2837
P932PMC publication ID2731998
P698PubMed publication ID19509165
P5875ResearchGate publication ID26278741

P50authorMichael SimonsQ39375925
P2093author name stringDebabrata Mukhopadhyay
Yasuhiro Ikeda
Adnan Memic
Ling Wang
Gustavo B Baretton
D Gomika Udugamasooriya
Chamila N Rupasinghe
Mark R Spaller
Daniela E Aust
Enfeng Wang
Kaustubh Datta
Michael H Muders
Pawan K Vohra
Shamit K Dutta
Silke Langer
P2860cites workGIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIPQ22003946
PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (tyrosinase-related protein-1)Q24291415
A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95Q24304455
GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathwaysQ24633321
Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.Q27331901
Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migrationQ28141795
A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemFQ28143494
Myosin VI: two distinct roles in endocytosisQ28191412
GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activationQ28201893
The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunitsQ28202295
GIPC Binds to the Human Lutropin Receptor (hLHR) through an Unusual PDZ Domain Binding Motif, and It Regulates the Sorting of the Internalized Human Choriogonadotropin and the Density of Cell Surface hLHRQ28204866
A PDZ domain protein interacts with the C-terminal tail of the insulin-like growth factor-1 receptor but not with the insulin receptorQ28205584
PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6BQ28209987
Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumorsQ28214970
5T4 interacts with TIP-2/GIPC, a PDZ protein, with implications for metastasisQ28215877
GIPC gene family (Review)Q28217646
Interactions of GIPC with Dopamine D2, D3but not D4Receptors Define a Novel Mode of Regulation of G Protein-coupled ReceptorsQ28573869
Role of ubiquitination in IGF-1 receptor signaling and degradationQ33280993
A human monoclonal autoantibody to breast cancer identifies the PDZ domain containing protein GIPC1 as a novel breast cancer-associated antigenQ33362597
Pancreatic cancer biology and geneticsQ35013204
GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signalingQ35131603
Act globally, think locally: systems biology addresses the PDZ domainQ36681194
Neuropilin-1-VEGFR-2 complexing requires the PDZ-binding domain of neuropilin-1.Q36869441
GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling.Q37594994
Expression and regulatory role of GAIP-interacting protein GIPC in pancreatic adenocarcinomaQ40213160
The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate developmentQ46230141
C terminus of RGS-GAIP-interacting protein conveys neuropilin-1-mediated signaling during angiogenesisQ47073889
GIPC Participates in G Protein Signaling Downstream of Insulin-like Growth Factor 1 ReceptorQ48872894
Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development.Q52009666
Targeting PDZ domain proteins for treating NMDA receptor-mediated excitotoxicityQ52571016
Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancerQ73181692
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectpancreatic cancerQ212961
P304page(s)4095-4103
P577publication date2009-06-09
P1433published inClinical Cancer ResearchQ332253
P1476titleTargeting GIPC/synectin in pancreatic cancer inhibits tumor growth
P478volume15

Reverse relations

cites work (P2860)
Q30353037Accidental interaction between PDZ domains and diclofenac revealed by NMR-assisted virtual screening.
Q50055562Association of cytosolic sialidase Neu2 with plasma membrane enhances Fas-mediated apoptosis by impairing PI3K-Akt/mTOR-mediated pathway in pancreatic cancer cells
Q35903324Chemically Modified Peptides Targeting the PDZ Domain of GIPC as a Therapeutic Approach for Cancer
Q28484039Clinical and functional characterization of a patient carrying a compound heterozygous pericentrin mutation and a heterozygous IGF1 receptor mutation
Q30452637Functional proteomics, human genetics and cancer biology of GIPC family members
Q28542464GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways
Q37461421GAIP-Interacting Protein, C-Terminus Is Involved in the Induction of Zinc-Finger Protein 143 in Response to Insulin-like Growth Factor-1 in Colon Cancer Cells
Q34218811Identification of a new class of MDM2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice
Q39249070Impact of the adaptor protein GIPC1/Synectin on radioresistance and survival after irradiation of prostate cancer
Q38965801Inhibition of endoglin-GIPC interaction inhibits pancreatic cancer cell growth
Q33705280Integrin α6A splice variant regulates proliferation and the Wnt/β-catenin pathway in human colorectal cancer cells
Q39571518Knockdown of ovarian cancer amplification target ADRM1 leads to downregulation of GIPC1 and upregulation of RECK.
Q38459674Minireview: Role of intracellular scaffolding proteins in the regulation of endocrine G protein-coupled receptor signaling
Q34439128Molecular characterization and ligand binding specificity of the PDZ domain-containing protein GIPC3 from Schistosoma japonicum
Q42048668Neuropilin-1 (NRP-1)/GIPC1 pathway mediates glioma progression
Q44110819Neuropilin-2 and its ligand VEGF-C predict treatment response after transurethral resection and radiochemotherapy in bladder cancer patients
Q37939947PDZ domains: the building blocks regulating tumorigenesis
Q37362694RGS-GAIP-interacting protein controls breast cancer progression
Q90999542Silencing of Neuropilins and GIPC1 in pancreatic ductal adenocarcinoma exerts multiple cellular and molecular antitumor effects
Q40899893The GIPC1-Akt1 Pathway Is Required for the Specification of the Eye Field in Mouse Embryonic Stem Cells
Q30994062Therapeutic implications of GIPC1 silencing in cancer
Q36090874VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells

Search more.